Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder

Lee, Byeong Taek; Seok, Jeong Ho; Lee, Boung Chul; Cho, Seong Whi; Yoon, Bong June; Lee, Kyoung‐Uk; Chae, Jung Ho; Choi, Ihn Geun; Ham, Byung Joo

doi:10.1016/j.pnpbp.2007.12.009

Cited by 112 publications

(94 citation statements)

References 57 publications

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“…Pain causes increased activity in the nervous system, leading to increased complexity of the individual life system [5][6][7]. And sadness causes reduced activity in the brain and reduced complexity [8][9][10]. This is consistent with the results obtained in this study.…”

Section: Discussionsupporting

confidence: 90%

Inherent Emotional Feature Extraction of Neonatal Cry

Zhao

Meng

2017

Proceedings of the IS4SI 2017 Summit DIGITALISATION FOR a SUSTAINABLE SOCIETY, Gothenburg, Sweden, 12–16 June 2017.

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Abstract:Mining the inherent emotional feature of life is of great significance, and the method to extract the inherent emotional feature with a small number of samples is explored based on neonatal cry in this study. The minimum embedding dimension is taken as the nonlinear feature representing nervous system activity and emotion, and is also analyzed at multiple scales. It is found that the minimum embedding dimension of pain cries is higher than that of sad cries, and has a certain change rule in different frequency bands. The results are consistent with related emotional research of brain nerve activity and the characteristics of the pain cry, and may help in the study of information ecology of the brain in different emotions.

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Section: Discussionsupporting

confidence: 90%

Inherent Emotional Feature Extraction of Neonatal Cry

Zhao

Meng

2017

Proceedings of the IS4SI 2017 Summit DIGITALISATION FOR a SUSTAINABLE SOCIETY, Gothenburg, Sweden, 12–16 June 2017.

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“…In contrast, it has been clearly shown that antidepressant treatment leads to significant changes in cerebral functioning. 45,46 Lee and colleagues 47 demonstrated reduced activation in depressed patients compared with healthy controls in the dorsolateral prefrontal cortex and orbitofrontal cortex, hippocampus and caudate nucleus when sad faces were presented and reduced activity in the orbitofrontal cortex when angry faces were presented. But if only patients receiving an- Scatterplots and correlation coefficients (r) for the association between orbitofrontal cortex volume and cerebral activity of the dorsolateral prefrontal cortex, caudatus, precuneus and supplementary motor area for patients with major depression and healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Orbitofrontal volume reductions during emotion recognition in patients with major depression

Scheuerecker

Meisenzahl

Koutsouleris

et al. 2010

jpn

109

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311Background: Major depressive disorder is associated with both structural and functional alterations in the emotion regulation network of the central nervous system. The relation between structural and functional changes is largely unknown. Therefore, we sought to determine the relation between structural differences and functional alterations during the recognition of emotional facial expressions. Methods: We examined 13 medication-free patients with major depression and 15 healthy controls by use of structural T 1 -weighted high-resolution magnetic resonance imaging (MRI) and functional MRI during 1 session. We set the statistical threshold for the analysis of imaging data to p < 0.001 (uncorrected). Results: As shown by voxel-based morphometry, depressed patients had reductions in orbitofrontal cortex volume and increases in cerebellar volume. Additionally, depressed patients showed increased activity during emotion recognition in the middle frontal cortex, caudate nucleus, precuneus and lingual gyrus. Within this cerebral network, the orbitofrontal volumes were negatively correlated in depressed patients but not in healthy controls with changes in blood oxygen level-dependent signal in the middle frontal gyrus, caudate nucleus, precuneus and supplementary motor area. Limitations: Our results are limited by the relatively small sample size. Conclusions: This combined functional and structural MRI study provides evidence that the orbitofrontal cortex is a key area in major depression and that structural changes result in functional alterations within the emotional circuit. Whether these alterations in the orbitofrontal cortex are also related to persistent emotional dysfunction in remitted mental states and, therefore, are related to the risk of depression needs further exploration.

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“…The fundamental mechanisms underlying the emotional dysregulation of MDD remain unclear ; however, these mechanisms are likely to involve the neural system that subserves emotional processing, including its key components, the prefrontal cortex (PFC) and the amygdala. Convergent studies provide support for abnormalities in the structure and function of the PFC and the amygdala in MDD (Mayberg et al 1999 ;Dougherty et al 2004 ;Johnstone et al 2007 ;Lee et al 2008 ;MacQueen, 2009 ;Frodl et al 2010). Positron emission tomography (PET) studies have shown increased metabolism in the amygdala (Drevets et al 2002) and decreased metabolism in the PFC in MDD (Sackeim et al 1990) ; similarly, functional magnetic resonance imaging (fMRI) studies have shown increased activation in the amygdala (Sheline et al 2001 ;Anand et al 2005a ;Siegle et al 2007) and decreased activation in the PFC in MDD (Siegle et al 2007 ; Lee et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: a resting-state functional magnetic resonance imaging study

et al. 2012

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Tang, Y.; Kong, L.; Womer, F.; Jiang, W.; Cao, Y.; Ren, L.; Wang, J.; Fan, G.; Blumberg, H. P.; Xu, K.; and Wang, F., ,"Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: A resting-state functional magnetic resonance imaging study. " Psychological Medicine.43,9. 1921-1927. (2012 Background. Convergent studies provide support for abnormalities in the structure and functioning of the prefrontal cortex (PFC) and the amygdala, the key components of the neural system that subserves emotional processing in major depressive disorder (MDD). We used resting-state functional magnetic resonance imaging (fMRI) to examine potential amygdala-PFC functional connectivity abnormalities in treatment-naive subjects with MDD.Methods. Resting-state fMRI data were acquired from 28 individuals with MDD and 30 healthy control (HC) subjects. Amygdala-PFC functional connectivity was compared between the MDD and HC groups.Results. Decreased functional connectivity to the left ventral PFC (VPFC) from the left and right amygdala was observed in the MDD group, compared with the HC group (p<0.05, corrected).Conclusions. The treatment-naive subjects with MDD showed decreased functional connectivity from the amygdala to the VPFC, especially to the left VPFC. This suggests that these connections may play an important role in the neuropathophysiology of MDD at its onset.

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Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder

Cited by 112 publications

References 57 publications

Inherent Emotional Feature Extraction of Neonatal Cry

Inherent Emotional Feature Extraction of Neonatal Cry

Orbitofrontal volume reductions during emotion recognition in patients with major depression

Decreased functional connectivity between the amygdala and the left ventral prefrontal cortex in treatment-naive patients with major depressive disorder: a resting-state functional magnetic resonance imaging study

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