Neural correlates of spatial working memory in humans: A functional magnetic resonance imaging study comparing visual and tactile processes

Ricciardi, Emiliano; Bonino, Daniela; Gentili, Claudio; Sani, Lorenzo; Pietrini, Pietro; Vecchi, Tomaso

doi:10.1016/j.neuroscience.2005.08.045

Cited by 151 publications

(117 citation statements)

References 36 publications

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“…A similar conclusion was drawn by a recent human fMRI study on haptic working memory (Kaas et al, 2007). Mounting evidence in human studies also shows that PPC plays an important role in tactile working memory (e.g., Burton and Sinclair, 2000;Stoeckel et al, 2003;Ricciardi et al, 2006)). …”

Section: Introductionsupporting

confidence: 78%

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Neural activities of tactile cross-modal working memory in humans: an event-related potential study

Ohara

Wang

et al. 2008

Neuroscience

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In the present study, we examined the neural mechanisms underlying crossmodal working memory by analyzing scalp-recorded event-related potentials (ERPs) from normal human subjects performing tactile-tactile unimodal or tactile-auditory crossmodal delay tasks that consisted of stimulus-1 (S-1, tactile), interval (delay), and stimulus-2 (S-2, tactile or auditory). We hypothesized that there are sequentially discrete task-correlated changes in ERPs representing neural processes of tactile working memory, and in addition, significant differences would be observed in ERPs between the unimodal task and the crossmodal task.In comparison to the ERP components in the unimodal task, two late positive ERP components (LPC-1 and LPC-2) evoked by the tactile S-1 in the delay of the crossmodal task were enhanced by expectation of the associated auditory S-2 presented at the end of the delay. Such enhancement might represent neural activities involved in crossmodal association between the tactile stimulus and the auditory stimulus. Later in the delay, a late negative component (LNC) was observed. The amplitude of LNC depended on information retained during the delay, and when the same information was retained, this amplitude was not influenced by modality or location of S-2 (auditory S-2 through headphones, or tactile S-2 on the left index finger). LNC might represent the neural activity involved in working memory. The above results suggest that the sequential ERP changes in the present study represent temporally distinguishable neural processes, such as the crossmodal association and crossmodal working memory.

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Section: Introductionsupporting

confidence: 78%

“…In recent human studies, the PFC has been found to be involved in tactile object recognition (Deibert et al, 1999;Stoeckel et al, 2003), and tactile working memory (Ricciardi et al, 2006;Soros et al, 2007).…”

Section: Erp Componentsmentioning

confidence: 99%

Neural activities of tactile cross-modal working memory in humans: an event-related potential study

Ohara

Wang

et al. 2008

Neuroscience

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“…It is well established from studies in monkeys and humans that the posterior parietal cortex, and more specifically LIP, is crucial for spatial attention (Corbetta et al, 2002;Bisley and Goldberg, 2003;Owen et al, 2006). Attending to and tracking an object in space also involves working memory (Ricciardi et al, 2006;Offen et al, 2010), which may explain the DLPFC activation in our IOM task.…”

Section: Discussionmentioning

confidence: 92%

Functional Parcellation of the Lateral Mesencephalus

Karachi¹,

André²,

Bertasi³

et al. 2012

Journal of Neuroscience

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The mesencephalic locomotor region (MLR), which includes the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CN), has been recently identified as a key structure for locomotion and gait control in mammals. However, the function and the precise anatomy of the MLR remain unclear in humans. To study the lateral mesencephalus, we used fMRI in 15 right-handed healthy volunteers performing two tasks: imagine walking in a hallway and imagine an object moving along the same hallway. Both tasks were performed at two different speeds: normal and 30% faster. We identified two distinct networks of cortical activation: one involving motor/premotor cortices and the cerebellum for the walking task and the other involving posterior parietal and dorsolateral prefrontal cortices for the object moving task. In the lateral mesencephalus, we found that two different but anatomically connected parts of the MLR were activated during the fast condition of each task. The CN and the dorsal part of the PPN were activated during the fast imaginary walking task, whereas the ventral part of the PPN and the ventral part of the reticular formation were activated while subjects were imagining the object moving fast. Our data suggest that the lateral mesencephalus participates in different aspects of gait in humans, with the CN and dorsal PPN controlling motor aspects of locomotion and the ventral PPN being involved in integrating sensory information.

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“…Clusters of significantly active voxels were found in regions frequently identified as contributing to VSWM tasks, including bilateral FEF, right SEF, bilateral anterior inferior parietal lobule, left IPS, right caudate, and left DLPFC (BA 10/46) (e.g., Sweeney et al, 1995Sweeney et al, , 1996McCarthy et al, 1996;Courtney et al, 1997Courtney et al, , 1998Smith and Jonides, 1998;Ungerleider et al, 1998;LaBar et al, 1999;Luna et al, 1999;Cabeza and Nyberg, 2000;Hartley and Speer, 2000;Postle et al, 2000a, b;Rowe et al, 2000;Berman and Colby, 2002;Leung et al, 2002;Manoach et al, 2003;Wager and Smith, 2003;Brown et al, 2004a,b;Curtis et al, 2004Curtis et al, , 2005Passingham and Sakai, 2004;Schluppeck et al, 2005Schluppeck et al, , 2006Curtis and D'Esposito, 2006;Keedy et al, 2006;Klingberg, 2006;Ricciardi et al, 2006;Ranganath, 2006;Postle, 2006;Scherf et al, 2006). The fact that these regions, along with others listed in Table 1, were recruited despite differences in the maintenance duration requirements suggests that they support 'core' components of visual spatial working memory task performance such as encoding, response planning, fundamental aspects of maintenance, and/or the motor response.…”

Section: Discussionmentioning

confidence: 99%

“…Delay-contingent reductions in firing patterns have also been observed in substantia nigra pars reticulata (SNpr) (Hikosaka and Wurtz, 1983). In humans, numerous neuroimaging studies collectively implicate recruitment of a widely distributed system supporting working memory, including dorsolateral prefrontal cortex (DLPFC), FEF, SEF, intraparietal sulcus (IPS), cingulate cortex, basal ganglia, and lateral cerebellum (e.g., Sweeney et al, 1995Sweeney et al, , 1996McCarthy et al, 1996;Courtney et al, 1997Courtney et al, , 1998Smith and Jonides, 1998;Ungerleider et al, 1998;LaBar et al, 1999;Luna et al, 1999;Cabeza and Nyberg, 2000;Hartley and Speer, 2000;Postle et al, 2000a,b;Rowe et al, 2000;Berman and Colby, 2002;Leung et al, 2002;Manoach et al, 2003;Wager and Smith, 2003;Brown et al, 2004a,b;Curtis et al, 2004Curtis et al, , 2005Passingham and Sakai, 2004;Curtis and D'Esposito, 2006;Keedy et al, 2006;Klingberg, 2006;Ricciardi et al, 2006;Ranganath, 2006;Scherf et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Circuitry underlying temporally extended spatial working memory

2007

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Extended maintenance delays decrease the accuracy of information stored in spatial working memory. In order to elucidate the network underlying sustained spatial working memory, 16 subjects were scanned using fast event-related fMRI as they performed an oculomotor delayed response task containing trials with "short" (2.5 s) or "long" (10 s) delay periods. Multiple cortical and subcortical regions were common to both delay trial types indicating core task regions. Three patterns of activity were found in a subset of core regions that reflect underlying processes: maintenance-related (e.g., left FEF, right supramarginal gyrus (SMG)), response planning-related (e.g., right FEF, SEF), and motor response-related (e.g., lateral cerebellum (declive)) activation. Several regions were more active during long than short delay trials, including multiple sites in DLPFC (BA 9, 46), indicating a circuitry dynamically recruited to support sustained working memory. Our results suggest that specialized brain processes support extended periods of working memory.

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Neural correlates of spatial working memory in humans: A functional magnetic resonance imaging study comparing visual and tactile processes

Cited by 151 publications

References 36 publications

Neural activities of tactile cross-modal working memory in humans: an event-related potential study

Neural activities of tactile cross-modal working memory in humans: an event-related potential study

Functional Parcellation of the Lateral Mesencephalus

Circuitry underlying temporally extended spatial working memory

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