Neural Correlates of Emotion Regulation and Adolescent Suicidal Ideation

Miller, Adam Bryant; McLaughlin, Katie A.; Busso, Daniel S.; Brueck, Stephanie; Peverill, Matthew; Sheridan, Margaret A.

doi:10.1016/j.bpsc.2017.08.008

Cited by 55 publications

(59 citation statements)

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“…Functionally, while adult SAs with MDD showed increased cerebellum activation during recall and reimagination of their own suicidal episode [71] and while viewing angry faces, they showed decreased activation while viewing happy faces [47]. Decreased activation was also observed while passively viewing negative emotional pictures in adolescents with a history of SI [72]. Finally, ketamine-induced reductions in SI were associated with increases in rCMRglu including in cerebellum [150].…”

Section: Posterior Structuresmentioning

confidence: 92%

“…Functionally, decreased lateral (and medial) DPFC activation when ten adults with self-reported depression listened to their own narrative of their attempt was reported in a study in which imaging was conducted close to the time of the attempts (1-4 weeks prior [71]). A study of adolescents with a history of SI showing lower right DLPFC activation during passive viewing of negative emotional scenes suggests that DLPFC decreases during processing of negative emotional stimuli might be present early in the course of SI [72]. Higher right DLPFC engagement was observed during regulation of responses to negative emotional scenes in the same adolescents, suggesting the direction of DLPFC differences depends on the specific task requirements (passive viewing vs regulating) [72].…”

Section: Dlpfcmentioning

confidence: 99%

“…A study of adolescents with a history of SI showing lower right DLPFC activation during passive viewing of negative emotional scenes suggests that DLPFC decreases during processing of negative emotional stimuli might be present early in the course of SI [72]. Higher right DLPFC engagement was observed during regulation of responses to negative emotional scenes in the same adolescents, suggesting the direction of DLPFC differences depends on the specific task requirements (passive viewing vs regulating) [72]. Another study in adolescent SAs with MDD suggests that the direction may also relate to the specific emotion, as passive viewing of angry faces, but not happy faces, elicited higher DLPFC responses [73], perhaps due to the high sensitivity to criticism and social rejection previously reported in individuals with STBs [74,75].…”

Section: Dlpfcmentioning

confidence: 99%

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Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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Identifying brain alterations that contribute to suicidal thoughts and behaviors (STBs) are important to develop more targeted and effective strategies to prevent suicide. In the last decade, and especially in the last 5 years, there has been exponential growth in the number of neuroimaging studies reporting structural and functional brain circuitry correlates of STBs. Within this narrative review, we conducted a comprehensive review of neuroimaging studies of STBs published to date and summarize the progress achieved on elucidating neurobiological substrates of STBs, with a focus on converging findings across studies. We review neuroimaging evidence across differing mental disorders for structural, functional, and molecular alterations in association with STBs, which converges particularly in regions of brain systems that subserve emotion and impulse regulation including the ventral prefrontal cortex (VPFC) and dorsal PFC (DPFC), insula and their mesial temporal, striatal and posterior connection sites, as well as in the connections between these brain areas. The reviewed literature suggests that impairments in medial and lateral VPFC regions and their connections may be important in the excessive negative and blunted positive internal states that can stimulate suicidal ideation, and that impairments in a DPFC and inferior frontal gyrus (IFG) system may be important in suicide attempt behaviors. A combination of VPFC and DPFC system disturbances may lead to very high risk circumstances in which suicidal ideation is converted to lethal actions via decreased top-down inhibition of behavior and/or maladaptive, inflexible decision-making and planning. The dorsal anterior cingulate cortex and insula may play important roles in switching between these VPFC and DPFC systems, which may contribute to the transition from suicide thoughts to behaviors. Future neuroimaging research of larger sample sizes, including global efforts, longitudinal designs, and careful consideration of developmental stages, and sex and gender, will facilitate more effectively targeted preventions and interventions to reduce loss of life to suicide.

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Section: Posterior Structuresmentioning

confidence: 92%

Section: Dlpfcmentioning

confidence: 99%

Section: Dlpfcmentioning

confidence: 99%

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Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

et al. 2019

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“…The prevalence of suicide attempts in the United States is 4.1%, while, in Europe, the lifetime prevalence is similar (4.2%; Carli et al, 2014). SI is defined as "thoughts about death, dying, plans for suicide, or desire for death" (Miller et al, 2018;Levi-Belz et al, 2019). The theoretical perspective aims to review the Ventromedial Prefrontal Cortex's role and its association with risk factors, such as anxiety, depression, and social isolation, involved in adolescents experiencing SI thoughts.…”

Section: Introductionmentioning

confidence: 99%

Suicidal Ideation in Adolescence: A Perspective View on the Role of the Ventromedial Prefrontal Cortex

Morese

Longobardi

2020

Front. Psychol.

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Suicide in adolescence is a worldwide issue, and it continues to present a serious problem in terms of its prevention. Among the various aspects of suicide, a very interesting area of research is represented by suicidal ideation. Recently, neuroimagingbased methods have made it possible to study the cognitive processes involved in several social situations and clinical conditions. This theoretical perspective article with an interdisciplinary approach integrates evidence from developmental psychology and social neuroscience with the aim of investigating the role of the brain area responsible for regulating negative emotions during the cognitive processes of suicidal ideation: the ventromedial prefrontal cortex. By highlighting the role of brain areas in the few studies published so far, it is possible to develop perspectives of considerable impact. Studying and understanding the role of brain areas involved in suicidal thoughts in adolescents could facilitate the creation of new perspectives on prevention programs and interventions.

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“…[4][5][6][7][8] Difficulties with emotion regulation are linked to child internalising and externalising problems, [4,5] and to peer rejection, antisocial behaviour, and suicide risk. [6,9,10] These associations are known to persist into later life, where adults with poor self-regulation are more likely to have mental health problems. [7] The effects of poor emotion regulation also translate to the parenting context, where parent emotion regulation difficulties are linked to less supportive parenting practices, [11] and to child behaviour and conduct problems.…”

Section: Introductionmentioning

confidence: 99%

Child and Parent Emotion Study (CAPES)

Westrupp¹,

Youssef²,

Bennett³

et al. 2020

Preprint

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Introduction: Parents shape child emotional competence and mental health via their beliefs about children’s emotions, emotion-coaching parenting, the emotional climate of the family, and by modelling emotion regulation skills. However, studies to-date have had small samples and focussed on mothers of primary-school age children. Further research is needed to elucidate the direction and timing of associations for mothers and fathers/partners across different stages of child development. The Child and Parent Emotion Study (CAPES) aims to examine longitudinal associations between parent emotion socialisation and child emotion regulation and socio-emotional adjustment at four time-points from pregnancy to age 12. CAPES will investigate the moderating role of parent gender, child temperament and gender, and family background. Methods and analysis: CAPES recruited 2,336 current parents of a child 0-9 years and prospective parents (i.e., women or their partners pregnant with their first child) in 2018-2019. Participants will complete a 20-30 minute online survey at four time-points 12 months apart, to be completed in December 2022. Measures include validated parent-report tools of parent emotion socialisation (i.e., parent beliefs, the family emotional climate, emotion coaching, and parent emotion regulation) and age-sensitive measures of child outcomes (i.e., emotion regulation and socio-emotional adjustment). Analyses will use mixed effects regression to simultaneously assess associations over three time-point transitions (i.e., T1 to T2; T2 to T3; T3 to T4), with exposure variables lagged to estimate how past factors predict outcomes 12 months later. Ethics and dissemination: Ethics approval for the four time-points has been obtained for this study. We will disseminate results through conferences and open access publications; and results will also inform the development of a new early childhood parenting intervention. We will invite parent end-users to co-develop our dissemination strategy, and discuss the interpretation of key findings prior to publication.

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Neural Correlates of Emotion Regulation and Adolescent Suicidal Ideation

Cited by 55 publications

References 55 publications

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Imaging suicidal thoughts and behaviors: a comprehensive review of 2 decades of neuroimaging studies

Suicidal Ideation in Adolescence: A Perspective View on the Role of the Ventromedial Prefrontal Cortex

Child and Parent Emotion Study (CAPES)

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