Neural correlates of performance on the different scoring systems of the clock drawing test

Matsuoka, Teruyuki; Narumoto, Jin; Shibata, Keisuke; Okamura, Aiko; Nakamura, Kaeko; Nakamae, Takashi; Yamada, Kazuo; Fukui, Kenji

doi:10.1016/j.neulet.2010.10.069

Cited by 32 publications

(32 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These group differences were observed when clocks were scored according to the Rouleau scoring system [41], but were not observed with other methods, reflecting the sensitivity of this system to spatial arrangements among clock features. This finding accords with those of Lee and colleagues [44] and Matsuoka and colleagues [45] in Alzheimer’s disease, who reported that Rouleau scores correlated more strongly than did other-system scores with right-parietal structure (i.e. grey matter volume) and function (i.e.…”

Section: Discussionsupporting

confidence: 92%

Side and Type of Initial Motor Symptom Influences Visuospatial Functioning in Parkinson's Disease

Seichepine

Neargarder

Davidsdottir

et al. 2015

Journal of Parkinson's Disease

View full text Add to dashboard Cite

Background/Objectives Visuospatial problems are common in Parkinson’s disease (PD) and likely stem from dysfunction in dopaminergic pathways and consequent disruption of cortical functioning. Characterizing the motor symptoms at disease onset provides a method of observing how dysfunction in these pathways influences visuospatial cognition. We examined two types of motor characteristics: body side (left or right) and type of initial symptom (tremor or symptom other than tremor). Methods 31 non-demented patients with PD, 16 with left-side onset (LPD) and 15 with right-side onset (RPD), as well as 17 healthy control participants (HC). The PD group was also divided by type of initial motor symptom, 15 having tremor as the initial symptom and 16 having an initial symptom other than tremor. Visuospatial function was assessed with the Clock Drawing Test. Results Of the four Clock Drawing scoring methods used, the Rouleau method showed sensitivity to subgroup differences. As predicted, the LPD and non-tremor subgroups, but not the other subgroups, performed more poorly than the HC group. Conclusion The findings provide further evidence for differences in cognition between these subtypes of PD and highlight the importance of considering disease subtypes when examining cognition.

show abstract

Section: Discussionsupporting

confidence: 92%

Side and Type of Initial Motor Symptom Influences Visuospatial Functioning in Parkinson's Disease

Seichepine

Neargarder

Davidsdottir

et al. 2015

Journal of Parkinson's Disease

View full text Add to dashboard Cite

show abstract

“…For example, anchorers compared to non-anchorers had higher local efficiency for the left medial OFC, the right rostral ACC and the right SFG as well as the left temporal gyrus that includes Heschl's gyrus. In general terms, several of these regions were hypothesized to be involved in CDT performance and graphomotor organization more specifically based on previous research in normal and pathological aging (Ino, et al, 2003; Lee, et al, 2008; Matsuoka, et al, 2011; Thomann, Toro, Dos Santos, Essig, & Schroder, 2008; Tranel, et al, 2008). We did not, however, find support for parietal involvement in anchoring behavior; this may be due, in part, to the fact that our local efficiency results may represent a relative advantage for anchorers with respect to the connectivity of neurocircuits responsible for the activation, control, and regulation of visually guided motor acts (Izquierdo, Suda, & Murray, 2004; Koechlin, Ody, & Kouneiher, 2003).…”

Section: 0 Conclusionmentioning

confidence: 99%

“…For example, evidence suggests the CDT requires executive functioning during the Command condition (Cohen, et al, 2014; Cosentino, et al, 2004) when participants must initiate, unassisted, CDT task demands. Likewise, a larger brain network including prefrontal as well as right parietal and bilateral temporal regions is thought to be involved in Command condition performance compared to Copy and/or ‘pre-drawn’ CDT trials (Matsuoka, et al, 2011). Thus, spontaneous graphomotor organization during the CDT Command condition, e.g., deliberately placing the 12, 6, 3, and/or 9 to ensure adequate spacing of all numbers, may promote executive functioning in the form of greater efficiency during the task.…”

Section: 0 Introductionmentioning

confidence: 99%

“…We further hypothesize that these same individuals will display better executive functioning using independent test measures when compared to ‘non-anchorers’. Given that prefrontal, temporal and parietal regions have been implicated in CDT performance including the organization of spatial information such as the layout of numbers (Ino, Asada, Ito, Kimura, & Fukuyama, 2003; Lee, et al, 2008; Matsuoka, et al, 2011; Parks, et al, 2010; Samton, et al, 2005; Tranel, et al, 2008), we hypothesize that individuals who organize their CDT output (versus those who do not) will also show more efficient neural networks associated with these brain regions.…”

Section: 0 Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cognitive and connectome properties detectable through individual differences in graphomotor organization

et al. 2016

View full text Add to dashboard Cite

We investigated whether graphomotor organization during a digitized Clock Drawing Test (dCDT) would be associated with cognitive and/or brain structural differences detected with a tractography-derived structural connectome of the brain. 72 non-demented/non-depressed adults were categorized based on whether or not they used ‘anchor’ digits (i.e., 12,3,6,9) before any other digits while completing dCDT instructions to “draw the face of a clock with all the numbers and set the hands to 10 after 11”. ‘Anchorers’ were compared to ‘non-anchorers’ across dCDT, additional cognitive measures and connectome-based metrics. In the context of grossly intact clock drawings, anchorers required fewer strokes to complete the dCDT and outperformed non-anchorers on executive functioning and learning/memory/recognition tasks. Anchorers had higher local efficiency for the left medial orbitofrontal and transverse temporal cortices as well as the right rostral anterior cingulate and superior frontal gyrus versus non-anchorers suggesting better regional integration within local networks involving these regions; select aspects of which correlated with cognition. Results also revealed that anchorers’ exhibited a higher degree of modular integration among heteromodal regions of the ventral visual processing stream versus non-anchorers. Thus, an easily observable graphomotor distinction was associated with 1) better performance in specific cognitive domains, 2) higher local efficiency suggesting better regional integration, and 3) more sophisticated modular integration involving the ventral (‘what’) visuospatial processing stream. Taken together, these results enhance our knowledge of the brain-behavior relationships underlying unprompted graphomotor organization during dCDT.

show abstract

“…PD-patients with a flawless CDT-performance did not show this association (see Figure 2). The neuroanatomical correlates of Clock Drawing Test performance were investigated in several studies, but the findings are inconsistent [49–52]. This discrepancy might probably stem from the fact that the Clock Drawing Test measures also executive function, numerical and verbal memory, and visuospatial ability [34, 53].…”

Section: Discussionmentioning

confidence: 99%

Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease

Eichelberger

Calabrese

Meyer

et al. 2017

Parkinson's Disease

View full text Add to dashboard Cite

Background. Visuospatial dysfunction is among the first cognitive symptoms in Parkinson's disease (PD) and is often predictive for PD-dementia. Furthermore, cognitive status in PD-patients correlates with quantitative EEG. This cross-sectional study aimed to investigate the correlation between EEG slowing and visuospatial ability in nondemented PD-patients. Methods. Fifty-seven nondemented PD-patients (17 females/40 males) were evaluated with a comprehensive neuropsychological test battery and a high-resolution 256-channel EEG was recorded. A median split was performed for each cognitive test dividing the patients sample into either a normal or lower performance group. The electrodes were split into five areas: frontal, central, temporal, parietal, and occipital. A linear mixed effects model (LME) was used for correlational analyses and to control for confounding factors. Results. Subsequently, for the lower performance, LME analysis showed a significant positive correlation between ROCF score and parietal alpha/theta ratio (b = .59, p = .012) and occipital alpha/theta ratio (b = 0.50, p = .030). No correlations were found in the group of patients with normal visuospatial abilities. Conclusion. We conclude that a reduction of the parietal alpha/theta ratio is related to visuospatial impairments in PD-patients. These findings indicate that visuospatial impairment in PD-patients could be influenced by parietal dysfunction.

show abstract

Neural correlates of performance on the different scoring systems of the clock drawing test

Cited by 32 publications

References 23 publications

Side and Type of Initial Motor Symptom Influences Visuospatial Functioning in Parkinson's Disease

Side and Type of Initial Motor Symptom Influences Visuospatial Functioning in Parkinson's Disease

Cognitive and connectome properties detectable through individual differences in graphomotor organization

Correlation of Visuospatial Ability and EEG Slowing in Patients with Parkinson’s Disease

Contact Info

Product

Resources

About