Network Subgraph-based Method: Alignment-free Technique for Molecular Network Analysis
Efendi Zaenudin,
Ezra B. Wijaya,
Venugopal Reddy Mekala
et al.
Abstract:Objective:
We propose a novel method to compare directed networks by decomposing the network
into small modules, the so-called network subgraph approach, which is distinct from the network
motif approach because it does not depend on null model assumptions.
Method:
We developed an alignment-free algorithm called the Subgraph Identification Algorithm
(SIA), which could generate all subgraphs that have five connected nodes (5-node subgraph). There
were 9,364 such modules. Then, we applied the SIA method to exa… Show more
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