Neue Fälle der Pelgerschen familiären Kernanomalie der Leukozyten¹

Abstract

Infolge eines günstigen Zusammentreffens liefen bei Verfasser in letzter Zeit von den verschiedensten Seiten Präparate zusammen, die einer der merkwürdigsten Entdeckungen auf dem Gebiete der Blutlehre, einer konstitutionellen Kernanomalie der Leukozyten, Bestätigung, Erweiterung und neue Gesichtspunkte zubrachten. Es handelt sich um die, von dem holländischen Hämatologen Dr. P,nem, Amsterdam, entdeckte eigenartige Form schwerer Kernverschiebung der 1 Demonstration im Verein für Innere Medizin am 9. I. 1933.

The Pelger‐huet Anomaly of the Leucocytes

“…In 1931 he reported a second case, and Huet (1931) found similar cells in a niece of one of Pelger's patients which led to the examination of the remaining relatives and the finding of other affected members, whom Huet reported with two more families from Holland in 1932. In the same year the publications of Burger and J ordans appeared, and in 1933 Undritz described a family from Switzerland with what he then called the pseudo-regenerative white blood cell picture, and Schilling (1933) fully investigated two new families, one from Czechoslovakia and one from Germany (Weigeldt, 1933) . It was Schilling who first suggested that the unusual change in the white cells be termed the Pelger-Huet anomaly of the leucocytes.…”

“…The blood groups are not given. Schilling (1933) was the first to point out the possible medico-legal importance of the anomaly, and Undritz (1943) conjectured that as all the leucocytes are affected in this condition, the general body cells may be affected also, at least those which develop from the mesenchyme.…”