Neural Correlates of Negative Emotionality in Borderline Personality Disorder: An Activation-Likelihood-Estimation Meta-Analysis

Ruocco, Anthony C.; Amirthavasagam, Sathya; Choi-Kain, Lois W.; McMain, Shelley

doi:10.1016/j.biopsych.2012.07.014

Cited by 200 publications

(180 citation statements)

References 65 publications

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“…Conversely, previous imaging studies on affective processing generally reported reduced/blunted medial prefrontal cortex/anterior cingulate activation (e.g., Ruocco et al, 2010). Together these findings suggest that medial prefrontal 12 cortex/anterior cingulate hyperactivity at rest in BPD may reflect a dysfunction of frontolimbic circuitry, which then translates into a reduced ability to further activate these prefrontal regions during the performance of emotion processing tasks, and into the subsequent failure to effectively modulate the associated limbic hyperactivity (Ruocco et al, 2013;; Schulze et al, 2016).…”

Section: Discussionmentioning

confidence: 91%

“…Recent meta-analyses on disturbed emotion processing in BPD reported a consistent pattern of altered function and structure in cortical regions, including prefrontal cortex (PFC), and temporal cortex, along with limbic regions, i.e., amygdala and insula (Ruocco et al, 2013;; Schulze et al, 2016). These findings suggest that fronto-limbic dysfunction (i.e., reduced fronto-cingulate activity leading to limbic hyperactivity) could underlie affective dysregulation in BPD (Ruocco et al, 2013). Although convergent to a certain extent, the results of the functional imaging studies carried out for this disorder are heterogeneous.…”

Section: Introductionmentioning

confidence: 99%

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Mapping the brain correlates of borderline personality disorder: A functional neuroimaging meta-analysis of resting state studies

Visintin

Panfilis

Amore

et al. 2016

Journal of Affective Disorders

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To investigate the neural activity at rest in BPD, we conducted a set of meta-analyses of brain imaging studies performed at rest. A total of seven functional imaging studies (152 patients with BPD and 147 control subjects) were combined using whole-brain Signed Differential Mapping meta-analyses. Furthermore, two conjunction meta-analyses of neural activity at rest were also performed: with neural activity changes during emotional processing and with structural differences, respectively. We found altered neural activity in the regions of the default mode network (DMN) in BPD. Within the regions of the core DMN, patients with BPD showed greater activity in the anterior as well as in the posterior midline hubs relative to controls. Conversely, in the regions of the dorsal DMN they showed reduced activity compared to controls in the right lateral temporal complex and in bilateral orbitofrontal cortex. Increased activity in the precuneus was observed both at rest and during emotional processing. Reduced neural activity at rest in lateral temporal complex was associated with smaller volume of this area.Altered activity in the regions of the midline core as well as of the dorsal subsystem of the DMN may reflect difficulties with interpersonal and affective regulation in BPD. These findings suggest that changes in spontaneous neural activity could underlie core symptoms in BPD.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Mapping the brain correlates of borderline personality disorder: A functional neuroimaging meta-analysis of resting state studies

Visintin

Panfilis

Amore

et al. 2016

Journal of Affective Disorders

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“…The first portion of the study investigated whether a dysfunction in connectivity during ToM processing could be found between emotional network, in particular the anterior cingulate cortex (ACC), and ToM regions in BPD patients compared with healthy controls. The ACC was chosen as the seed region as it is known to be involved in emotion processing, empathy, and cognition (Vollm et al, 2006;Bush et al, 2000;Ruocco et al, 2013), with previous studies observing divergent neural dynamics in the ACC of BPD patients compared with healthy controls (Dziobek et al, 2011;Ruocco et al, 2013). Moreover, the ACC has an important role in the integration of neuronal circuitry for affect regulation.…”

Section: Introductionmentioning

confidence: 99%

Dysregulation between emotion and theory of mind networks in borderline personality disorder

O’Neill

D'Souza

Samson

et al. 2015

Psychiatry Research: Neuroimaging

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a b s t r a c tIndividuals with borderline personality disorder (BPD) commonly display deficits in emotion regulation, but findings in the area of social cognitive (e.g., theory of mind, ToM) capacities have been heterogeneous. The aims of the current study were to investigate differences between patients with BPD and controls in functional connectivity (1) between the emotion and ToM network and (2) in the default mode network (DMN). Functional magnetic resonance imaging was used to investigate 19 healthy controls and 17 patients with BPD at rest and during ToM processing. Functional coupling was analysed. Significantly decreased functional connectivity was found for patients compared with controls between anterior cingulate cortex and three brain areas involved in ToM processes: the left superior temporal lobe, right supramarginal/inferior parietal lobes, and right middle cingulate cortex. Increased functional connectivity was found in patients compared with controls between the precuneus as the DMN seed and the left inferior frontal lobe, left precentral/middle frontal, and left middle occipital/ superior parietal lobes during rest. Reduced functional coupling between the emotional and the ToM network during ToM processing is in line with emotion-regulation dysfunctions in BPD. The increased connectivity between precuneus and frontal regions during rest might be related to extensive processing of internal thoughts and self-referential information in BPD.

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“…The medial frontal cortex, implicated in cognitive control and regulation of emotions (8), has also been a target of BPD studies, and although it has not been reported to be significant in whole-brain morphometric comparisons, it has been found to be abnormal in studies of function (9)(10)(11)(12). The medial frontal cortex has extensive connections with the medial temporal cortex (including the amygdala and hippocampus) ensuring the cognitive-emotional control of behavior (13).…”

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confidence: 99%

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

Salvador

Vega

Pascual

et al. 2016

Biological Psychiatry

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BACKGROUND: The psychological profile of patients with borderline personality disorder (BPD), with impulsivity and emotional dysregulation as core symptoms, has guided the search for abnormalities in specific brain areas such as the hippocampal-amygdala complex and the frontomedial cortex. However, whole-brain imaging studies so far have delivered highly heterogeneous results involving different brain locations. METHODS: Functional resting-state and diffusion magnetic resonance imaging data were acquired in patients with BPD and in an equal number of matched control subjects (n 5 60 for resting and n 5 43 for diffusion). While mean diffusivity and fractional anisotropy brain images were generated from diffusion data, amplitude of low-frequency fluctuations and global brain connectivity images were used for the first time to evaluate BPD-related brain abnormalities from resting functional acquisitions. RESULTS: Whole-brain analyses using a p 5 .05 corrected threshold showed a convergence of alterations in BPD patients in genual and perigenual structures, with frontal white matter fractional anisotropy abnormalities partially encircling areas of increased mean diffusivity and global brain connectivity. Additionally, a cluster of enlarged amplitude of low-frequency fluctuations (high resting activity) was found involving part of the left hippocampus and amygdala. In turn, this cluster showed increased resting functional connectivity with the anterior cingulate. CONCLUSIONS: With a multimodal approach and without using a priori selected regions, we prove that structural and functional abnormality in BPD involves both temporolimbic and frontomedial structures as well as their connectivity. These structures have been previously related to behavioral and clinical symptoms in patients with BPD.

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Neural Correlates of Negative Emotionality in Borderline Personality Disorder: An Activation-Likelihood-Estimation Meta-Analysis

Cited by 200 publications

References 65 publications

Mapping the brain correlates of borderline personality disorder: A functional neuroimaging meta-analysis of resting state studies

Mapping the brain correlates of borderline personality disorder: A functional neuroimaging meta-analysis of resting state studies

Dysregulation between emotion and theory of mind networks in borderline personality disorder

Converging Medial Frontal Resting State and Diffusion-Based Abnormalities in Borderline Personality Disorder

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