Neural correlates of intentional and stimulus-driven inhibition: a comparison

Schel, Margot A.; Kühn, Simone; Braß, Marcel; Haggard, Patrick; Ridderinkhof, K. Richard; Crone, Eveline A.

doi:10.3389/fnhum.2014.00027

Cited by 66 publications

(31 citation statements)

References 37 publications

(73 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the early studies using this method, facilitation was observed for muscles associated with the forthcoming response and inhibition was observed for muscles associated with nonselected responses (Chen & Hallett, 1999; Duque, et al, 2005; Leocani, et al., 2000). These findings led to the hypothesis that inhibitory mechanisms are recruited during response selection to suppress activity in muscles associated with actions that are not selected (Koch, et al, 2006; Schel, et al, 2014; van den Wildenberg, et al, 2010), a process we have termed competition resolution (CR) (Duque, et al, 2010). …”

Section: Discussionmentioning

confidence: 99%

Dissociating the influence of response selection and task anticipation on corticospinal suppression during response preparation

et al. 2014

View full text Add to dashboard Cite

Motor behavior requires selecting between potential actions. The role of inhibition in response selection has frequently been examined in tasks in which participants are engaged in some advance preparation prior to the presentation of an imperative signal. Under such conditions, inhibition could be related to processes associated with response selection, or to more general inhibitory processes that are engaged in high states of anticipation. In Experiment 1, we manipulated the degree of anticipatory preparation. Participants performed a choice reaction time task that required choosing between a movement of the left or right index finger, and used transcranial magnetic stimulation (TMS) to elicit motor evoked potentials (MEPs) in the left hand agonist. In high anticipation blocks, a non-informative cue (e.g., fixation marker) preceded the imperative; in low anticipation blocks, there was no cue and participants were required to divide their attention between two tasks to further reduce anticipation. MEPs were substantially reduced before the imperative signal in high anticipation blocks. In contrast, in low anticipation blocks, MEPs remained unchanged before the imperative signal but showed a marked suppression right after the onset of the imperative. This effect occurred regardless of whether the imperative had signaled a left or right hand response. After this initial inhibition, left MEPs increased when the left hand was selected and remained suppressed when the right hand was selected. We obtained similar results in Experiment 2 except that the persistent left MEP suppression when the left hand was not selected was attenuated when the alternative response involved a non-homologous effector (right foot). These results indicate that, even in the absence of an anticipatory period, inhibitory mechanisms are engaged during response selection, possibly to prevent the occurrence of premature and inappropriate responses during a competitive selection process.

show abstract

Section: Discussionmentioning

confidence: 99%

Dissociating the influence of response selection and task anticipation on corticospinal suppression during response preparation

et al. 2014

View full text Add to dashboard Cite

show abstract

“…More generally, throughout development, people have been instructed not to do certain things many times; eventually, they will learn some of this, and this could influence decision-making in a direct, automatic fashion. Sequential dependencies, which can influence the 'whether' decision (Schel et al 2014), may also be (partly) associatively mediated. After executing an action a couple of times, subjects may be more (or less) likely to execute the action again.…”

Section: Implications For Intentional Inhibitionmentioning

confidence: 99%

The inhibitory control reflex

et al. 2014

View full text Add to dashboard Cite

Response inhibition is typically considered a hallmark of deliberate executive control. In this article, we review work showing that response inhibition can also become a 'prepared reflex', readily triggered by information in the environment, or after sufficient training, or a 'learned reflex' triggered by the retrieval of previously acquired associations between stimuli and stopping. We present new results indicating that people can learn various associations, which influence performance in different ways. To account for previous findings and our new results, we present a novel architecture that integrates theories of associative learning, Pavlovian conditioning, and executive response inhibition. Finally, we discuss why this work is also relevant for the study of 'intentional inhibition'.

show abstract

“…The authors suggest that the expression of abnormal and excessive movement may in part reflect a failure of inhibition. Motor inhibition and intention have been conceptualized as two sides of the same coin, with nonconscious motor inhibition 37 and intentional and cued motor inhibition [38][39][40] implicating the supplementary motor complex (the same region also implicated in motor intention). However, a study using a motor inhibitory go/no-go functional magnetic resonance imaging (fMRI) task did not support either abnormalities in intention or inhibition.…”

mentioning

confidence: 99%

Functional Neuroanatomy and Neurophysiology of Functional Neurological Disorders (Conversion Disorder)

Voon¹,

Cavanna²,

Coburn³

et al. 2016

JNP

134

View full text Add to dashboard Cite

Much is known regarding the physical characteristics, comorbid symptoms, psychological makeup, and neuropsychological performance of patients with functional neurological disorders (FNDs)/conversion disorders. Gross neurostructural deficits do not account for the patients' deficits or symptoms. This review describes the literature focusing on potential neurobiological (i.e. functional neuroanatomic/neurophysiological) findings among individuals with FND, examining neuroimaging and neurophysiological studies of patients with the various forms of motor and sensory FND. In summary, neural networks and neurophysiologic mechanisms may mediate "functional" symptoms, reflecting neurobiological and intrapsychic processes. J Neuropsychiatry Clin Neurosci 2016; 28:168-190; doi: 10.1176/appi.neuropsych.14090217 Functional neurological disorders (FNDs; or psychogenic neurological symptoms), also known as conversion disorder, are a classic neuropsychiatric disorder, existing in the border between neurology and psychiatry. Unexplained neurological symptoms are common, occurring in up to one-third of patients in neurological outpatient clinics.1 Relative to disorders such as Parkinson's disease, FND is associated with similar levels of disability and physical quality of life with poorer mental health quality of life. 2 The prognosis is poor, with a recent reviewshowing that up to 40% of patients with FND report similar or worse outcomes at 7-year follow-up. 3 Given the frequency, consequences, prognosis, and burden, FND has been called a "crisis for neurology." 4 Despite this, FND is poorly understood. In the last decade, an increasing number of studies have focused on underlying neurobiological mechanisms. FND is defined in DSM-5 as the presence of one or more symptoms of altered voluntary or sensory function, with clinical findings providing evidence of incompatibility between the symptom and recognized neurological or medical conditions.5 The DSM-5 diagnosis differs from that of the DSM-IV diagnosis of conversion disorder by adding the criterion of incorporating physical diagnostic features and by relegating to the accompanying text the criteria requiring (a) an association with psychological stressors and (b) the exclusion of malingering or factitious disorder to make the diagnosis. DSM-5 FND diagnosis criteria now allow for potential greater interrater reliability, making them appropriate for research studies and greater compatibility with specialtyspecific diagnoses including psychogenic movement disorder (PMD) and psychogenic nonepileptic seizures (PNES). 6The putative biopsychosocial mechanisms underlying FND are complex and have been extensively reviewed.7 Our review focuses on the physiological mechanisms that may underlie FND and does not specifically focus on the extensive literature on the antecedents of early childhood experiences and temperament (Figure 1). At the outset, regarding the proposed model, we acknowledge that predisposing factors for functional neurological symptoms are not limited to genetics, te...

show abstract

Neural correlates of intentional and stimulus-driven inhibition: a comparison

Cited by 66 publications

References 37 publications

Dissociating the influence of response selection and task anticipation on corticospinal suppression during response preparation

Dissociating the influence of response selection and task anticipation on corticospinal suppression during response preparation

The inhibitory control reflex

Functional Neuroanatomy and Neurophysiology of Functional Neurological Disorders (Conversion Disorder)

Contact Info

Product

Resources

About