In the realm of large-scale systems, the complexity of controller design has long been exacerbated by the proliferation of decision variables and inherent conservatism. This study introduces a novel approach to address these challenges, presenting a new distributed robust controller design methodology tailored for large-scale systems grappling with disturbances, uncertainties, and actuator saturations. The primary objectives include reducing conservatism, minimizing decision variables, and significantly curtailing computation time. To surmount these hurdles, the research leverages descriptive and reciprocally convex methods, formulating the design procedure using linear matrix inequalities. This enables the adjustment of uncertain parameters and robust disturbance rejection, thereby ensuring stability in large-scale systems. Additionally, a feedback control law is proposed to accommodate saturation constraints and ensure the closed-loop system’s stability. Notably, the effectiveness of the proposed control scheme is demonstrated through the evaluation of a full-car active suspension system, which is partitioned into interconnected subsystems to a large-scale system. Comparative analyses underscore the superior performance and technical advancements offered by the proposed methodology over existing approaches.