Neural Circuit Mechanisms of Social Behavior

Chen, Patrick; Hong, Weizhe

doi:10.1016/j.neuron.2018.02.026

Cited by 436 publications

(347 citation statements)

References 136 publications

(194 reference statements)

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“…MS2 spectra assignment false discovery rate (FDR) of 1% on protein level was achieved by applying the target-decoy database search. Filtering was performed using a Percolator (64bit version, reference 6). For quantification, a 0.02 m/z window centered on the theoretical m/z value of each the six reporter ions and the intensity of the signal closest to the theoretical m/z value was recorded.…”

Section: Methods Detailsmentioning

confidence: 99%

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Multisensory Logic of Infant-Directed Aggression by Males

Isogai

Zheng

Love

et al. 2018

Cell

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Summary Newborn mice emit signals that promote parenting from mothers and fathers, but trigger aggressive responses from virgin males. Although pup-directed attacks by males require vomeronasal function, the specific infant cues that elicit this behavior are unknown. We developed a behavioral paradigm based on reconstituted pup cues and showed that discrete infant morphological features combined with salivary chemosignals elicit robust male aggression. Seven vomeronasal receptors were identified based on infant-mediated activity, and the involvement of two receptors, Vmn2r65, and Vmn2r88, in infant-directed aggression was demonstrated by genetic deletion. Using the activation of these receptors as readouts for biochemical fractionation, we isolated two pheromonal compounds, the submandibular gland protein C and hemoglobins. Unexpectedly, none of the identified vomeronasal receptors and associated cues were specific to pups. Thus, infant-mediated aggression by virgin males relies on the recognition of pup’s physical traits in addition to parental and infant chemical cues.

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Section: Methods Detailsmentioning

confidence: 99%

“…In turn, sensory information and behavioral decisions are gated by the animal’s internal state, enabling sensory inputs to generate motor outputs that are adapted to a given context (Beach, 1942a; Marder, 2012; Chen and Hong, 2018). …”

Section: Introductionmentioning

confidence: 99%

Multisensory Logic of Infant-Directed Aggression by Males

Isogai

Zheng

Love

et al. 2018

Cell

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“…While a failure to reproduce sexually is often connected to physiological or developmental problems of the gonad, gamete or embryo, it is also commonly accepted that problems with sexual reproduction can be linked to physical fitness [1] or behavioral abnormalities [2]. Indeed, inborn social behaviors related to sex, defense and maternal care are elicited by sensory input that is processed by the central nervous system to promote successful reproduction [3].…”

Section: Introductionmentioning

confidence: 99%

Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior

Medrano

Singh

Plautz

et al. 2018

Preprint

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Successful sexual reproduction involves complex, genetically encoded interplay between animal physiology and behavior. The rat provides a highly fecund mammalian model for studying how the brain impacts reproduction. Here, we report a forward genetics screen in rats to identify genes that affect reproduction. A panel of 18 distinct rat strains harboring Sleeping Beauty gene trap mutations were analyzed for the ability to reproduce. As expected, our mutant screen identified genes where reproductive failure was connected to gametogenesis (Btrc, Pan3, Spaca6, Ube2k) and embryogenesis (Alk3, Exoc6b, Slc1a3, Tmx4, Zmynd8). In addition, we identified Atg13 (longevity) and Pclo (neuronal disorders), previously not associated with an inability to conceive.Neurologically, Pclo is known to regulate the size of presynaptic vesicle pools. Here, dominant traits in Pclo mutant rats caused epileptiform activity and affected genes supporting GABAergic synaptic transmission (Gabra6, Gabrg3). Recessive traits in Pclo mutant rats transmitted altered reproductive behavior, as homozygous Pclo mutant rats produced gametes but neither sex would mate with wildtype rats. Pclo mutant rat behavior was linked to endophenotypes signifying compromised brain-gonad crosstalk via disturbed GnRH signaling and allelic markers for major depressive disorder in humans (Grm5, Htr2a, Sorcs3, Negr1, Drd2). Thus, by rat genetics, we identified Pclo as a candidate presynaptic factor required for reproduction. Author SummaryPiccolo gene mutations have previously been identified in human cohorts diagnosed with behavioral syndromes that impact one's emotions, including depression and bipolar disorder.Although studies in human populations implicate changes to Piccolo's DNA sequence to enhanced susceptibility for behavioral disorders, studies in mouse models have yet to link Piccolo mutations to altered behavior. Here, by a novel genetics approach, we report Piccolo mutationdependent effects on reproductive behavior in rats, a finding that may turn out to be relevant to the behavioral effects that are associated with human Piccolo gene mutations. Thus, research aimed at understanding how Piccolo functions to regulate reproduction in rats could prove pivotal in our ability to understand neurological mechanisms that influence human emotions.pathologies, and in males, Atg13 gt/gt was further complicated with abnormal spermatozoa. Thus, the cause of infertility of Atg13 gt/gt rats is a cumulation of general fitness problems. Compromised neurotransmission in Pclo mutantsDespite their reproductive failure (Fig 2A), Pclo gt/gt mutant rats did not display any obvious dysfunction during gametogenesis (S2A and S2C Fig). Numbers of epididymal spermatozoa from Pclo gt/gt rats were relatively normal (Fig 2C). However, spermatozoa from Pclo gt/gt rats were not found in vaginal swabs of WT females (6 of 6 breeder pairs) (Fig 4A, and spermatozoa from WT males were not detected in Pclo gt/gt females (6 of 6 breeder pairs) (Fig 4A), suggesting that the mating did not actuall...

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“…The formation of social hierarchy arises from repeated social activities between individuals, which is affected by environmental pressures (Chen & Hong, 2018). This consequently forms neural circuits that supposedly regulate behaviors and physiological responses of individuals (Miller et al, 2017;Munuera, Rigotti, & Salzman, 2018;Sapolsky, 2005).…”

Section: Neur Al Circu Its Underlying So Cial S Tatus In Animal S Amentioning

confidence: 99%

Social status and modern‐type depression: A review

2019

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BackgroundsSocial hierarchy is one of the most influential social structures employed by social species. While dominants in such hierarchies can preferentially access rich resources, subordinates are forced into lower social statuses and lifestyles with inferior resources. Previous studies have indicated that the social rank regulates social behaviors and emotion in a variety of species, whereby individual organisms live within the framework of their ranks. However, in human societies, people, particularly young men, who cannot accept their own social status may show social withdrawal behaviors such as hikikomori to avoid confronting their circumstances.MethodsThis article reviews the neural mechanisms underlying social status identified in animal studies with rodents and primates, and assesses how social rank affects animal's social behaviors and emotion which may be relevant to modern type depression.ResultsSeveral brain regions such as medial prefrontal cortex are implicated in the formation of animal's social status, which leads to the differences in vulnerability and resilience to social stress.ConclusionOn the basis of these findings, we propose that physical interventions such as voluntary exercise, diet, transcranial direct current stimulation, and psychotherapy, rather than psychotropic drugs, may be useful therapeutic approaches for modern type depression, which is a typical example of social status conflict and a phenotype of adjustment disorder to the traditional hierarchical social order.

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Neural Circuit Mechanisms of Social Behavior

Cited by 436 publications

References 136 publications

Multisensory Logic of Infant-Directed Aggression by Males

Multisensory Logic of Infant-Directed Aggression by Males

Mutant screen for reproduction unveils depression-associated Piccolo’s control over reproductive behavior

Social status and modern‐type depression: A review

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