Neural Circuitry of Wakefulness and Sleep

Scammell, Thomas E.; Arrigoni, Elda; Lipton, Jonathan O.

doi:10.1016/j.neuron.2017.01.014

Cited by 725 publications

(694 citation statements)

References 197 publications

(261 reference statements)

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“…It is currently understood that subcortical neuromodulatory neurons in the brainstem, midbrain, hypothalamus, and basal forebrain interact with each other, the thalamus, and the cortex to drive behavioral, physiological, and electrocortical sleep/wake states. Key components of the wake regulatory systems are the: (1) monoaminergic neurons (including noradrenergic, dopaminergic, serotonergic, and histaminergic) of the locus coeruleus (LC), ventral tegmental area (VTA), dorsal raphe nucleus (DRN), and tuberomammillary nucleus (TMN); (2) cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei (PPT/LDT), and basal forebrain (BF), and (3) hypocretinergic (Hcrt; also known as orexinergic) neurons of the lateral hypothalamus (LH) [3]. A balance between activity in wake-promoting and sleep-promoting neurons [4 • ], such as the GABAergic neurons of the ventrolateral preoptic area (VLPO) and brainstem, has been hypothesized as a model to understand sleep-to-wake transitions [5].…”

Section: Neuronal Circuitry Of Sleep/wake State Regulationmentioning

confidence: 99%

To sleep or not to sleep: neuronal and ecological insights

Eban-Rothschild

Giardino

Lecea

2017

Current Opinion in Neurobiology

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Daily, animals need to decide when to stop engaging in cognitive processes and behavioral responses to the environment, and go to sleep. The main processes regulating the daily organization of sleep and wakefulness are circadian rhythms and homeostatic sleep pressure. In addition, motivational processes such as food seeking and predator evasion can modulate sleep/wake behaviors. Here, we discuss the principal processes regulating the propensity to stay awake or go to sleep—focusing on neuronal and behavioral aspects. We first introduce the neuronal populations involved in sleep/wake regulation. Next, we describe the circadian and homeostatic drives for sleep. Then, we highlight studies demonstrating various effects of motivational processes on sleep/wake behaviors, and discuss possible neuronal mechanisms underlying their control.

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Section: Neuronal Circuitry Of Sleep/wake State Regulationmentioning

confidence: 99%

To sleep or not to sleep: neuronal and ecological insights

Eban-Rothschild

Giardino

Lecea

2017

Current Opinion in Neurobiology

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“…Considerable progress has been made in identifying molecularly defined neuronal populations and circuit elements involved in the control of parenting and other instinctive behaviors and physiological states such as aggression [33,34,62,63], mating [33,62], sleep [28,64], feeding [21,65] and thermoregulation [66,67]. However, several challenges lie ahead.…”

Section: Discussionmentioning

confidence: 99%

“…Recent findings from partially mapped circuits controlling feeding [21–26], sleep [27,28] and defensive behaviors [29,30] have illustrated possible organizational principles of circuit nodes controlling instinctive behaviors. Agouti-related peptide — expressing neurons in the arcuate nucleus (ARC AgRP ) send out non-branching projections, several of which are sufficient to independently evoke feeding [21].…”

Section: Towards a Circuit-level Analysis Of Parental Behaviormentioning

confidence: 99%

Neural control of parental behaviors

Kohl

Dulac

2018

Current Opinion in Neurobiology

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Parenting is a multicomponent social behavior that is essential for the survival of offspring in many species. Despite extensive characterization of individual brain areas involved in parental care, we do not fully understand how discrete aspects of this behavior are orchestrated at the neural circuit level. Recent progress in identifying genetically specified neuronal populations critical for parenting, and the use of genetic and viral tools for circuit-cracking now allow us to deconstruct the underlying circuitry and, thus, to elucidate how different aspects of parental care are controlled. Here we review the latest advances, outline possible organizational principles of parental circuits and discuss future challenges.

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“…Neurotransmitters are molecules produced by brain cells (neurons) that send chemical messages to other cells to alter their function. One of the most common neurotransmitters in the brain and body is called acetylcholine [1]. Acetylcholine is produced by many different types of neurons, including those that control sleep and wakefulness.…”

Section: Figurementioning

confidence: 99%

Do Cigarettes Have Long-lasting Effects on Children’s Sleep?

Borniger¹,

Don²,

Boyd³

et al. 2018

Front. Young Minds

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Sleep is an important part of overall health and well-being. Without proper sleep, our thoughts get foggy, and we have trouble remembering things. On top of that, other parts of our bodies start to work less efficiently. For example, messed up sleep can cause changes in immune or metabolic systems that can promote disease or make certain diseases worse! Despite what we already know, not all the causes of sleep disruption are well understood. We all know now that smoking cigarettes is bad for your health, and a lot of evidence suggests that pregnant mothers who smoke cigarettes have children that have sleep problems. These problems may promote disease or interfere with life when the child grows up. Here, we will discuss three things: (1) How do we know what parts of the brain control sleep and how can we measure sleep in animals? (2) How do cigarettes alter the function of the brain and body? and (3) How can a smoking mother alter her child's sleep all the way into adulthood?

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Neural Circuitry of Wakefulness and Sleep

Cited by 725 publications

References 197 publications

To sleep or not to sleep: neuronal and ecological insights

To sleep or not to sleep: neuronal and ecological insights

Neural control of parental behaviors

Do Cigarettes Have Long-lasting Effects on Children’s Sleep?

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