2023
DOI: 10.1523/jneurosci.0910-23.2023
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Neural Circuits Underlying Multifeature Extraction in the Retina

Prathyusha Ravi Chander,
Laura Hanson,
Pavitra Chundekkad
et al.

Abstract: Classic ON-OFF direction-selective ganglion cells (DSGCs) that encode the four cardinal directions were recently shown to also be orientation-selective. To clarify the mechanisms underlying orientation selectivity we employed a variety of electrophysiological, optogenetic, and gene knock-out strategies to test the relative contributions of glutamate, GABA, and acetylcholine (ACh) input that are known to drive DSGCs, in male and female mouse retinas. Extracellular spike recordings revealed that DSGCs respond pr… Show more

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