Neural circuitry among connecting the hippocampus, prefrontal cortex and basolateral amygdala in a mouse depression model: Associations correlations between BDNF levels and BOLD – fMRI signals

Huang, Peng; Gao, Tingting; Dong, Zhaoyang; Zhou, Chuying; Lai, Yu‐Ling; Pan, Ting; Liu, Yuan; Zhao, Xiaoshan; Sun, Xuegang; Hua, Heyu; Wen, Gen; Gao, Lei; Lv, Zhen

doi:10.1016/j.brainresbull.2018.06.019

Cited by 39 publications

(27 citation statements)

References 34 publications

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“…The inside/outside counterparts indicate causalities. Here, each HTB circuit comprising comorbid-like pro les is different from the 19 other circuits identi ed from BOLD activated areas related to pathogenesis, therapy, and pharmacology for single diseases [17][18][19][20][21][22][23][24][25][26][27][28][29]. FS is widely used as a behavioral paradigm to assess depressive behaviors [52], but hypomotility has been overlooked.…”

Section: Discussionmentioning

confidence: 99%

“…7.0 T fMRI BOLD foci can precisely discriminate activity of neural populations in the sensorimotor cortex at 1.5 mm scale with high spatial delity, similar to electrophysiological determination of activated foci [46]. We address which foci are activated based on antagonist studies, using stress and SSRIs as control [17][18][19][20][21][22][23][24][25][26][27][28][29]. FS, MH, and ghrelin antagonist [D-Lys3]-GHRP-6 were used for activation and inactivation.…”

Section: Discussionmentioning

confidence: 99%

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Prokinetic meranzin hydrate from Chaihu-Shugan-San improves depression-like behaviors and hypomotility in rats via ghrelin and neurocircuitry

Zhang

Chen

et al. 2020

Preprint

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Background Depression and functional dyspepsia (FD) are characterized by comorbidity, overlapping depression, and nausea. The pathogenesis of depression and FD is mediated by α2-adrenoreceptor and/or ghrelin. Antidepressant (A) or prokinetic (P) agents are numerous, but few have been investigated in this context. Ancient Gan-zhu-shu-xie (GZSX), whose representative traditional Chinese medicine(TCM) is Chaihu-Shugan-San (CSS), may exert antidepressant effects with prokinetic meranzin hydr-ate (MH) via α2-adrenoreceptors in the acute forced swimming (FS) test in rats.Therefore, the main aim of the study is to investigate the acute antidepressant and prokinet-ic effects of CSS and MH after acutely FS on rats, and its possible mechanism. Methods FS rats were treated with CSS, MH, fluoxetine, ghrelin antagonist [D-Lys3]-GHRP-6, and take a series of behavior tests and gastrointestina motility tests, and via 7.0 T fMRI-BOLD signal, compared with well-known mechanism of positive control. Results MH has similar effects to CSS-stimulated deactivation when comparedto those of fluoxetine (4.02-fold for hippocampus and 1.45-fold for thalamus). The ghrelin antagonist [D-Lys3]-GHRP-6 synchronously inhibited A&P and BOLD HTB foci. Prokinetic mosapride had effects on the thalamus and basal ganglia but not the hippocampus. Within the HTB, the hippocampus is implicated in depression and FD. Conclusion These data show that on acute FS-stimulated DB&H, MH-induced rapid A&P, and ghrelin-related regulation coupled to BOLD signals in brain areas before, providing insight into a unified theory of depression pathogenesis and pharmacotherapy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Prokinetic meranzin hydrate from Chaihu-Shugan-San improves depression-like behaviors and hypomotility in rats via ghrelin and neurocircuitry

Zhang

Chen

et al. 2020

Preprint

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“…As previously described, the mice were anesthetized using isoflurane in two stages: the induction stage (ratio of 1% oxygen + 3% isoflurane) and the continuous anesthesia stage (0.5% oxygen + 2.5% isoflurane). Afterward, mice were fixed to minimize head motion using a custom‐made MRI‐compatible cradle with ear and bite bars.…”

Section: Methodsmentioning

confidence: 99%

“…Echo‐planar imaging with a low spatial and high temporal resolution was used for phase‐image acquisition. Parameters were set as in previous studies: protocol = ax − T1w, resolution = 0.14 × 0.14 × 1.0 mm, matrix size = 192 × 128, slice thickness = 1.40 mm, slice gap = 0.10 mm, repetition time = 603.94 ms, echo time = 9.01 ms, averages = 32, scan time = 5 min 10 s, repetitions = 1, and volume = 1. A statistical parametric mapping toolbox (plug‐in), the SpmratIHEP toolkit, was used to preprocess the phase images …”

Section: Methodsmentioning

confidence: 99%

Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice

Huang

Dong

et al. 2019

Neuropathology

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The aim of this study is to explore the macroscale neural mechanisms of the antidepressant effects of Xiaoyaosan, a traditional Chinese herbal formula. We analyzed blood oxygen level‐dependent (BOLD) functional magnetic resonance imaging signals. To further minimize the hemodynamic variations of BOLD signals and analyze the intra‐region neural activity or temporal coherence, we employed the newly developed regional homogeneity (ReHo) approach to determine aberrant functional connectivity using the chronic unpredictable mild stress (CUMS) mouse model of depression and to also explore the brain‐region rescue effect of modified Xiaoyaosan (MXYS) in such mice. We found the aberrant ReHo in CUMS mice replicated previous discoveries in patients with depression. Intriguingly, MXYS only normalized several limbic regions, which suggests the essential roles of these regions in mediating the antidepressant effects of MXYS. Our results provide a reliable framework for the use of ReHo analysis with animal models of depression and further suggest a new perspective to elucidate the antidepressant effects of MXYS.

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“…Thoracic aortas were removed and immediately used for vascular reactivity studies. Brain regions that are connected to the neuroanatomical circuit involved in depression namely the prefrontal cortex (PFC) and hippocampus (Hip) (25) were collected and stored at -80 °C until homogenization in 7 volumes of ice-cold buffer, centrifugation and determination of protein concentration (Lowry method) in supernatant. Hind paws were removed and placed in 4% formalin until assessment of radiographs.…”

Section: Tissue Collectionmentioning

confidence: 99%

Vascular and cerebral benefits of Tofacitinib in rheumatoid arthritis: evidence in rat adjuvant-induced arthritis

Totoson¹,

Quirié²,

Pedard³

et al. 2020

Preprint

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Background: To determine vascular and cerebral effects of Tofacitinib in the adjuvant-induced arthritis (AIA) model in rat.Methods: At the first signs of arthritis (day 10-12 post-immunization), Tofacitinib (10 mg/kg s.c., twice daily) or vehicle were administered for 3 weeks in AIA rats. A group of non AIA served as controls. Body weights and arthritis scores were daily monitored. Anhedonia was explored with the saccharin preference test at day 4 (preclinical), day 11 (early) and day 28 (acute arthritis) post-immunization. At the end of the treatment, aorta, brain and blood were collected for analysis of endothelial function using acetylcholine (Ach)-induced relaxation, brain-derived neurotrophic factor (BDNF) protein levels in the hippocampus (Hip) and prefrontal cortex (PFC), and IL-1β, TNFα, IL-17A plasma levels. Radiographic score of paws was also assessed. Results: As compared to vehicle, Tofacitinib reduced body weight loss, arthritis and radiographic scores (p<0.001) but did not change plasma levels of pro-inflammatory cytokines. Tofacitinib fully prevented AIA-associated reduction in Ach-induced relaxation. As compared to controls, vehicle-treated AIA exhibited low BDNF levels in PFC (p<0.001) and anhedonia at all times examined (p<0.05). Tofacinib did not improve anhedonia, but resulted in elevation of BDNF levels both in PFC (p<0.05) and Hip (p<0.001). A positive correlation was observed between brain BDNF levels and endothelial function (p<0.05).Conclusion: Restoration of normal endothelial function and elevation of brain BDNF levels by Tofacitinib in AIA rats support a positive effect of this new antirheumatic drug on cardiovascular and neuropsychiatric comorbidities of rheumatoid arthritis.

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Neural circuitry among connecting the hippocampus, prefrontal cortex and basolateral amygdala in a mouse depression model: Associations correlations between BDNF levels and BOLD – fMRI signals

Cited by 39 publications

References 34 publications

Prokinetic meranzin hydrate from Chaihu-Shugan-San improves depression-like behaviors and hypomotility in rats via ghrelin and neurocircuitry

Prokinetic meranzin hydrate from Chaihu-Shugan-San improves depression-like behaviors and hypomotility in rats via ghrelin and neurocircuitry

Modified Xiaoyaosan reverses aberrant brain regional homogeneity to exert antidepressive effects in mice

Vascular and cerebral benefits of Tofacitinib in rheumatoid arthritis: evidence in rat adjuvant-induced arthritis

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