Neural correlates of fear conditioning are associated with treatment-outcomes to behavioral exposure in spider phobia – Evidence from magnetoencephalography

Roesmann, Kati; Toelle, Julius; Leehr, Elisabeth J.; Wessing, Ida; Böhnlein, Joscha; Seeger, Fabian; Schwarzmeier, Hanna; Siminski, Niklas; Dannlowski, Udo; Lueken, Ulrike; Klucken, Tim; Straube, Thomas; Junghöfer, Markus

doi:10.1016/j.nicl.2022.103046

Cited by 6 publications

(7 citation statements)

References 70 publications

(132 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recent work with adults using MEG found a link between early (<300 ms) and late (>300 ms) brain signals during threat conditioning and treatment outcomes. Specifically, treatment non‐responders showed enhanced differential (CS+/CS−) activation in dlPFC regions during early to mid‐latencies and enhanced differential activation in occipito‐parietal regions during late latency following stimulus onset (Roesmann, Toelle, et al., 2022). In another study, during the generalization test, treatment non‐responders showed enhanced differentiation between morphs in dorso‐ and ventro‐lateral prefrontal clusters during late latency compared to responders (Roesmann, Leehr, et al., 2022).…”

Section: Discussionmentioning

confidence: 99%

Enhanced late positive potential to conditioned threat cue during delayed extinction in anxious youth

Klein,

Shner‐Livne,

Danon‐Kraun

et al. 2023

Child Psychology Psychiatry

View full text Add to dashboard Cite

BackgroundDeficits in threat learning relate to anxiety symptoms. Since several anxiety disorders arise in adolescence, impaired adolescent threat learning could contribute to adolescent changes in risk for anxiety. This study compared threat learning among anxious and non‐anxious youth using self‐reports, peripheral psychophysiology measures, and event‐related potentials. Because exposure therapy, the first‐line treatment for anxiety disorders, is largely based on principles of extinction learning, the study also examined the link between extinction learning and treatment outcomes among anxious youth.MethodsClinically anxious (n = 28) and non‐anxious (n = 33) youth completed differential threat acquisition and immediate extinction. They returned to the lab a week later to complete a threat generalization test and a delayed extinction task. Following these two experimental visits, anxious youth received exposure therapy for 12 weeks.ResultsAnxious as compared to non‐anxious youth demonstrated elevated cognitive and physiological responses across acquisition and immediate extinction learning, as well as greater threat generalization. In addition, anxious youth showed enhanced late positive potential response to the conditioned threat cue compared to the safety cue during delayed extinction. Finally, aberrant neural response during delayed extinction was associated with poorer treatment outcomes.ConclusionsThe study emphasizes differences between anxious and non‐anxious youth in threat learning processes and provides preliminary support for a link between neural processing during delayed extinction and exposure‐based treatment outcome in pediatric anxiety.

show abstract

Section: Discussionmentioning

confidence: 99%

Enhanced late positive potential to conditioned threat cue during delayed extinction in anxious youth

Klein,

Shner‐Livne,

Danon‐Kraun

et al. 2023

Child Psychology Psychiatry

View full text Add to dashboard Cite

show abstract

“…The rejection of artifact-contaminated trials and the interpolation of artifact-contaminated sensors relies on the calculation of statistical parameters for the absolute measured magnetic field amplitudes over time, their standard deviation over time, as well as on the determination of boundaries for each parameter based on their distribution across trials. If the goodness of test topography interpolations based on the residual sensor configuration within a given trial did not reach an a-priori defined minimum criterion (k = 0.01; Roesmann et al, 2022b , Roesmann et al, 2022c , Roesmann et al, 2020 ; identical for each subject and run) the respective trial was rejected. If more than 30% of the trials in any run of either the Baseline or the Test phase did not meet this criterion (e.g.…”

Section: Methodsmentioning

confidence: 99%

“…Thus, a linear contrast with the factor STIMULUS TYPE (CS-&GS1, GS1&2, GS2&3, GS3&4, GS4&5, GS5&6, GS6&7, GS7&CS+) was calculated for each time point and dipole. Second, to identify clusters displaying group differences in linear gradients a STIMULUS TYPE x GROUP interaction analysis with an orthogonal linear contrast for adults vs. adolescents ( Greenberg et al, 2013 , Roesmann et al, 2022b , Roesmann et al, 2022c ) was calculated for each time point and dipole. These computations resulted in matrices of T-values for each time point and dipole.…”

Section: Methodsmentioning

confidence: 99%

Developmental aspects of fear generalization – A MEG study on neurocognitive correlates in adolescents versus adults

Roesmann

Wessing

Kraß

et al. 2022

Developmental Cognitive Neuroscience

Self Cite

View full text Add to dashboard Cite

“…The existence of gradual challenges, where each task is presented only when the user feels comfortable with the level of challenge offered in the previous task, promotes feelings of competence and contributes to a minimum ludic immersion potential. All studies classified as having low ludic immersion potential had some form of difficulty variation, either adaptively based on individual anxiety levels [81] or via predefined tasks and environments with different difficulty levels [60,[66][67][68][69][70][71][72][73][74][75][76][77][78][79][80]82].…”

Section: Low Potential For Ludic Immersionmentioning

confidence: 99%

“…The possibility of moving in the VRE with 6DOF alone is generally sufficient to provide a moderate sense of spatial immersion. A majority of the studies allowed a navigation with 6DOF, encompassing three degrees of rotation and three degrees of translation [68][69][70][71]73,74,[76][77][78][79][80]83,84,87].…”

Section: Moderate Potential For Spatial Immersionmentioning

confidence: 99%

Ludic and Narrative Immersion in Virtual Reality Exposure Therapy to Animal Phobias: A Systematic Literature Review

Martins,

Vairinhos

2023

Virtual Worlds

View full text Add to dashboard Cite

In the context of therapeutic exposure to phobias, virtual reality (VR) offers innovative ways to motivate patients to confront their fears, an opportunity not feasible in traditional non-digital settings. This systematic literature review explores the utilization of narratives and digital games in this context, focusing on identifying the most common ludic and narrative immersion features employed in studies dedicated to animal phobias. Via a search on the Scopus and Web of Science scientific databases, twenty-nine studies were selected for in-depth analysis. The primary objective was to evaluate the presence of ludic and narrative elements in each study to understand their immersive potential across both dimensions. Findings suggest that ludic elements are more commonly used than narrative elements, which are notably scarce, and the exploration of the emotional dimension of narrative immersion is limited. An essential takeaway is that features fostering narrative immersion are invariably linked to the ludic dimension, often functioning as secondary components. This study provides a guiding framework for developing therapeutic interventions in VR, emphasizing the incorporation of ludic and narrative aspects. Additionally, it identifies untapped research opportunities, particularly the integration of autonomous narratives that are less reliant on ludic elements.

show abstract

Neural correlates of fear conditioning are associated with treatment-outcomes to behavioral exposure in spider phobia – Evidence from magnetoencephalography

Cited by 6 publications

References 70 publications

Enhanced late positive potential to conditioned threat cue during delayed extinction in anxious youth

Enhanced late positive potential to conditioned threat cue during delayed extinction in anxious youth

Developmental aspects of fear generalization – A MEG study on neurocognitive correlates in adolescents versus adults

Ludic and Narrative Immersion in Virtual Reality Exposure Therapy to Animal Phobias: A Systematic Literature Review

Contact Info

Product

Resources

About