Neue Erfahrungen bei der toxikologisch kontrollierten Therapie einer ungewöhnlich schweren Vergiftung mit Nitrostigmin (E 605 forte<sup>®</sup>)

Boelcke, G; Butigan, N; Davar, H; Wd, Erdmann; Jw, Gaaz; Nenner, M

doi:10.1055/s-0028-1108867

Cited by 20 publications

(1 citation statement)

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“…Theoretical considerations concerning this question are based on oxime pharmacokinetic data obtained in healthy volunteers (Thompson et al 1987;Farrar et al 1990;Willems and Belpaire 1991). Neither is it known which plasma concentration is needed, and for how long, to counteract the possible long persistence of the AChE inhibitor in the body (Boelcke et al 1970;De Potter et al 1978;Mahieu et al 1982;Willems and Belpaire 1991).…”

Section: Introductionmentioning

confidence: 96%

Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients

Willems

Langenberg²,

Verstraete³

et al. 1992

Arch Toxicol

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Using pharmacokinetic data from healthy human volunteers in a bicompartmental pharmacokinetic model, a repeated dose scheme for pralidoxime methylsulphate (Contrathion) was developed producing plasma levels remaining above the assumed "therapeutic concentration" of 4 mg.l-1. Using the same data, it was found that a concentration of 4 mg.l-1 could also be obtained by a loading dose of 4.42 mg.kg-1 followed by a maintenance dose of 2.14 mg.kg-1.h-1. In order to study the pharmacokinetic behaviour of pralidoxime in poisoned patients, this continuous infusion scheme was then applied in nine cases of organophosphorus poisoning (agents: ethyl parathion, ethyl and methyl parathion, dimethoate and bromophos), and the pralidoxime plasma levels were determined. The mean plasma levels obtained in the various patients varied between 2.12 and 9 mg.l-1. Pharmacokinetic data were calculated, giving a total body clearance of 0.57 +/- 0.27 l.kg-1.h-1 (mean +/- SD), an elimination half-life of 3.44 +/- 0.90 h, and a volume of distribution of 2.77 +/- 1.45 l.kg-1.

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Section: Introductionmentioning

confidence: 96%

Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients

Willems

Langenberg²,

Verstraete³

et al. 1992

Arch Toxicol

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Parathion [Biomonitoring Methods in German language, 1978]

Eben¹

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Analytische Methoden zur Prüfung gesundheitsschädlicher Arbeitsstoffe: Analysen in biologischem Material , 3. Lieferung, Ausgabe 1978 Der Artikel enthält folgende Kapitel: 1. Zusammenfassung 2. Geräte, Chemikalien und Lösungen 2.1. Geräte 2.2. Chemikalien 2.3. Vergleichsstandards 3. Probenahme und Probenaufbereitung 4. Gaschromatographische Arbeitsbedingungen 5. Analytische Bestimmung 6. Eichkurve 7. Berechnung des Analysenergebnisses 8. Beurteilung des Verfahrens 8.1. Präzision 8.2. Richtigkeit 8.3. Nachweisgrenze 8.4. Störeinflüsse 9. Diskussion der Methode 10. Parathion

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Forensische Toxikologie

Mallinckrodt¹

1975

Gerichtliche Medizin

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Neue Erfahrungen bei der toxikologisch kontrollierten Therapie einer ungewöhnlich schweren Vergiftung mit Nitrostigmin (E 605 forte^®)

Cited by 20 publications

References 0 publications

Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients

Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients

Parathion [Biomonitoring Methods in German language, 1978]

Forensische Toxikologie

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Neue Erfahrungen bei der toxikologisch kontrollierten Therapie einer ungewöhnlich schweren Vergiftung mit Nitrostigmin (E 605 forte®)

Cited by 20 publications

References 0 publications

Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients

Plasma concentrations of pralidoxime methylsulphate in organophosphorus poisoned patients

Parathion [Biomonitoring Methods in German language, 1978]

Forensische Toxikologie

Contact Info

Product

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About

Neue Erfahrungen bei der toxikologisch kontrollierten Therapie einer ungewöhnlich schweren Vergiftung mit Nitrostigmin (E 605 forte^®)