Neural control of affiliative touch in prosocial interaction

Wu, Ye; Dang, James; Kingsbury, Lyle; Zhang, Mingmin; Sun, Fangmiao; Hu, Rongfeng K.; Hong, Weizhe

doi:10.1038/s41586-021-03962-w

Cited by 90 publications

(77 citation statements)

References 51 publications

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“…As such, studies have also implicated oxytocin signaling in the MeA in recognition of conspecifics and global deletion of oxytocin resulted in a specific deficit in social memory, which was rescued by infusion of oxytocin into the MeA (Ferguson et al, 2001 ). A recent study identified GABAergic Tac1 neurons of the MeA that mediate affiliative touch and consolation behavior directed towards a distressed conspecific via projections to the medial preoptic area (Wu et al, 2021 ).…”

Section: Neurobiology Of Prosocial Behaviorsmentioning

confidence: 99%

“…Projections from the supramamillary nucleus (SuM) to the CA2 subdivision of the hippocampus are strongly activated by novel social encounters and activation of the SuM-CA2 pathway can drive exploratory behaviors linked to social novelty (Chen et al, 2020 ). One recent study identified direct inputs to CA2 Amigo2 cells from glutamatergic medial septum neurons that are modulated by 5-HT sourced from the median raphe (Wu et al, 2021 ). Interestingly, social memory was found to require 5-HT-mediated excitation of medial septal inputs to Amigo2 cells.…”

Section: Neurobiology Of Prosocial Behaviorsmentioning

confidence: 99%

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Friend of the Devil: Negative Social Influences Driving Substance Use Disorders

Pomrenze

Paliarin

Maiya

2022

Front. Behav. Neurosci.

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Substance use disorders in humans have significant social influences, both positive and negative. While prosocial behaviors promote group cooperation and are naturally rewarding, distressing social encounters, such as aggression exhibited by a conspecific, are aversive and can enhance the sensitivity to rewarding substances, promote the acquisition of drug-taking, and reinstate drug-seeking. On the other hand, withdrawal and prolonged abstinence from drugs of abuse can promote social avoidance and suppress social motivation, accentuating drug cravings and facilitating relapse. Understanding how complex social states and experiences modulate drug-seeking behaviors as well as the underlying circuit dynamics, such as those interacting with mesolimbic reward systems, will greatly facilitate progress on understanding triggers of drug use, drug relapse and the chronicity of substance use disorders. Here we discuss some of the common circuit mechanisms underlying social and addictive behaviors that may underlie their antagonistic functions. We also highlight key neurochemicals involved in social influences over addiction that are frequently identified in comorbid psychiatric conditions. Finally, we integrate these data with recent findings on (±)3,4-methylenedioxymethamphetamine (MDMA) that suggest functional segregation and convergence of social and reward circuits that may be relevant to substance use disorder treatment through the competitive nature of these two types of reward. More studies focused on the relationship between social behavior and addictive behavior we hope will spur the development of treatment strategies aimed at breaking vicious addiction cycles.

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Section: Neurobiology Of Prosocial Behaviorsmentioning

confidence: 99%

Section: Neurobiology Of Prosocial Behaviorsmentioning

confidence: 99%

Friend of the Devil: Negative Social Influences Driving Substance Use Disorders

Pomrenze

Paliarin

Maiya

2022

Front. Behav. Neurosci.

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“…1C). The blocking of enhanced recall when the stressed cagemate can not see the other mice suggests the intriguing possibility that distressed mice emit different auditory-olfactory stimuli based on their perceived social context; i.e., producing more distressed signals when familiar conspecifics are nearby and available to buffer this distress (29).…”

Section: Post-learning Social Stress Amplifies Behavioral Expression Of Fear Recall In a Sex-dependent Mannermentioning

confidence: 99%

“…It is crucial to note that physical interaction with a stressed familiar cagemate is not simply a heightened version of either the passive exposure to stressful emissions or of the interaction with an unfamiliar juvenile intruder mouse. In light of recent work on social buffering (30,31) especially via physical interactions such as allogrooming (29), we hypothesized that full interaction permitted the experimental mice to buffer the shocked cagemate's distress, and the subsequently reduced stress response failed to evoke the strengthening of cagemates' fear recall. To test this hypothesis directly, we repeated the 1-Way Mirror protocol but placed one of the cagemates on the same side as the shocked mouse, thus allowing social buffering of the shocked mouse but maintaining the same conditions for the experimental mice on the other side (Socially Buffered group).…”

Section: Post-learning Social Stress Amplifies Behavioral Expression Of Fear Recall In a Sex-dependent Mannermentioning

confidence: 99%

Social Reactivation of Fear Engrams Enhances Memory Recall

Finkelstein

Leblanc

Cole

et al. 2021

Preprint

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The power of one's social environment to bidirectionally modulate cognitive abilities is well documented, but the processes by which social experiences impact the cellular substrates of memory remain unknown. Here we show that social interactions and exposure to ambient stimuli emitted by stressed conspecifics, but not individually experienced physical stress, enhance the recall and reinstatement of previously acquired fear memories. Activity-dependent tagging of cells in the dentate gyrus of the hippocampus during fear learning revealed that these ensembles were endogenously reactivated during the social, but not directly stressful, experiences. These reactivated cells were revealed to be functional engrams, as optogenetic stimulation of the cells active during the social experience was sufficient to drive fear-related behaviors only in animals that had previously been fear conditioned. Our findings suggest that social encounters can reactivate pre-existing engrams and thereby strengthen discrete memories.

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“…Indeed, in calcium imaging studies, fluorescence microendoscopes 30 – 37 have been optimized for monitoring neuronal ensemble activity in various small animals expressing genetically encoded calcium indicators (GECIs). 38 , 39 State-of-the-art models that satisfy different imaging requirements include nVista (pioneering epifluorescence microscope, weighing 1.8 g and up depending on the unit), 31 UCLA miniScope V4 (pioneering open-source platform; high-resolution achromatic optics and automatic focus, 2.6 g), 36 NINscope (multiregion imaging, 1.6 g), 34 wireless miniScope (untethered, 4.5 g), 32 , 35 and FinchScope (designed for zebrafinch investigations, 1.8 g). 37 These devices show promise and continue to bring mechanistic insights into both functional and dysfunctional activity within various superficial, subcortical, and deep brain regions, including, but not limited to the cortex, 31 subfields of the hippocampus, 32 , 33 the cerebellum, 34 and the striatum.…”

Section: Introductionmentioning

confidence: 99%

Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice

et al. 2022

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. Significance: Intrinsic optical signals (IOS) generated in the cortical tissue as a result of various interacting metabolic processes are used extensively to elucidate the underlying mechanisms that govern neurovascular coupling. However, current IOS measurements still often rely on bulky, tabletop imaging systems, and there remains a dearth of studies in freely moving subjects. Lightweight, miniature head-mounted imaging devices provide unique opportunities for investigating cortical dynamics in small animals under a variety of naturalistic behavioral settings. Aim: The aim of this work was to monitor IOS in the somatosensory cortex of wild-type mice by developing a lightweight, biocompatible imaging device that readily lends itself to animal experiments in freely moving conditions. Approach: Herein we describe a method for realizing long-term IOS imaging in mice using a 0.54-g, compact, CMOS-based, head-mounted imager. The two-part module, consisting of a tethered sensor plate and a base plate, allows facile assembly prior to imaging sessions and disassembly when the sensor is not in use. LEDs integrated into the device were chosen to illuminate the cortical mantle at two different wavelengths in the visible regime ( : 535 and 625 nm) for monitoring volume- and oxygenation state-dependent changes in the IOS, respectively. To test whether the system can detect robust cortical responses, we recorded sensory-evoked IOS from mechanical stimulation of the hindlimbs (HL) of anesthetized mice in both acute and long-term implantation conditions. Results: Cortical IOS recordings in the primary somatosensory cortex hindlimb receptive field (S1HL) of anesthetized mice under green and red LED illumination revealed robust, multiphasic profiles that were time-locked to the mechanical stimulation of the contralateral plantar hindpaw. Similar intrinsic signal profiles observed in S1HL at 40 days postimplantation demonstrated the viability of the approach for long-term imaging. Immunohistochemical analysis showed that the brain tissue did not exhibit appreciable immune response due to the device implantation and operation. A proof-of-principle imaging session in a freely behaving mouse showed minimal locomotor impediment for the animal and also enabled estimation of blood flow speed. Conclusions: We demonstrate the utility of a miniature cortical imaging device for monitoring IOS and related hemodynamic processes in both anesthetized and freely moving mice, cueing potential for applications to some neuroscientific studies of sensation and naturalistic behavior.

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Neural control of affiliative touch in prosocial interaction

Cited by 90 publications

References 51 publications

Friend of the Devil: Negative Social Influences Driving Substance Use Disorders

Friend of the Devil: Negative Social Influences Driving Substance Use Disorders

Social Reactivation of Fear Engrams Enhances Memory Recall

Modular head-mounted cortical imaging device for chronic monitoring of intrinsic signals in mice

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