Neural cell-types and circuits linking thermoregulation and social behavior

Rogers, Joseph F.; Vandendoren, Morgane; Prather, Jonathan F.; Landen, Jason G.; Bedford, Nicole L.; Nelson, Adam C.

doi:10.1016/j.neubiorev.2024.105667

Cited by 4 publications

(2 citation statements)

References 223 publications

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“…The hyperthermia we observed in group-housed Shank3b mutants might indicate that these animals experience psychosocial stress associated with being housed together. Psychosocial stress is associated with elevated Tb in mice and humans 30,[70][71][72][73] , and many neuropsychiatric disorders, including ASD, are linked to changes in efferent 30 and afferent thermoregulatory pathways 74 . Considering Shank3b mutants are an animal model of ASD 31 , and that around half of individuals with ASD experience social anxiety [75][76][77] , it is possible that Shank3b mutants experience social stress-induced hyperthermic Tb.…”

Section: Discussionmentioning

confidence: 99%

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Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation

Landen,

Vandendoren,

Killmer

et al. 2024

Preprint

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Social thermoregulation is a means of maintaining homeostatic body temperature. While adult mice are a model organism for studying both social behavior and energy regulation, the relationship between huddling and core body temperature (Tb) is poorly understood. Here, we develop a behavioral paradigm and computational tools to identify active-huddling and quiescent-huddling as distinct thermal substates. We find that huddling is an effective thermoregulatory strategy in female but not male groups. At 23°C (room temperature), but not 30°C (near thermoneutrality), huddling facilitates large reductions in Tb and Tb-variance. Notably, active-huddling is associated with bidirectional changes in Tb, depending on its proximity to bouts of quiescent-huddling. Further, group-housed animals lacking the synaptic scaffolding gene Shank3b have hyperthermic Tb and spend less time huddling. In contrast, individuals lacking the cold-sensing gene Trpm8 have hypothermic Tb – a deficit that is rescued by increased huddling time. These results reveal how huddling behavior facilitates acute adjustments of Tb in a state-dependent manner.

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Section: Discussionmentioning

confidence: 99%

“…Despite the association between group housing and energy savings, the precise details of how huddling affects body temperature over the course of the day in adult mice are poorly understood 30 . For example, mice appear to engage in huddling both when awake and when asleep.…”

Section: Introductionmentioning

confidence: 99%

Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation

Landen,

Vandendoren,

Killmer

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation

Landen,

Vandendoren,

Killmer

et al. 2024

Commun Biol

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Decoding temporal thermogenesis: coregulator selectivity and transcriptional control in brown and beige adipocytes

Jeon,

Kim,

Kim

2024

Adipocyte

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In mammals, brown adipose tissue (BAT) and beige adipocytes in white adipose tissue (WAT) play pivotal roles in maintaining body temperature and energy metabolism. In mice, BAT quickly stimulates thermogenesis by activating brown adipocytes upon cold exposure. In the presence of chronic cold stimuli, beige adipocytes are recruited in inguinal WAT to support heat generation. Accumulated evidence has shown that thermogenic execution of brown and beige adipocytes is regulated in a fat depot-specific manner. Recently, we have demonstrated that ubiquitin ligase ring finger protein 20 (RNF20) regulates brown and beige adipocyte thermogenesis through fat-depot-specific modulation. In BAT, RNF20 regulates transcription factor GA-binding protein alpha (GABPα), whereas in inguinal WAT, RNF20 potentiates transcriptional activity of peroxisome proliferator-activated receptor-gamma (PPARγ) through the degradation of nuclear corepressor 1 (NCoR1). This study proposes the molecular mechanisms by which co-regulator(s) selectively and temporally control transcription factors to coordinate adipose thermogenesis in a fat-depot-specific manner. In this Commentary, we provide molecular features of brown and beige adipocyte thermogenesis and discuss the underlying mechanisms of distinct thermogenic processes in two fat depots.

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Neural cell-types and circuits linking thermoregulation and social behavior

Cited by 4 publications

References 223 publications

Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation

Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation

Huddling substates in mice facilitate dynamic changes in body temperature and are modulated by Shank3b and Trpm8 mutation

Decoding temporal thermogenesis: coregulator selectivity and transcriptional control in brown and beige adipocytes

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