Neural correlates of negative emotion processing in subthreshold depression

Zhang, Shu; Zhang, Yuan; Ma, Wenhao; Qi, Zhangzhang; Wang, Ying; Tao, Qian

doi:10.1093/scan/nsac003

Cited by 12 publications

(7 citation statements)

References 56 publications

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“…A recent rs-fMRI study showed reduced FC between the VTA and SFG and supplementary motor area in MDD (Nakamura et al, 2020). Our previous task-based fMRI study found reduced SFG and middle frontal gyrus activations during negative emotion processing in adolescents with subthreshold depression (Zhang et al, 2022). Moreover, deep brain stimulation to the VTA and the medial forebrain bundle can improve the depressive symptoms in treatment-resistant MDD.…”

Section: Discussionmentioning

confidence: 96%

Increased functional connectivity between the midbrain and frontal cortex following bright light therapy in subthreshold depression: A randomized clinical trial.

Chen,

Yang

et al. 2024

American Psychologist

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The underlying mechanisms of bright light therapy (BLT) in the prevention of individuals with subthreshold depression symptoms are yet to be elucidated. The goal of the study was to assess the correlation between midbrain monoamine-producing nuclei treatment-related functional connectivity (FC) changes and depressive symptom improvements in subthreshold depression. This double-blind, randomized, placebo-controlled clinical trial was conducted between March 2020 and June 2022. A total of 74 young adults with subthreshold depression were randomly assigned to receive 8-week BLT (N = 38) or placebo (N = 36). Depression severity was measured using the Hamilton Depression Rating Scale (HDRS). The participants underwent resting-state functional magnetic resonance imaging at baseline and after treatment. The dorsal raphe nucleus (DRN), ventral tegmental area (VTA), and habenula seed-based whole-brain FC were analyzed. A multivariate regression model examined whether baseline brain FC was associated with changes in scores on HDRS during BLT treatment. BLT group displayed significantly decreased HDRS scores from pre-to posttreatment compared to the placebo group. BLT increased the FC between the DRN and medial prefrontal cortex (mPFC) and between the left VTA and right superior frontal gyrus (SFG). Altered VTA-SFG connectivity was associated with HDRS changes in the BLT group. Moreover, the baseline FC between DRN and mPFC could predict HDRS changes in BLT. These results suggested that BLT improves depressive symptoms and increases midbrain monoamine-producing nuclei and frontal cortex connectivity in subthreshold depression, which raises the possibility that pretreatment FC of DRN-mPFC could be used as a biomarker for improved BLT treatment in depression. Public Significance StatementBLT may improve the depressive symptoms of nonseasonal subthreshold depression by increasing the connectivity between the midbrain and frontal cortex. The pretreatment FC of DRN-mPFC could be used as a biomarker for improved BLT treatment in depression.

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Section: Discussionmentioning

confidence: 96%

Increased functional connectivity between the midbrain and frontal cortex following bright light therapy in subthreshold depression: A randomized clinical trial.

Chen,

Yang

et al. 2024

American Psychologist

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“…MFG is a part of the dorsolateral prefrontal cortex, which is involved in cognitive control and emotion processing ( 96 ). Zhang et al ( 97 ) found that the MFG was responsible for aberrant negative emotion processing. The precentral gyrus is a crucial part of dorsal medial prefrontal cortex (dmPFC), which plays a critical role in the regulation of social cognition ( 98 ).…”

Section: Discussionmentioning

confidence: 99%

The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies

Gou

Guo

et al. 2023

Front. Psychiatry

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BackgroundDepression is generally accompanied by a disturbed conscious processing of emotion, which manifests as a negative bias to facial/voice emotion information and a decreased accuracy in emotion recognition tasks. Several studies have proved that abnormal brain activation was responsible for the deficit function of conscious emotion recognition in depression. However, the altered brain activation related to the conscious processing of emotion in depression was incongruent among studies. Therefore, we conducted an activation likelihood estimation (ALE) analysis to better understand the underlying neurophysiological mechanism of conscious processing of emotion in depression.MethodElectronic databases were searched using the search terms “depression,” “emotion recognition,” and “neuroimaging” from inceptions to April 10th, 2023. We retrieved trials which explored the neuro-responses of depressive patients to explicit emotion recognition tasks. Two investigators independently performed literature selection, data extraction, and risk of bias assessment. The spatial consistency of brain activation in conscious facial expressions recognition was calculated using ALE. The robustness of the results was examined by Jackknife sensitivity analysis.ResultsWe retrieved 11,365 articles in total, 28 of which were included. In the overall analysis, we found increased activity in the middle temporal gyrus, superior temporal gyrus, parahippocampal gyrus, and cuneus, and decreased activity in the superior temporal gyrus, inferior parietal lobule, insula, and superior frontal gyrus. In response to positive stimuli, depressive patients showed hyperactivity in the medial frontal gyrus, middle temporal gyrus, and insula (uncorrected p < 0.001). When receiving negative stimuli, a higher activation was found in the precentral gyrus, middle frontal gyrus, precuneus, and superior temporal gyrus (uncorrected p < 0.001).ConclusionAmong depressive patients, a broad spectrum of brain areas was involved in a deficit of conscious emotion processing. The activation of brain regions was different in response to positive or negative stimuli. Due to potential clinical heterogeneity, the findings should be treated with caution.Systematic review registrationhttps://inplasy.com/inplasy-2022-11-0057/, identifier: 2022110057.

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“…The Beck Depression Inventory (BDI) (59) has been employed to measure the depressive level (60)(61)(62)(63)(64). Two depressive states were identified with the most commonly used cutoff BDI = 14 (BDI < 14, without depression; BDI ≥ 14, with depression) (65).…”

Section: Behavioral Data Acquisitionmentioning

confidence: 99%

Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk

et al. 2022

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BackgroundCircadian rhythm was involved in the pathogenesis of depression. The detection of circadian genes and white matter (WM) integrity achieved increasing focus for early prediction and diagnosis of major depressive disorder (MDD). This study aimed to explore the effects of PER1 gene polymorphisms (rs7221412), one of the key circadian genes, on the association between depressive level and WM microstructural integrity.Materials and methodsDiffusion tensor imaging scanning and depression assessment (Beck Depression Inventory, BDI) were performed in 77 healthy college students. Participants also underwent PER1 polymorphism detection and were divided into the AG group and AA group. The effects of PER1 genotypes on the association between the WM characteristics and BDI were analyzed using tract-based spatial statistics method.ResultsCompared with homozygous form of PER1 gene (AA), more individuals with risk allele G of PER1 gene (AG) were in depression state with BDI cutoff of 14 (χ2 = 7.37, uncorrected p = 0.007). At the level of brain imaging, the WM integrity in corpus callosum, internal capsule, corona radiata and fornix was poorer in AG group compared with AA group. Furthermore, significant interaction effects of genotype × BDI on WM characteristics were observed in several emotion-related WM tracts. To be specific, the significant relationships between BDI and WM characteristics in corpus callosum, internal capsule, corona radiata, fornix, external capsule and sagittal stratum were only found in AG group, but not in AA group.ConclusionOur findings suggested that the PER1 genotypes and emotion-related WM microstructure may provide more effective measures of depression risk at an early phase.

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Neural correlates of negative emotion processing in subthreshold depression

Cited by 12 publications

References 56 publications

Increased functional connectivity between the midbrain and frontal cortex following bright light therapy in subthreshold depression: A randomized clinical trial.

Increased functional connectivity between the midbrain and frontal cortex following bright light therapy in subthreshold depression: A randomized clinical trial.

The conscious processing of emotion in depression disorder: a meta-analysis of neuroimaging studies

Per1 gene polymorphisms influence the relationship between brain white matter microstructure and depression risk

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