Neural anti-inflammatory sesquiterpenoids from the endophytic fungus <i>Trichoderma</i> sp. Xy24

Zhang, Min; Zhao, Jian; Liu, Jimei; Chen, Ri-Dao; Xie, Kebo; Chen, Dawei; Feng, Keping; Zhang, Dan; Dai, Jungui

doi:10.1080/10286020.2016.1251908

Cited by 22 publications

(28 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mosher's method (Cao et al, 2014) was tried to determine the absolute configuration of C-7 but failed. Fortunately, a literature survey revealed that the coisolated cyclonerane-type compounds (4-9) and many other similar natural compounds have been reported the same absolute configurations as 2S,3R,6R,7R (Hanson et al, 1975;Kasitu et al, 1992;Li et al, 2007;Wu et al, 2012;Xie et al, 2013;Zhang et al, 2017;Fang et al, 2018;Song et al, 2018). Therefore, based on the biogenetic considerations, compound 3 was proposed to have the same absolute configuration (2S,3R,6R,7R) as the co-isolated compound 9, which was also supported by their similar OR between 3 ([α] 22 D -29.9 (c 1.00, CHCl 3 )) and 9 ([α] 22 D -26.6 (c 1.00, CHCl 3 ); lit.…”

Section: Chemical Identification Of the Isolated Compoundsmentioning

confidence: 99%

Terpenoids From the Coral-Derived Fungus Trichoderma harzianum (XS-20090075) Induced by Chemical Epigenetic Manipulation

et al. 2020

View full text Add to dashboard Cite

The soft coral-derived fungus Trichoderma harzianum (XS-20090075) was found to be a potential strain to produce substantial new compounds in our previous study. In order to explore its potential to produce more metabolites, chemical epigenetic manipulation was used on this fungus to wake its sleeping genes, leading to the significant changes of its secondary metabolites by using a histone deacetylase (HDAC) inhibitor. The most obvious difference was the original main products harziane diterpenoids were changed into cyclonerane sesquiterpenoids. Three new terpenoids were isolated from the fungal culture treated with 10 µM sodium butyrate, including cleistanthane diterpenoid, harzianolic acid A (1), harziane diterpenoid, harzianone E (2), and cyclonerane sesquiterpenoid, 3,7,11-trihydroxy-cycloneran (3), together with 11 known sesquiterpenoids (4-14). The absolute configurations of 1-3 were determined by single-crystal X-ray diffraction, ECD and OR calculations, and biogenetic considerations. This was the first time to obtain cleistanthane diterpenoid and africane sesquiterpenoid from genus Trichoderma, and this was the first chlorinated cleistanthane diterpenoid. These results demonstrated that the chemical epigenetic manipulation should be an efficient technique for the discovery of new secondary metabolites from marinederived fungi.

show abstract

Section: Chemical Identification Of the Isolated Compoundsmentioning

confidence: 99%

Terpenoids From the Coral-Derived Fungus Trichoderma harzianum (XS-20090075) Induced by Chemical Epigenetic Manipulation

et al. 2020

View full text Add to dashboard Cite

show abstract

“…1α-isopropyl-4α,8-dimethylspiro dec-8-ene-3β,7αdiol (26) Trichoderma sp. Xy24 Xylocarpus granatum [15] 10.…”

Section: -Epichaetomugilin I (57)mentioning

confidence: 99%

“…They are characterized by a highly substituted per hydro-isoindolone moiety to which a macrocyclic ring like a carbocycle, a lactone, or a cyclic carbonate is fused [54]. Four AI cytochalasan derivatives [cytochalasin J (12) and H (13), yamchaetoglobosin A (14), and phomopchalasin C (15)] from endophytic fungal sources were reported (▶ Fig. 2).…”

Section: Ai Cytochalasansmentioning

confidence: 99%

See 1 more Smart Citation

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

2020

View full text Add to dashboard Cite

A wide array of therapeutic effects has been exhibited by compounds isolated from natural sources. “Bio-actives of endophytic origin” is a recently explored area that came into recognition over the last 2 decades. Literature search on the secondary metabolites of endophytes have shown several pharmacologically active compounds especially anti-inflammatory compounds, which have been reviewed in the present paper. The article is structured based on the chemical classification of secondary metabolites. The compounds were identified to possess activity against a total of 16 anti-inflammatory targets. The most common targets involved were NO, TNF-α, and inhibition of total ROS. Further, the article gives a detailed insight into the compounds, their endophytic source, and anti-inflammatory target as well as potency. The contents of the article cover all the scientific reports published until Feb. 2019. Thus 118 compounds and 6 extracts have been reported to be obtained from endophytic sources showing anti-inflammatory activities. Amongst these, herbarin, periconianone A, and periconianone B were identified as the most potent compounds in terms of their IC50 values against NO inhibition.

show abstract

“…In another investigation, three new sesquiterpenoids, trichoacorenols B-C and cyclonerodiol B, along with three known ones, isolated from the mangrove plant endophytic fungus Trichoderma sp. Xy24 were reported to exhibit varying degree of anti-inflammatory activity with cyclonerodiol B (153) and (1R,2R,4S,5R,7S)-4-isopropyl-1,8-dimethylspiro [4.5]dec-8-ene-2,7-diol (154) being more potent than curcumin, used as positive control [125].…”

Section: Anti-inflammatory Metabolites Produced By Endophytic Fungi Fmentioning

confidence: 99%

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Toghueo

2019

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Leishmaniases and chronic inflammatory diseases are the cause of millions of deaths in the world each year. The treatment of leishmaniasis is facing serious drawbacks particularly due to the limited number of effective medicines, the resistance, and the toxicity of available drugs. On the other hand, many drugs are used for the management of inflammatory disorders. However, the most commonly prescribed although efficient is highly toxic with multiples side effects. New leads compounds for the development of new anti-leishmanial and anti-inflammatory drugs are needed. Over the past decade, several studies on the potential of endophytes to produce bioactive metabolites have been reported. We are presenting in the present review the status of research from 2000 to 2019 on the anti-leishmanial and anti-inflammatory metabolites isolated from endophytes from diverse habitats. An emphasis was put on existing gaps in the literature to inspire and guide future investigations. We hope that this review will help accelerate the drug discovery against leishmaniases and inflammation-associated disorders.

show abstract

Neural anti-inflammatory sesquiterpenoids from the endophytic fungus Trichoderma sp. Xy24

Cited by 22 publications

References 14 publications

Terpenoids From the Coral-Derived Fungus Trichoderma harzianum (XS-20090075) Induced by Chemical Epigenetic Manipulation

Terpenoids From the Coral-Derived Fungus Trichoderma harzianum (XS-20090075) Induced by Chemical Epigenetic Manipulation

Prospective Leads from Endophytic Fungi for Anti-Inflammatory Drug Discovery

Anti-leishmanial and Anti-inflammatory Agents from Endophytes: A Review

Contact Info

Product

Resources

About