Neural Control of the Avian Heart

Cabot, John B.; Cohen, David H.

doi:10.1016/b978-0-12-119401-7.50013-x

Cited by 10 publications

(4 citation statements)

References 190 publications

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“…Cardiac vagal tone is reportedly high in many birds, with bilateral vagotomy causing a tripling of heart rate in the pigeon and duck. Direct evidence of cardiac vagal tone was obtained from the pigeon, in which the majority of CVPN were reckoned to be active in the unanesthetized bird (108). This observation may now be open to question due to the current debate regarding the central location of CVPN in birds (see sect.…”

Section: F Birdsmentioning

confidence: 99%

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Central Control of the Cardiovascular and Respiratory Systems and Their Interactions in Vertebrates

Taylor

Jordan

Coote

1999

Physiological Reviews

336

278

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This review explores the fundamental neuranatomical and functional bases for integration of the respiratory and cardiovascular systems in vertebrates and traces their evolution through the vertebrate groups, from primarily water-breathing fish and larval amphibians to facultative air-breathers such as lungfish and some adult amphibians and finally obligate air-breathers among the reptiles, birds, and mammals. A comparative account of respiratory rhythm generation leads to consideration of the changing roles in cardiorespiratory integration for central and peripheral chemoreceptors and mechanoreceptors and their central projections. We review evidence of a developing role in the control of cardiorespiratory interactions for the partial relocation from the dorsal motor nucleus of the vagus into the nucleus ambiguus of vagal preganglionic neurons, and in particular those innervating the heart, and for the existence of a functional topography of specific groups of sympathetic preganglionic neurons in the spinal cord. Finally, we consider the mechanisms generating temporal modulation of heart rate, vasomotor tone, and control of the airways in mammals; cardiorespiratory synchrony in fish; and integration of the cardiorespiratory system during intermittent breathing in amphibians, reptiles, and diving birds. Concluding comments suggest areas for further productive research.

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Section: F Birdsmentioning

confidence: 99%

“…Neural control of the avian heart was reviewed by Cabot and Cohen (108). The heart in birds is innervated by branches of the vagus nerve that exert a cholinergic, tonic inhibitory influence on heart rate so that bilateral vagotomy causes a marked tachycardia (628).…”

Section: F Birdsmentioning

confidence: 99%

Central Control of the Cardiovascular and Respiratory Systems and Their Interactions in Vertebrates

Taylor

Jordan

Coote

1999

Physiological Reviews

336

278

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show abstract

“…This finding can be explained by the distribution of cholinergic neurones in the heart. There are more parasympathetic nerve endings in the right atria than in the left atria (Cabot & Cohen, 1980). Since most of the effects of SP are mediated by ACh release, it is not surprising that the effects of SP are higher in right atria than in left.…”

Section: Discussionmentioning

confidence: 96%

Local cardiac effects of substance P: roles of acetylcholine and noradrenaline

Chiao¹,

Caldwell

1995

British J Pharmacology

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1 The local cardiac actions of substance P were examined in isolated perfused hearts and atria of the guinea-pig.2 In both hearts and right atria, substance P caused negative inotropic and chronotropic effects. 3 Atropine (10-6M) or depletion of acetylcholine, by electrical stimulation and hemicholinium-3 perfusion, significantly attenuated the negative inotropic and chronotropic effects of substance P. a-and P-adrenoceptor blockade by nadolol and phentolamine (10-6M each) did not prevent the negative inotropic and chronotropic effects of substance P. This indicates that cholinergic neurones, but not adrenergic neurones, partially mediate the effects of substance P. 4 There was no significant difference in the effects of substance P observed between groups with acetylcholine depletion and with cholinoceptor blockade. This suggests that substance P elicits its effects mainly through release of acetylcholine. 5 These results indicate that substance P has negative inotropic and chronotropic effects in guinea-pig hearts and right atria mediated partly by release of acetylcholine. Substance P also appears to have direct effects on cardiac tissue.

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“…Although these subsidiary themes were of genuine interest to me, they also generated support for the laboratory during the long march to develop the model to the point at which single-cell studies could be undertaken. For example, neural control of the cardiovascular system enabled a successful application to the National Heart, Lung, and Blood Institute at NIH for a Research Career Development Award and, over the years, the laboratory generated a number of publications relating to neural control of the cardiovascular system (e.g., Macdonald and Cohen 1973;Cohen and Cabot 1979;Cabot and Cohen 1980;Cohen and Randall 1984).…”

Section: Developing the Behavioral Modelmentioning

confidence: 99%

David H. Cohen

2016

The History of Neuroscience in Autobiography, Volume 9

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Neural Control of the Avian Heart

Cited by 10 publications

References 190 publications

Central Control of the Cardiovascular and Respiratory Systems and Their Interactions in Vertebrates

Central Control of the Cardiovascular and Respiratory Systems and Their Interactions in Vertebrates

Local cardiac effects of substance P: roles of acetylcholine and noradrenaline

David H. Cohen

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