Neural Circuitry: Architecture and Function—A Fiber Dissection Study

Shah, Abhidha; Goel, Aimee; Jhawar, Sukhdeep Singh; Patil, Abhinandan; Rangnekar, Ranjit D; Goel, Atul

doi:10.1016/j.wneu.2019.01.139

Cited by 33 publications

(12 citation statements)

References 16 publications

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“…In the original Klingler's method, leptomeninges and vessels (Fig. 3 A.1) are removed just before 1 or after 15 freezing, but in any case before dissection (Fig. 3 A.2).…”

Section: Methodsmentioning

confidence: 99%

Using ex vivo arterial injection and dissection to assess white matter vascularization

Smirnov

Maldonado

Destrieux

2023

Sci Rep

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Advances in the techniques for assessing human cerebral white matter have recently contributed to greater attention to structural connectivity. Yet, little is known about the vascularization of most white matter fasciculi and the fascicular composition of the vascular territories. This paper presents an original method to label the arterial supply of macroscopic white matter fasciculi based on a standardized protocol for post-mortem injection of colored material into main cerebral arteries combined with a novel fiber dissection technique. Twelve whole human cerebral hemispheres obtained post-mortem were included. A detailed description of every step, from obtaining the specimen to image acquisition of its dissection, is provided. Injection and dissection were reproducible and manageable without any sophisticated equipment. They successfully showed the arterial supply of the dissected fasciculi. In addition, we discuss the challenges we faced and overcame during the development of the presented method, highlight its originality. Henceforth, this innovative method serves as a tool to provide a precise anatomical description of the vascularization of the main white matter tracts.

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“…In the original Klingler's method, leptomeninges and vessels (Fig. 3 A.1) are removed just before 1 or after 15 freezing, but in any case before dissection (Fig. 3 A.2).…”

Section: Methodsmentioning

confidence: 99%

Using ex vivo arterial injection and dissection to assess white matter vascularization

Smirnov

Maldonado

Destrieux

2023

Sci Rep

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“…According to a standardized protocol, specimens xed to PLA holders underwent modi ed ber dissection to expose white matter bers and the injected vasculature. In the original Klingler's method, leptomeninges and vessels are removed just before 1 or after 15 freezing, but in any case before dissection (Fig. 3A.2).…”

Section: Fiber Dissectionmentioning

confidence: 99%

“…Following the dissection protocol described by Zemmoura et al 1 , we exposed super cial (short association U-bers) and middle groups of the cerebral white matter ber system 15 . The latter consisted of the 1) SLF-II and SLF-III, respectfully, connecting the middle and inferior frontal gyri with the inferior parietal lobule, 2) AF in a C-shape appearance, connecting the inferior frontal gyrus to the temporal cortex, 3) ILF, underlying the inferior temporal and fusiform gyri and connecting the temporal and occipital poles, 4) IFOF in an hourglass-shaped appearance, connecting the cortex of the frontal and occipital lobes, 5) UF, linking the orbitofrontal cortex and the cortex of the temporal pole, and 6) sagittal stratum.…”

Section: Fiber Dissectionmentioning

confidence: 99%

“…Next, the putamen and then globus pallidus were removed, thus, exposing the internal capsule and the anterior commissure. We proceeded the dissection further until the structures of the vertical and central white matter ber system groups 15 were taken out, nally leaving only the cingulum and medial super cial U-bers. It was possible to follow white matter vascularization and observe distribution territories of major cerebral arteries during every dissection step.…”

Section: Fiber Dissectionmentioning

confidence: 99%

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Fibravasc: a method to assess the vascularization of main white matter fiber tracts

Smirnov

Maldonado

Destrieux

2022

Preprint

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Advances in the techniques for assessing human cerebral white matter have recently contributed to greater attention to structural connectivity. Yet, little is known about the vascularization of most white matter fasciculi and the fascicular composition of the vascular territories. This paper presents an original method to label the arterial supply of macroscopic white matter fasciculi based on a standardized protocol for post-mortem injection of colored material combined with a novel fiber dissection technique. A detailed description of every step, from obtaining the specimen to image acquisition of its dissection, is provided. Injection and dissection results show the reproducibility and feasibility of the protocol. In addition, we discuss the challenges we faced and overcame during the development of the presented method, highlight its originality, and briefly review the white matter's place in modern clinical practice and research.

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“…This failure of left-sided exploration may be understood by considering the function of the brain’s attention networks [ 46 ]. These networks comprise the areas connected by a white matter tract known as the superior longitudinal fasciculus [ 47 , 48 , 49 , 50 ] that runs between the front (frontal cortex) and back (temporal and parietal cortices) of the brain. This tract is divided into three parts.…”

Section: Information and Experimental Designmentioning

confidence: 99%

Inferring What to Do (And What Not to)

Parr

2020

Entropy

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In recent years, the “planning as inference” paradigm has become central to the study of behaviour. The advance offered by this is the formalisation of motivation as a prior belief about “how I am going to act”. This paper provides an overview of the factors that contribute to this prior. These are rooted in optimal experimental design, information theory, and statistical decision making. We unpack how these factors imply a functional architecture for motivated behaviour. This raises an important question: how can we put this architecture to work in the service of understanding observed neurobiological structure? To answer this question, we draw from established techniques in experimental studies of behaviour. Typically, these examine the influence of perturbations of the nervous system—which include pathological insults or optogenetic manipulations—to see their influence on behaviour. Here, we argue that the message passing that emerges from inferring what to do can be similarly perturbed. If a given perturbation elicits the same behaviours as a focal brain lesion, this provides a functional interpretation of empirical findings and an anatomical grounding for theoretical results. We highlight examples of this approach that influence different sorts of goal-directed behaviour, active learning, and decision making. Finally, we summarise their implications for the neuroanatomy of inferring what to do (and what not to).

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Neural Circuitry: Architecture and Function—A Fiber Dissection Study

Cited by 33 publications

References 16 publications

Using ex vivo arterial injection and dissection to assess white matter vascularization

Using ex vivo arterial injection and dissection to assess white matter vascularization

Fibravasc: a method to assess the vascularization of main white matter fiber tracts

Inferring What to Do (And What Not to)

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