Neue WHO-Klassifikation der Hodentumoren 2022

Fichtner, Alexander; Ströbel, Philipp; Bremmer, Felix

doi:10.1007/s00292-022-01112-1

Cited by 3 publications

(2 citation statements)

References 38 publications

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“…The current diagnostic criteria for STSMs required by the 5th edition of the WHO classification of thoracic tumours is an overgrowth of sufficient size, occupying an area of at least a ×4 microscopic field 17 . However, for the sake of uniformity, we recommend using as a criterion at least 5 mm in diameter for the diagnosis of STSMs, because this was proposed by the 5th edition of the WHO classification of tumours of the urinary tract and male genital organs as the diagnostic criteria of STSMs 126 . Furthermore, the pathological report should include the percentage of STSMs in a PMGCT because of its prognostic significance 24 …”

Section: Pmgcts With Somatic‐type Solid Malignanciesmentioning

confidence: 99%

“…17 However, for the sake of uniformity, we recommend using as a criterion at least 5 mm in diameter for the diagnosis of STSMs, because this was proposed by the 5th edition of the WHO classification of tumours of the urinary tract and male genital organs as the diagnostic criteria of STSMs. 126 Furthermore, the pathological report should include the percentage of STSMs in a PMGCT because of its prognostic significance. 24 The most frequent STSMs are sarcomas, especially rhabdomyosarcomas (60%) and angiosarcomas, 24,127 but also leiomyosarcomas, malignant peripheral nerve sheath tumours and primitive neuroectodermal tumours (PNETs) can be seen.…”

Section: Pmgcts With Somatic-type Solid Malignanciesmentioning

confidence: 99%

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Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Fichtner,

Marx,

Ströbel

et al. 2023

Histopathology

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This article will review current aspects of the histopathological, immunohistochemical and molecular analysis of primary mediastinal germ cell tumours (PMGCTs) as well as their aetiological, epidemiological, clinical and therapeutic features. PMGCTs represent an important differential diagnosis in the spectrum of mediastinal tumours, and their diagnosis is usually made on small tissue samples from core needle biopsies in combination with diagnostic imaging and serum tumour markers. As in lymphomas, a small biopsy is often the only viable tumour sample available from these patients, as they receive chemotherapy prior to eventual surgical resection. Pathologists therefore need to apply an efficient combination of immunohistochemical markers to confirm the diagnosis of a PMGCT and to exclude morphological mimics.

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Section: Pmgcts With Somatic‐type Solid Malignanciesmentioning

confidence: 99%

Section: Pmgcts With Somatic-type Solid Malignanciesmentioning

confidence: 99%

Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Fichtner,

Marx,

Ströbel

et al. 2023

Histopathology

Self Cite

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Fundamentals in the pathology of testicular tumours

Fichtner,

Bremmer

2024

Pathologie

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Gonadal Teratomas: A State-of-the-Art Review in Pathology

Salzillo,

Imparato,

Fortarezza

et al. 2024

Cancers

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Teratomas are neoplasms arising from germ cells and encompass tissues derived from two or more embryonic germ layers, including ectoderm, mesoderm, and endoderm. These tumours typically localize along the midline or in paramedian positions and can manifest as gonadal (20%) or extragonadal (80%) entities. Although gonadal teratomas are uncommon, they represent the predominant type of gonadal tumour in the paediatric population. They comprise approximately 20–25% of all ovarian tumours in females and about 3–5% of all testicular tumours in males. Ovarian teratomas exhibit a higher incidence in early childhood and adolescence, whereas testicular teratomas are more prevalent during the first three months of life and between the ages of 15 and 19. While the majority of paediatric gonadal teratomas are benign, malignant or mixed variants may also arise, necessitating more aggressive therapeutic interventions.

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Neue WHO-Klassifikation der Hodentumoren 2022

Cited by 3 publications

References 38 publications

Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Primary germ cell tumours of the mediastinum: A review with emphasis on diagnostic challenges

Fundamentals in the pathology of testicular tumours

Gonadal Teratomas: A State-of-the-Art Review in Pathology

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