Neural bases of audio-visual integration of socially meaningful information in macaques

Froesel, Mathilda; Gacoin, Maëva; Clavagnier, Simon; Hauser, Marc D.; Goudard, Quentin; Hamed, Suliann Ben

doi:10.21203/rs.3.rs-557983/v1

Cited by 1 publication

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References 102 publications

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“…These projections from multiple pulvinar nuclei in specific brain regions has been a core argument in support of the role of the pulvinar as a modulator (Benarroch, 2015;Saalmann & Kastner, 2011). The pulvinar can thus be a part of several networks and can be recruited differentially as a function of sensory modality or the ongoing cognitive demand (Froesel et al, 2022), thus supporting cognitive flexibility. As a result, another important aspect to keep in mind is that the winner-take-all maps we report here from monkeys at rest could be different during active tasks involving either sensory stimulation or the production of complex behaviors.…”

Section: Discussionmentioning

confidence: 95%

Multiple focal pulvinar projection fields in the macaque cortex

Froesel,

Clavagnier,

Goudard

et al. 2023

Preprint

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The pulvinar, the largest nucleus of the thalamus, is functionally heterogeneous and involved in multiple cognitive functions. It has been proposed to act as a functional hub of cortical processes due to its extensive reciprocal connectivity with the cortex. However, its role in cognition is not fully understood yet. Here, we posit that an improved understanding of its functional connectivity with the cortex is needed to better capture the cognitive functions of this nucleus. To address this question, we characterize the pulvino-cortical functional connectivity along the ventro-dorsal, antero-posterior and medio-lateral axes, using awake resting state data from ten adult macaques. We first report two global cortical functional connectivity gradients along the antero-posterior and ventro-dorsal pulvinar gradients, that match remarkably well the structural connectivity gradients described by anatomical approaches. In addition to these global gradients, multiple local cortical pulvinar projection fields can be identified at the sulci level such as in the lateral sulcus (LS), the intraparietal sulcus (IPS), the principal sulci (PS) and the anterior cingulate cortex (ACC). For most sulci, we show that functional pulvino-cortical projection fields follow the major anatomical axis of these different sulci (e.g. the ventro-dorsal axis for the LS and the antero-posterior axis for the IPS). Other sulci, such as the superior temporal sulcus, the posterior cingulate cortex or the central sulcus, display multiple projection fields from the pulvinar. Although substantial inter-individual differences exist, the general functional connectivity patterns are remarkably consistent across hemispheres and individuals. Overall, we propose that these multiple pulvinar projection fields correspond to a fundamental principle of pulvino-cortical connectivity and that a better understanding of this connectional organization will shed light on the function of pulvino-cortical interactions and the role of the pulvinar in cognition at large.

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Section: Discussionmentioning

confidence: 95%