Neural activations during cognitive and affective theory of mind processing in healthy adults with a family history of alcohol use disorder

Abstract

Background Social cognition impairments are a common feature of alcohol use disorders (AUD). However, it remains unclear whether these impairments are solely the consequence of chronic alcohol consumption or whether they could be a marker of vulnerability. Methods The present study implemented a family history approach to address this question for a key process of social cognition: theory of mind (ToM). Thirty healthy adults with a family history of AUD (FH+) and 30 healthy adults with a negative family history of AUD (FH−), matched for age, sex, and education level, underwent an fMRI cartoon-vignette paradigm assessing cognitive and affective ToM. Participants also completed questionnaires evaluating anxiety, depressive symptoms, childhood trauma, and alexithymia. Results Results indicated that FH+ individuals differed from FH− individuals on affective but not cognitive ToM processing, at both the behavioral and neural levels. At the behavioral level, the FH+ group had lower response accuracy for affective ToM compared with the FH− group. At the neural level, the FH+ group had higher brain activations in the left insula and inferior frontal cortex during affective ToM processing. These activations remained significant when controlling for depressive symptoms, anxiety, and childhood trauma. Conclusions These findings highlight difficulties during affective ToM processing among first-degree relatives of AUD patients, supporting the idea that some of the impairments exhibited by these patients may already be present before the onset of AUD and may be considered a marker of vulnerability.

Patterns of executive functions and theory of mind in adults with a family history of alcohol use disorder: Combined group and single‐case analyses

“…Few studies have explored common SC components (i.e., emotion recognition, empathy, and ToM), and if so, they have only targeted affective SC components such as emotion recognition, emotion regulation or affective ToM (i.e., mental state decoding). ToM, a key component of SC, has been shown to be severely impaired in individuals with AUD (Bora & Zorlu, 2017), but only one prior fMRI study has investigated affective and cognitive ToM performances in FH+ individuals (Schmid et al, 2023). This study reported higher brain activation in the left insula and inferior frontal cortex in FH+ compared with FH− individuals.…”

“…an interest in affective and low-level SC processes while affective and higher order SC processes have remained largely unexplored. To fill this gap of the literature, our team recently conducted an fMRI study investigating both, affective and cognitive SC processes, in FH+ adults through a ToM task requiring high-level mental state reasoning (Schmid et al, 2023). The results highlighted differences in terms of neural activations between the FH+ and FH− groups during affective ToM processing in the left insula and inferior frontal cortex.…”