Neumonía bacterémica por Neisseria meningitidis: Primer caso reportado en Chile y revisión bibliográfica

Yubini, María Cecilia; Contreras, Caterina; Díaz, Gonzalo A.; Cerdá, María; Guiñez, Dannette; Rogers, Nicole H.; Silva, Francisco; Cornejo, Rodrigo

doi:10.4067/s0034-98872018000200249

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…A myriad of case reports of patients of all ages with meningococcal pneumonia has been published over the years from various regions of the world, including the US [4, 20, 42, 84–88], Europe [24, 89–97], the United Kingdom [98, 99], Russia [100], Japan [101–103], Taiwan [104], Australia [105], South America [106, 107] and Oman [69]. The characteristics of the patients with meningococcal pneumonia were similar to those described elsewhere in this review.…”

Section: Introductionmentioning

confidence: 99%

Meningococcal pneumonia: a review

Feldman

Anderson

2019

Pneumonia

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Background Although Neisseria meningitidis is one of the major causes of meningitis, meningococcal pneumonia is the most common non-neurological organ disease caused by this pathogen. Methods We conducted a review of the literature to describe the risk factors, pathogenesis, clinical features, diagnosis, treatment and prevention of meningococcal pneumonia. Results Meningococcal pneumonia was first described in 1907 and during the 1918–1919 influenza pandemic large numbers of cases of meningococcal pneumonia occurred in patients following the initial viral infection. A number of publications, mainly case series or case reports, has subsequently appeared in the literature. Meningococcal pneumonia occurs mainly with serogroups Y, W-135 and B. Risk factors for meningococcal pneumonia have not been well characterised, but appear to include older age, smoking, people living in close contact (e.g. military recruits and students at university), preceding viral and bacterial infections, haematological malignancies, chronic respiratory conditions and various other non-communicable and primary and secondary immunodeficiency diseases. Primary meningococcal pneumonia occurs in 5–10% of patients with meningococcal infection and is indistinguishable clinically from pneumonia caused by other common pathogens. Fever, chills and pleuritic chest pain are the most common symptoms, occurring in > 50% of cases. Productive sputum and dyspnoea are less common. Diagnosis of meningococcal pneumonia may be made by the isolation of the organism in sputum, blood, or normally sterile site cultures, but is likely to underestimate the frequency of meningococcal pneumonia. If validated, PCR-based techniques may be of value for diagnosis in the future. While penicillin was the treatment of choice for meningococcal infection, including pneumonia, prior to 1991, a third generation cephalosporin has been more commonly used thereafter, because of concerns of penicillin resistance. Chemoprophylaxis, using one of a number of antibiotics, has been recommended for close contacts of patients with meningococcal meningitis, and similar benefits may be seen in contacts of patients with meningococcal pneumonia. Effective vaccines are available for the prevention of infection with certain meningococcal serogroups, but this field is still evolving. Conclusion Meningococcal pneumonia occurs fairly frequently and should be considered as a possible cause of pneumonia, particularly in patients with specific risk factors.

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Section: Introductionmentioning

confidence: 99%

Meningococcal pneumonia: a review

Feldman

Anderson

2019

Pneumonia

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Principais microrganismos associados as infecções respiratórias e seus agravos a saúde: uma revisão da literatura

Santana

Sousa

Nunes

et al. 2020

RSD

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Objetivo: Descrever os principais microrganismos associados as infecções respiratórias, listando assim, bactérias, vírus, fungos, protozoários e helmintos. Metodologia: Trata-se de uma revisão de literatura do tipo descritiva com abordagem qualitativa, cuja seleção de materiais foi realizada por meio de critérios pré estabelecidos, os quais, corroboraram para a especificidade da busca nas bases de dasos: SciELO, PubMed e o portal de periódicos da CAPES, sendo inclusos, um total de 42 conteúdos, estes, publicados entre os anos de 2010 a 2020. Resultados e Discussão: Vários são os microrganismos responsáveis pelo acometimento de infecções no trato respiratório, tendo as bactérias como os principais agentes infecciosos neste sentido, sendo adquiridas na comunidade, mas com ênfase para sua contaminação, no ambiente hospitalar. Os vírus, por sua vez, se correlacionam com o potencial de morbidade e mortalidade nas doenças por eles causadas. Além desses microrganismos, os fungos, protozoários e helmintos também possuem a capacidade de promover infecções pulmonares. Conclusão: Em suma, pode-se afirmar a grande variedade de microrganismos envolvidos no acometimento de infecções respiratórias. Frente a essencialidade fisiológica dos pulmões, e o comprometimento que as infecções resultam, muita das vezes de forma irrversiveis ou deixando sequelas, gera-se a necessidade de estudos destinados a elaboração de terapêuticas para a estabilização dos pacientes comprometidos.

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The Epidemiology of Meningococcal Disease and Carriage, Genotypic Characteristics and Antibiotic Resistance of Neisseria meningitidis Isolates in Zhejiang Province, China, 2011–2021

et al. 2022

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Neisseria meningitidis (Nm) remains a worldwide leading cause of epidemic meningitis. During 2011–July 2021, 55 meningococcal disease (MD) cases were reported with a case fatality rate of 5.45% in Zhejiang Province, China. The median age was 7 years. The annual incidence was 0.0017–0.0183 per 100,000 population. The highest age-specific incidence was observed in the group younger than 1 year. Serogroup was identified in 30 laboratory-confirmed MD cases, and MenB was most predominant. MenB was mainly observed in two age groups: younger than 5 and older than 35 years. MenB incidence was significantly increasing from 0.0018 per 100,000 in 2013 to 0.0070 per 100,000 in 2019. During 2015–2020, 17 positive samples were detected from 2,827 throat swabs from healthy population, of which 70.59% was MenB. Twenty multilocus sequence typing sequence types (STs) containing eight newly assigned STs (ST15881–ST15888) were determined in all Nm isolates. Either in MD cases or in healthy population, MenB CC ST-4821 was the predominant ST. It was worth noting that two MenY CC ST-23 cases occurred in 2019 and 2021, respectively. MenY CC ST-23 MD cases increased gradually in China. Phylogeny results based on genome sequencing indicated that Chinese MenW CC ST-11 isolates were genetically linked and grouped together with Japanese isolates, separated from MenW CC ST-11 isolates from Saudi Arabia Hajj outbreak, Europe, South Africa, South America, North America, and Oceania. MenW CC ST-11 isolates from East Asia might have evolved locally. Antibiotic susceptibility tests revealed a relatively high resistance rate (22.86%) of Nm isolates to penicillin. This study provided valuable data for Chinese public health authorities to grasp the temporal epidemiological characteristics of MD and healthy carriage.

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Neumonía bacterémica por Neisseria meningitidis: Primer caso reportado en Chile y revisión bibliográfica

Cited by 3 publications

References 10 publications

Meningococcal pneumonia: a review

Meningococcal pneumonia: a review

Principais microrganismos associados as infecções respiratórias e seus agravos a saúde: uma revisão da literatura

The Epidemiology of Meningococcal Disease and Carriage, Genotypic Characteristics and Antibiotic Resistance of Neisseria meningitidis Isolates in Zhejiang Province, China, 2011–2021

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