Neural and Behavioral Plasticity Associated with the Transition from Controlled to Escalated Cocaine Use

Ferrario, Carrie R.; Gorny, Grazyna; Crombag, Hans S.; Li, Yilin; Kolb, Bryan; Robinson, Terry E.

doi:10.1016/j.biopsych.2005.04.046

Cited by 252 publications

(313 citation statements)

References 47 publications

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“…In all studies to date, both non-contingent and contingent cocaine or amphetamine administration were found to increase spine density, as well as dendritic branching on medium spiny GABAergic neurons within both the shell and core subregions of the NAC [198][199][200][201][202][203][204][205][206][207]. Similarly, repeated treatment with both psychomotor stimulants increase spine density and branching of the apical, and to a lesser extent the basalar, dendrites of glutamatergic pyramidal neurons within the PFC [198][199][200][201]204,205]. These structural data are consistent with greater levels of filamentous actin (Factin) within the NAC following both acute exposure to and withdrawal from repeated cocaine exposure [129].…”

Section: Potential Role For Homers In Drug-induced Alterations In Strmentioning

confidence: 98%

Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

160

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Drug addiction is a chronic, relapsing disorder, characterized by an uncontrollable motivation to seek and use drugs. Converging clinical and preclinical observations implicate pathologies within the corticolimbic glutamate system in the genetic predisposition to, and the development of, an addicted phenotype. Such observations pose cellular factors regulating glutamate transmission as likely molecular candidates in the etiology of addiction. Members of the Homer family of proteins regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. This review summarizes the existing data implicating the Homer family of protein in acute behavioral and neurochemical sensitivity to drugs of abuse, the development of drug-induced neuroplasticity, as well as other behavioral and cognitive pathologies associated with an addicted state.

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Section: Potential Role For Homers In Drug-induced Alterations In Strmentioning

confidence: 98%

Homers regulate drug-induced neuroplasticity: Implications for addiction

Szumlinski

Ary

Lominac

2008

Biochemical Pharmacology

118

160

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“…In addition, most studies using methamphetamine self-administration have employed relatively short daily access to the drug (1 or 2 h/day). Longer daily access (e.g., 6 h/day) to cocaine sometimes results in an escalation of drug intake (Ahmed et al 2002;Ferrario et al 2005;Vanderschuren and Everitt 2004) and can increase the magnitude of reinstatement produced by cues or drug priming injections (Kippin et al 2006). Of particular importance for methamphetamine is the possibility that extended daily drug access may produce cognitive deficits that are akin to those seen in human methamphetamine addicts who undergo repeated binge administration.…”

Section: Introductionmentioning

confidence: 99%

Extended methamphetamine self-administration enhances reinstatement of drug seeking and impairs novel object recognition in rats

2008

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Rationale-Methamphetamine is a highly addictive psychostimulant, and chronic methamphetamine users show high rates of relapse. Furthermore, prolonged methamphetamine abuse can lead to psychiatric symptoms and has been associated with various cognitive dysfunctions. However, the impact of self-administered methamphetamine on cognitive dysfunction and relapse has not been concurrently examined in an animal model.Objectives-The present study determined the effects of short-vs. long-access contingent methamphetamine on self-administration, extinction responding, reinstatement of methamphetamine seeking, and cognitive performance on an object exploration task.Materials and methods-Long-Evans rats self-administered methamphetamine i.v. (0.02 mg/ infusion) or received saline during daily sessions (1 or 2 h) for 10 days, followed by either maintained short-(1 or 2 h) or long-access (6 h) self-administration for 14 days. Lever responding was extinguished prior to reinstatement, which consisted of presentation of drug-paired cues or a priming injection of methamphetamine (1.0 mg/kg). Animals were also tested on an object exploration task prior to self-administration and at 10−12 days after cessation of self-administration, thus providing a comparison of pre-methamphetamine exposure with post-methamphetamine exposure.Results-Long-access methamphetamine self-administration resulted in escalation of daily intake. Furthermore, animals in both short-and long-access groups showed robust conditioned-cued and drug-primed reinstatement, with long access resulting in enhanced methamphetamine-primed reinstatement. Methamphetamine self-administration also led to access-dependent impairments on novel object recognition but failed to impair recognition of spatial reconfiguration.Conclusions-Extended methamphetamine self-administration enhances drug-primed reinstatement and decreases novel object recognition, indicating that prolonged contingent methamphetamine increases motivation for drug seeking following withdrawal while increasing cognitive deficits.

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“…However, there is little evidence to date of longlasting alterations of prefrontal cortex function in an animal model of loss of control over drug use. Despite accumulating evidence that limited drug exposure induces neuronal changes in the prefrontal cortex (Ben-Shahar et al, 2007;Bowers et al, 2004;Crespo et al, 2002), there is little evidence to date of long-lasting neuronal adaptations of the prefrontal cortex after escalation in cocaine intake with extended access (Ben-Shahar et al, 2007;Ferrario et al, 2005;Seiwell et al, 2007). Moreover, recent reports demonstrated that extended access to cocaine self-administration did not induce long-lasting impairment of prefrontal cortex cognitive function, such as response inhibition and sustained attention (Dalley et al, 2005(Dalley et al, , 2007.…”

Section: Introductionmentioning

confidence: 99%

Extended Access to Cocaine Self-Administration Produces Long-Lasting Prefrontal Cortex-Dependent Working Memory Impairments

George

Mandyam

Wee

et al. 2007

Neuropsychopharmacol

155

127

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Humans with drug addiction exhibit compulsive drug-seeking associated with impairment of prefrontal cortex cognitive function. Whether prefrontal cortex dysfunction is a consequence of chronic drug exposure, or mediates the transition from drug use to drug dependence, is unknown. The current study investigates whether a history of escalated vs controlled cocaine intake is associated with specific working memory impairments, and long-lasting alterations of the dorsomedial prefrontal cortex and orbitofrontal cortex in rats. Working memory was assessed in rats with a history of extended (6 h per session) or limited (1 h per session) access to cocaine (0.5 mg/kg per injection), 3-17 days after the last self-administration session, using a delayed nonmatching-to-sample task. The density of neurons, oligodendrocytes, and astrocytes was quantified in the dorsomedial prefrontal cortex and orbitofrontal prefrontal cortex 2 months after the last self-administration session. Working memory impairments were observed after a history of chronic and escalated cocaine intake, but not after repeated limited access to cocaine. Moreover, working memory impairments were correlated with a decreased density of neurons and oligodendrocytes but not astrocytes in the dorsomedial prefrontal cortex, and with a decreased density of oligodendrocytes in the orbitofrontal cortex. Considering the role of the prefrontal cortex in goal-directed behavior, the prefrontal cortex dysfunctions observed here may exacerbate the loss of control associated with increased drug use and facilitate the progression to drug addiction.

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Neural and Behavioral Plasticity Associated with the Transition from Controlled to Escalated Cocaine Use

Cited by 252 publications

References 47 publications

Homers regulate drug-induced neuroplasticity: Implications for addiction

Homers regulate drug-induced neuroplasticity: Implications for addiction

Extended methamphetamine self-administration enhances reinstatement of drug seeking and impairs novel object recognition in rats

Extended Access to Cocaine Self-Administration Produces Long-Lasting Prefrontal Cortex-Dependent Working Memory Impairments

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