Network Pharmacology of Ayurvedic Multicomponent Formulation Diabecon Containing Gymnema sylvestre, Pterocarpus marsupium and Asphaltum punjabinum with Special Reference to Antidiabetic Property

Abstract

Network pharmacology, a burgeoning field amalgamating systems biology and computational biology, offers a promising avenue to unravel the intricate mechanisms of multi-component formulations in traditional medicine systems such as Ayurveda. This paper delves into the network pharmacology analysis of Diabecon, an Ayurvedic formulation comprising Gymnema sylvestre, Pterocarpus marsupium, and Asphaltum punjabinum, with a focus on its antidiabetic properties. Leveraging information from diverse databases and employing tools like Cytoscape, we constructed pharmacological networks elucidating the interactions between bioactive and molecular targets, particularly in the context of diabetes. Our analysis unveils novel insights into the synergistic effects of the constituents of Diabecon, shedding light on their mechanisms of action and potential therapeutic applications in managing diabetes mellitus. This research not only enhances our understanding of the pharmacodynamics of Diabecon but also paves the way for the identification of new therapeutic leads and targets for combating diabetes and related metabolic disorders.