2005
DOI: 10.1016/j.tins.2005.09.002
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Network reset: a simplified overarching theory of locus coeruleus noradrenaline function

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Cited by 724 publications
(752 citation statements)
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“…This suggests that LC or neighboring a 1 -receptors may also be involved in nonreward related motor functions or motor coordination. This is in agreement with recent findings that LC neuronal activity is highly correlated with operant response execution in positively motivated tasks (Clayton et al, 2004;Bouret and Sara, 2005). The behavioral activation found in previous studies after stimulation of LC a 1 -receptors may therefore be due to a combination of both motivational and motor effects.…”
Section: Discussionsupporting
confidence: 93%
“…This suggests that LC or neighboring a 1 -receptors may also be involved in nonreward related motor functions or motor coordination. This is in agreement with recent findings that LC neuronal activity is highly correlated with operant response execution in positively motivated tasks (Clayton et al, 2004;Bouret and Sara, 2005). The behavioral activation found in previous studies after stimulation of LC a 1 -receptors may therefore be due to a combination of both motivational and motor effects.…”
Section: Discussionsupporting
confidence: 93%
“…We believe that participants' identification of event boundaries corresponds to the resetting of event models when they perform event segmentation tasks. This account is consistent with a recent theory of locus ceruleus norepinephrine function, which proposes that norepinephrine serves as a general reset signal, allowing neural networks to move out of one stable state and settle into a new stable state based on the current network input (Bouret & Sara, 2005). We hypothesize that this reset is approximately hierarchically structured, such that resets of representations with longer timescales are generally a subset of resets of representations with shorter timescales.…”
Section: Perceptual Prediction and Error Detectionsupporting
confidence: 89%
“…This account is consonant with Bouret and Sara's (2005) view of NE as a neural interrupt signal that promotes learning (see also Bouret & Sara, 2004;David Johnson, 2003): "… these [LC] neurons are activated within behavioral contexts that require a cognitive shift -that is, interruption of ongoing behavior and adaptation. This LC activation occurs whenever there is a change in environmental imperative, such as the appearance of a novel, unexpected event, or a change in stimulus-reinforcement contingencies within a formal learning situation.…”
Section: ) the Relationship Between The P3 And Learningmentioning
confidence: 56%
“…Since the publication of the LC-P3 theory (Nieuwenhuis et al, 2005), researchers have advanced several new accounts that build on the role of phasic LC responses in learning (Bouret & Sara, 2005;Dayan & Yu, 2006;Verguts & Notebaert, 2009). These accounts may enhance our understanding of the P3 literature.…”
Section: ) the Relationship Between The P3 And Learningmentioning
confidence: 99%