Neural Control of Renal Function

Moss, Nicholas; Colindres, Rómulo E.; Gottschalk, Carl W.

doi:10.1002/cphy.cp080124

Cited by 11 publications

(12 citation statements)

References 467 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These observations are similar to those that were previously reported in the normal, conscious, chronically instrumented rats [1]. The functional importance of renal nerves in mediating renal excretion is consistent with the anatomical evidence for direct neural innervation of the proximal and distal convolute tubules, the thick ascending limb of Henle's loop and cortical collecting tubules [24].…”

Section: Discussionsupporting

confidence: 81%

Renal and Cardiovascular Effects of Renal Denervation in Conscious Rats after Adenosine Administration and Nitric Oxide Synthase Inhibition

Girchev

Mikhov²,

Markova³

2002

Kidney Blood Press Res

View full text Add to dashboard Cite

The role of renal nerves on renal and cardiovascular responses to adenosine administration and/or acute NO synthase inhibition was investigated. Conscious male Wistar rats with implanted catheters in femoral artery for blood pressure registration, femoral vein for drug infusion and bladder for urine collection were used. Adenosine was applied i.v. (1.0 mg/kg BW bolus) followed by infusion of 0.1 mg/kg·min, and/or nitric oxide synthase inhibition (NOSI) was performed by i.v. administration of 10 mg/kg BW N-Ω-nitro-L-arginine methyl ester (L-NAME) before and 1 week after bilateral renal denervation (BRD). NOSI decreased HR and increased SAP, MAP and DAP both in intact and BRD rats. Baroreflex sensitivity increased in intact and BRD rats. Adenosine did not change HR, blood pressure or baroreflex sensitivity in intact as well as BRD rats. NOSI increased V, VU_Na and VU_CI in intact rats but decreased V and did not alter VU_Na and VU_CI in BRD rats. Adenosine increased V, VU_CI and C_cr in intact rats but did not change renal excretory function in BRD rats. Combined application of adenosine and L-NAME led to a dramatic increase of V, VU_Na, VU_Cl and C_cr in intact rats. However, VU_Na and VU_CI in BRD rats were lower as compared to intact rats. Therefore, changes in renal excretory function seen after NOSI are not exclusively the result of pressure diuresis and natriuresis but in some way are dependent on renal nerves. Renal denervation attenuates the renal excretory response to adenosine. Sympathetic nervous system is important in mediating the effects of adenosine and/or NO on renal excretory function. Renal denervation did not change the pattern of baroreflex sensitivity after adenosine and/or L-NAME administration.

show abstract

Section: Discussionsupporting

confidence: 81%

Renal and Cardiovascular Effects of Renal Denervation in Conscious Rats after Adenosine Administration and Nitric Oxide Synthase Inhibition

Girchev

Mikhov²,

Markova³

2002

Kidney Blood Press Res

View full text Add to dashboard Cite

show abstract

“…Thus, renal nerve activity may affect renal hemodynamics, renin release, and sodium and water excretion [2]. The innervation of proximal and distal convoluted tubules, of the thick ascending limb of Henle's loop, as well as of cortical collecting tubules, is well established [26]. Moreover, the additional release of norepinephrine into the renal interstitium could be an effective route for the delivery of this neurotransmitter to its receptors located on the basolateral membrane of renal tubular epithelial cells throughout the entire length of the renal nephron [2].…”

Section: Discussionmentioning

confidence: 99%

Impaired response of the denervated kidney to endothelin receptor blockade in normotensive and spontaneously hypertensive rats

Girchev¹,

Bäcker²,

Markova³

et al. 2004

Kidney International

View full text Add to dashboard Cite

show abstract

“…In large part, changes in renin secretion mediated by ␣-adrenergic activity can be explained by coincident hemodynamic and reabsorptive changes in the kidney, as previously reviewed by Moss et al (68). Any role for calcium, other than secondary to renal vasoconstriction, is not defined.…”

Section: Classic Pathways For Stimulating Reninmentioning

confidence: 93%

The role of calcium in the regulation of renin secretion

Beierwaltes

2010

American Journal of Physiology-Renal Physiology

View full text Add to dashboard Cite

Renin is the enzyme which is the rate-limiting step in the formation of the hormone angiotensin II. Therefore, the regulation of renin secretion is critical in understanding the control of the renin-angiotensin-aldosterone system and its many biological and pathological actions. Renin is synthesized, stored in, and released from the juxtaglomerular (JG) cells of the kidney. While renin secretion is positively regulated by the "second messenger" cAMP, unlike most secretory cells, renin secretion from the JG cell is inversely related to the extracellular and intracellular calcium concentrations. This novel relationship is referred to as the "calcium paradox." This review will address observations made over the past 30 years regarding calcium and the regulation of renin secretion, and focus on recent observations which address this scientific conundrum. These include 1) receptor-mediated pathways for changing intracellular calcium; 2) the discovery of a calcium-inhibitable isoform of adenylyl cyclase associated with renin in the JG cells; 3) calcium-sensing receptors in the JG cells; 4) calcium-calmodulin-mediated signals; 5) the role of phosphodiesterases; and 6) connexins, gap junctions, calcium waves, and the cortical extracellular calcium environment. While cAMP is the dominant second messenger for renin secretion, calcium appears to modulate the integrated activities of the enzymes, which balance cAMP synthesis and degradation. Thus this review concludes that calcium modifies the amplitude of cAMP-mediated renin-signaling pathways. While calcium does not directly control renin secretion, increased calcium inhibits and decreased calcium amplifies cAMP-stimulated renin secretion.

show abstract

Neural Control of Renal Function

Abstract: The sections in this article are: Current Research Historical Perspective Neuroanatomy and Neurophysiology Efferent Renal Innervation Afferent Renal Innervation Renal Adrenergic Receptors General Concepts Prejunctional Renal Receptors … Show more

Cited by 11 publications

References 467 publications

Renal and Cardiovascular Effects of Renal Denervation in Conscious Rats after Adenosine Administration and Nitric Oxide Synthase Inhibition

Renal and Cardiovascular Effects of Renal Denervation in Conscious Rats after Adenosine Administration and Nitric Oxide Synthase Inhibition

Impaired response of the denervated kidney to endothelin receptor blockade in normotensive and spontaneously hypertensive rats

The role of calcium in the regulation of renin secretion

Contact Info

Product

Resources

About