Neural basis of auditory expectation within temporal cortex

Nazimek, J.M.; Hunter, Michael D.; Hoskin, Robert E.; Wilkinson, Iain D.; Woodruff, Peter

doi:10.1016/j.neuropsychologia.2013.07.019

Cited by 19 publications

(23 citation statements)

References 23 publications

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“…With the superior temporal gyrus including the auditory cortex, and the middle temporal cortex implicated in auditory expectation [39] with projections to the hippocampus and amygdala, activation of these regions in our PTSD group appears to be moderated by threat predictability.…”

Section: Discussionmentioning

confidence: 99%

“…As such, the middle temporal gyrus, with projects to the hippocampus and amygdala, is also of interest in that it is implicated in auditory expectation [39], which in individuals with PTSD, might be hyperactive in response to an aversive auditory stimulus. In addition, recent evidence suggests the inferior parietal lobe is associated with successful emotion regulation [40], and is activated in response to an aversive stimulus (shock) [41].…”

Section: Introductionmentioning

confidence: 99%

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Exploring the Neurocircuitry Underpinning Predictability of Threat in Soldiers with PTSD Compared to Deployment Exposed Controls

Dretsch¹,

Wood²,

Daniel³

et al. 2016

TONIJ

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Background:Prior work examining emotional dysregulation observed in posttraumatic stress disorder (PTSD) has primarily been limited to fear-learning processes specific to anticipation, habituation, and extinction of threat. In contrast, the response to threat itself has not been systematically evaluated.Objective:To explore potential disruption in fear conditioning neurocircuitry in service members with PTSD, specifically in response to predictable versus unpredictable threats.Method:In the current study, active-duty U.S. Army soldiers with (PTSD group; n = 38) and without PTSD (deployment-exposed controls; DEC; n = 40), participated in a fear-conditioning study in which threat predictability was manipulated by presenting an aversive unconditioned stimulus (UCS) that was either preceded by a conditioned stimulus (i.e., predictable) or UCS alone (i.e., unpredictable). Threat expectation, skin conductance response (SCR), and functional magnetic resonance imaging (fMRI) signal to predictable and unpredictable threats (i.e., UCS) were assessed.Results:Both groups showed greater threat expectancy and diminished threat-elicited SCRs to predictable compared to unpredictable threat. Significant group differences were observed within the amygdala, hippocampus, insula, and superior and middle temporal gyri. Contrary to our predictions, the PTSD group showed a diminished threat-related response within each of these brain regions during predictable compared to unpredictable threat, whereas the DEC group showed increased activation.Conclusion:Although, the PTSD group showed greater threat-related diminution, hypersensitivity to unpredictable threat cannot be ruled out. Furthermore, pre-trauma, trait-like factors may have contributed to group differences in activation of the neurocircuitry underpinning fear conditioning.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring the Neurocircuitry Underpinning Predictability of Threat in Soldiers with PTSD Compared to Deployment Exposed Controls

Dretsch¹,

Wood²,

Daniel³

et al. 2016

TONIJ

View full text Add to dashboard Cite

show abstract

“…Some experimental studies directly assessing auditory prediction have been conducted (e.g., neuroimaging studies) and suggest that regions that are activated during prediction of a sound may closely resemble memory representations of sound within the AC. Nazimek et al (2013) found differential brain activity between expected and unexpected sounds, with the later evoking greater left temporal and insula activation. Precision of prediction error processing significantly correlated with neural activity levels in specialized auditory sensory areas used for making perceptual decisions in a study by Hesselmann et al (2010).…”

Section: Evidence For Auditory Predictive Processingmentioning

confidence: 92%

A Review of Auditory Prediction and Its Potential Role in Tinnitus Perception

2018

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“…It has previously been shown that attention exhibits enhanced neural signatures in prefrontal cortical regions (Baluch & Itti, 2011). Recently, functional brain imaging and neurophysiological studies in humans have reported a significantly increased activation in the dlPFC during the processing of visuospatial information and orienting of attention (Baluch & Itti, 2011;Bisley & Goldberg, 2010;Katsuki & Constantinidis, 2012;Nazimek, Hunter, Hoskin, Wilkinson, & Woodruff, 2013). The enhanced activity for attended stimuli might be due to the fact that attention excites neurons responsive to attended features (Hsu et al, 2014).…”

Section: Introductionmentioning

confidence: 99%