Networks regulating ubiquitin and ubiquitin-like proteins promise new therapeutic targets

Marsh, Deborah J.

doi:10.1530/erc-14-0585

Cited by 2 publications

(2 citation statements)

References 14 publications

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“…The attachment of UBLs to substrates affects enzymatic activity, subcellular localization or regulates protein interactions (Herrmann et al, 2007;van der Veen & Ploegh, 2012). As a consequence, UBLs generate extensive interest as therapeutic targets (Marsh, 2015).…”

Section: The Ubiquitin-like Protein Nedd8mentioning

confidence: 99%

“…Misregulated neddylation and CSN activity are involved in neurodegenerative disorders, cardiac disease and cancer (Lee et al, 2011;Chen et al, 2012b;Kandala et al, 2014). Targeting neddylation has become a promising task for the treatment of these diseases (Marsh, 2015). Therefore, the finding of a compensatory function of DenA under conditions in which the CSN complex is not active might play an important role in future research, especially for studies that aim to downregulate CSN activity by therapeutic drugs.…”

Section: Dena Provides An Auxiliary Function To Support Deneddylation...mentioning

confidence: 99%

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Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development

Schinke¹

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Malfunctioning protein degradation in higher eukaryotes is associated with numerous diseases, including neurodegenerative disorders and cancer. Understanding regulation mechanisms of protein degradation is thus of particular importance. The ubiquitinproteasome system selectively degrades intracellular proteins. Cullin-RING ligases, activated by the ubiquitin-like protein Nedd8, recognize target proteins and mediate

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Section: The Ubiquitin-like Protein Nedd8mentioning

confidence: 99%

Section: Dena Provides An Auxiliary Function To Support Deneddylation...mentioning

confidence: 99%

Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development

Schinke¹

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Expression profiles and potential functions of long noncoding RNAs and mRNAs in autoimmune pulmonary alveolar proteinosis patients

Yang

Xiang

et al. 2021

Aging

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Autoimmune pulmonary alveolar proteinosis (APAP) is a rare lung disease that may be associated with surfactant overaccumulation. To assess the function of long noncoding RNAs (lncRNAs) in APAP, we performed microarray analyses to identify differentially expressed (DE) lncRNAs and mRNAs between peripheral blood samples from five APAP patients and five healthy volunteers. In total, 12459 DE lncRNAs and 9331 DE mRNAs were identified in APAP patient samples. A qRT-PCR validation of 20 DE lncRNAs and 20 mRNAs indicated that 12 DE lncRNAs may be involved in the pathogenesis of APAP. Coding and noncoding co-expression (CNC) and competing endogenous RNA (ceRNA) regulatory networks were constructed with these 12 DE lncRNAs. Gene Ontology analysis of the downregulated mRNAs and the CNC network revealed that “ubiquitin-like protein transferase activity” was suppressed in APAP patient samples. Kyoto Encyclopedia of Genes and Genomes analysis demonstrated that the “MAPK signaling pathway” was enriched in the ceRNA network. Gene Ontology analysis also indicated that mRNAs involved in many transmembrane ion transport processes were upregulated in APAP patients. The DE lncRNAs and mRNAs discovered in this study have elucidated the pathogenesis of APAP, and the CNC and ceRNA networks have provided novel insights for future functional research.

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Networks regulating ubiquitin and ubiquitin-like proteins promise new therapeutic targets

Cited by 2 publications

References 14 publications

Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development

Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development

Expression profiles and potential functions of long noncoding RNAs and mRNAs in autoimmune pulmonary alveolar proteinosis patients

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