Neural and clinical changes of cognitive behavioural therapy versus talking control in patients with major depression: a study protocol for a randomised clinical trial

Katayama, Nariko; Nakagawa, Atsuo; Kurata, Chika; Sasaki, Yohei; Mitsuda, Dai; Nakao, Shigetsugu; Mizuno, Sayuri; Ozawa, Mire; Nakagawa, Yuko; Ishikawa, Natsumi; Umeda, Satoshi; Terasawa, Yuri; Tabuchi, Hajime; Kikuchi, Toshiaki; Abe, Takayuki; Mimura, Masaru

doi:10.1136/bmjopen-2019-029735

Cited by 5 publications

(2 citation statements)

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“…The present study was a 16-week RCT of two parallel groups with a 12-month follow-up. The full RCT protocol has been published elsewhere ( 16 ). This study was registered with the UMIN Clinical Trials Registry (identifier: UMIN000018155) and approved by the Ethical Review Committee of Keio University School of Medicine (reference No.…”

Section: Methodsmentioning

confidence: 99%

The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial

et al. 2023

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BackgroundPessimistic thinking about the future is one of the cardinal symptoms of major depression. Few studies have assessed changes in pessimistic thinking after undergoing cognitive behavioral therapy (CBT). A randomized clinical trial (RCT) was conducted with patients diagnosed with major depressive disorder (MDD) to determine whether receiving a course of CBT affects pessimistic future thinking using a future thinking task.MethodsThirty-one patients with MDD were randomly assigned to either CBT (n = 16) or a talking control (TC) (n = 15) for a 16-week intervention. The main outcomes were the change in response time (RT) and the ratio of the responses for positive valence, measured by the future thinking task. Secondary outcomes included the GRID-Hamilton Depression Rating Scale, the Beck Depression Inventory-Second Edition (BDI-II), the Dysfunctional Attitude Scale (DAS), and the word fluency test (WFT).ResultsRegarding the main outcomes, the CBT group showed reduced RT for the positive valence (within-group Cohen’s d = 0.7, p = 0.012) and negative valence (within-group Cohen’s d = 0.6, p = 0.03) in the distant future condition. The ratio of positive valence responses in both groups for all temporal conditions except for the distant past condition increased within group (distant future: CBT: Cohen’s d = 0.5, p = 0.04; TC: Cohen’s d = 0.8, p = 0.008; near future: CBT: Cohen’s d = 1.0, p < 0.001; TC: Cohen’s d = 1.1, p = 0.001; near past: CBT: Cohen’s d = 0.8, p = 0.005; TC: Cohen’s d = 1.0, p = 0.002). As for secondary outcomes, the CBT group showed greater improvement than the TC group regarding the need for social approval as measured by the DAS (p = 0.012).ConclusionPatients with MDD who received CBT showed a reduced RT for the positive and negative valence in the distant future condition. RT in the future thinking task for depressed patients may be a potential objective measure for the CBT treatment process. Because the present RCT is positioned as a pilot RCT, a confirmatory trial with a larger number of patients is warranted to elucidate the CBT treatment process that influences future thinking.Clinical trial registrationhttps://center6.umin.ac.jp/cgi-open-bin/icdr_e/ctr_view.cgi?recptno=R000021028, identifier UMIN000018155.

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Section: Methodsmentioning

confidence: 99%

The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial

et al. 2023

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“…However, MDD more often requires other treatment measures, such as antidepressant treatment, electroconvulsive therapy [9], or cognitive behavioral therapy (CBT) [10]. Therefore, understanding the differences in the neural bases between MDD and SD could be important in early diagnosis and the choice of the appropriate treatment.…”

Section: Introductionmentioning

confidence: 99%

Is there any difference in the fractional amplitude of low-frequency fluctuations between first episode major depressive disorder patients and subclinical depressive subjects?

Xie¹,

Ruan²,

Zhang³

et al. 2020

Preprint

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Background To explore the differences in the fractional amplitude of low-frequency fluctuations (fALFF) at the whole-brain level between young adults with major depressive disorder (MDD) and those with Subclinical depression (SD). Methods Thirty-nine first-episode MDD patients, 30 SD subjects, and 37 healthy controls (HCs) were recruited. All participants underwent resting-state fMRI (Rs-fMRI) scans on a 3T MR scanner. We used the fALFF to explore spontaneous neuronal activity between groups. Results Significant differences in the fALFF were observed among the three groups. Compared with the HCs, an increased fALFF was found in the left cerebellum in MDD patients. When MDD patients were compared with SD subjects, we observed increased fALFF values in the bilateral fusiform gyrus and decreased fALFF values in the right inferior frontal gyrus, right superior frontal gyrus, right middle frontal gyrus, left cuneus and right precuneus. Compared with the HCs, the SD group demonstrated increased fALFF values in the precuneus. Additionally, a positive correlated was revealed between the fALFF values and Hamilton Anxiety Scale (HAMA)score in the right fusiform gyrus in MDD patients. Moreover, the fALFF value were negatively correlated with the Beck Depression Inventory (BDI) score in the right inferior frontal gyrus and with the age in the left fusiform gyrus in SD subjects. Conclusions Our findings suggest that alterations of cognitive and executive networks, default mode networks and visual recognition circuits may contribute to the different neural mechanisms between MDD and SD in young adult subjects.

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Cognitive behavioral therapy effects on frontopolar cortex function during future thinking in major depressive disorder: A randomized clinical trial

MDPhD

Umeda

et al. 2022

Journal of Affective Disorders

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Neural and clinical changes of cognitive behavioural therapy versus talking control in patients with major depression: a study protocol for a randomised clinical trial

Cited by 5 publications

References 44 publications

The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial

The effect of cognitive behavioral therapy on future thinking in patients with major depressive disorder: A randomized controlled trial

Is there any difference in the fractional amplitude of low-frequency fluctuations between first episode major depressive disorder patients and subclinical depressive subjects?

Cognitive behavioral therapy effects on frontopolar cortex function during future thinking in major depressive disorder: A randomized clinical trial

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