Neues zur Therapie der okulären Tuberkulose

Brönnimann, Larissa Christina; Zimmerli, Stefan; Garweg, Justus G.

doi:10.1007/s00347-020-01099-1

Cited by 2 publications

(7 citation statements)

References 50 publications

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“…The suspected diagnosis can often be made only based on the course of the disease and response to therapy. 2,5 In the patient presented here, infection with M. bovis was demonstrated by lymph node biopsy. No pathogen detection beyond Mycobacterium tuberculosis complex has been described in the few sufoveal tuberculomas described to date.…”

Section: Discussionmentioning

confidence: 78%

“…Ocular TB often occurs without the involvement of the lungs as an extrapulmonary form or in the context of latent TB. 2,4,5 It is a rare condition in Europe and North America, accounting for approximately 0.2% of infectious uveitis cases, whereas it is much more common in high-risk countries, such as India, where it accounts for up to 10.5% of infectious uveitis cases. 6 Theoretically, the pathogen can penetrate through surface tissue, that is, conjunctiva, cornea, or sclera, causing primary ocular TB.…”

Section: Discussionmentioning

confidence: 99%

“…1,2 A combination with steroids or immunosuppressants is recommended to limit inflammation-related damage but should never be given without ATT. 2,7 Therapy for M. bovis is the same as for M. tuberculosis, except that M. bovis has a universal resistance to PZA and hence is not recommended for M. bovis because of increased rates of treatment failure. Therefore, differentiation between M. bovis and other species is important.…”

Section: Discussionmentioning

confidence: 99%

“…1 Mycobacteria need oxygen-rich blood and good circulation, which explains the predilection of the uvea. 2 Another well-documented form of appearance is choroidal tubercles. They appear as multiple yellowish to greyish white nodules ranging in size from 0.5 to 3.0 mm, typically in the central choroid, which may be surrounded by edema, exudates, or hemorrhages.…”

Section: Discussionmentioning

confidence: 99%

“…Most patients with ocular manifestations of TB have no history of pulmonary or systemic TB. 1,2 There are three species of mycobacteria capable of causing TB, of which Mycobacterium bovis makes up only a small percentage depending on the geographic localization. In industrialized countries like the United States, TB infections caused by M. bovis have been nearly eradicated because of the pasteurization of milk and now account for only 1% to -2% of all TB infections.…”

mentioning

confidence: 99%

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Subfoveal choroidal tuberculoma in a healthy young woman caused by Mycobacterium bovis.

Schopp

Strzałkowski

Dithmar

2022

RETINAL Cases &Amp; Brief Reports

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Purpose: To describe a case of a macular tuberculoma in a young and healthy woman after developing a tuberculous lymphadenitis caused by Mycobacterium bovis.Methods: Retrospective case report.Results: Tuberculous lymphadenitis caused by M. bovis was detected after biopsy and histological examination as well as polymerase chain reaction test testing of cervical lymph nodes in a 20-year-old patient. An interferon gamma was positive. Shortly starting antitubercular therapy, the patient developed visual deterioration caused by a single yellowish subretinal structure in the macula of the right eye. Optical coherence tomography showed a dome-shaped, hyperreflective, subfoveal choroidal lesion with subtle subretinal fluid. Antitubercular therapy with isoniazid, rifampicin, ethambutol, and pyrazinamide was performed, and the deescalation therapy with isoniazid and rifampicin was extended to 7 months. Further examinations showed regression of choroidal tuberculoma to a scar.Conclusion: This is the first reported case of choroidal tuberculoma after tuberculous lymphadenitis caused by M. bovis.

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Section: Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Subfoveal choroidal tuberculoma in a healthy young woman caused by Mycobacterium bovis.

Schopp

Strzałkowski

Dithmar

2022

RETINAL Cases &Amp; Brief Reports

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Sustained Delivery of Rifampicin Nanoformulation Administration Intravitreally Into Rabbit Eyes for Ocular Tuberculosis

Yadav,

Tiwari,

Kumar

et al. 2024

Cureus

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Introduction: Diagnosis and treatment of ocular tuberculosis is very challenging. It poses a significant and potential management dilemma after diagnosis as a primary, active, or secondary infection. The higher amounts of orally administered antitubercular drugs are needed to achieve the therapeutic concentration in the eye, which may lead to a higher risk of side effects. However, the intravitreal administration of drugs is not practiced because of the frequent administration of the injections.Methods: This study was carried out to develop, optimize, and characterize rifampicin-loaded poly (lacticco-glycolic acid) (PLGA) nanoparticles to make them sustained release followed by the direct administration of plain rifampicin and rifampicin nano-formulations in the vitreous of rabbit eyes. Both groups were comparatively assessed for the sustained delivery of the two preparations in the vitreous and their systemic toxicity.Results: The characteristics of rifampicin-loaded nanoparticles were 786 nm in size with narrow size distribution along with a zeta potential of -12 mV. The drug encapsulation efficiency and loading capacity were 67.68% w/w and 42.28% w/w, respectively. The four New Zealand white rabbits were divided into two groups and given plain rifampicin (50µl volume) and PLGA nanoformulations of rifampicin (50µl volume) in each eye. In vivo, rifampicin-loaded PLGA nanoparticles produced sustained release of rifampicin for a week, even obtaining the 0.51 µg/ml levels on the seventh day in vitreous against negligible levels after one day for free rifampicin. The Cmax levels for free Rifampicin and Rifampicin nanoparticles were 0.44 µg/ml and 1.86 µg/ml, respectively. Conclusion: In this experimental proof-of-concept study, we have found that rifampicin-loaded PLGA nanoparticles released rifampicin in a sustained manner for up to seven days compared to free drugs only for one day into the vitreous. The intravitreal-administered drug did not reach systemic circulation.

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Neues zur Therapie der okulären Tuberkulose

Cited by 2 publications

References 50 publications

Subfoveal choroidal tuberculoma in a healthy young woman caused by Mycobacterium bovis.

Subfoveal choroidal tuberculoma in a healthy young woman caused by Mycobacterium bovis.

Sustained Delivery of Rifampicin Nanoformulation Administration Intravitreally Into Rabbit Eyes for Ocular Tuberculosis

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