Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder

Jaspers‐Fayer, Fern; Lin, Senshang; Chan, Elisa K.; Ellwyn, Rhonda; Lim, Ryan; Best, John R.; Belschner, Laura; Lang, Donna J.; Heran, Manraj; Woodward, Todd S.; Stewart, S. Evelyn

doi:10.1016/j.nicl.2019.102034

Cited by 10 publications

(9 citation statements)

References 48 publications

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“…High resolution structural MRI enabled morphometric analyses of subcortical volume and shape, cortical thickness and surface area, as well as cortical gyrification. Functional MRI (fMRI) began to be used to visualize brain activation patterns during specific states relevant to the disorder, using a range of emotional and cognitive paradigms that may be crucial in the disease, for example, symptom provocation (Jaspers-Fayer et al, 2019;Thorsen et al, 2018), fear and extinction learning (Milad et al, 2013), response inhibition (Norman et al, 2019), planning (e.g., Van den Heuvel et al, 2005), working memory (e.g., De Vries et al, 2014), and reversal learning (e.g., Remijnse et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration

Heuvel¹,

Boedhoe²,

Bertolín³

et al. 2020

Human Brain Mapping

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Neuroimaging has played an important part in advancing our understanding of the neurobiology of obsessive-compulsive disorder (OCD). At the same time, neuroimaging studies of OCD have had notable limitations, including reliance on relatively small samples. International collaborative efforts to increase statistical power by combining samples from across sites have been bolstered by the ENIGMA consortium; this provides specific technical expertise for conducting multi-site analyses, as well as access to a collaborative community of neuroimaging scientists. In this article, we outline the background to, development of, and initial findings from ENIGMA's OCD working group, which currently consists of 47 samples from 34 institutes in 15 countries on 5 continents, with a total sample of 2,323 OCD

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Section: Introductionmentioning

confidence: 99%

An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration

Heuvel¹,

Boedhoe²,

Bertolín³

et al. 2020

Human Brain Mapping

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“…As for OCD, the superior temporal gyrus was documented to be specifically associated with social anhedonia in OCD [ 66 ]. Moreover, greater recruitment of the left superior temporal gyrus was found in pediatric participants with OCD than HC during combined symptom provocation, which suggested the involvement of the temporal poles in pediatric OCD during symptom provocation [ 67 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of resting-state spontaneous brain activity between treatment-naive schizophrenia and obsessive-compulsive disorder

Qiu

Huang

et al. 2021

BMC Psychiatry

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Background Schizophrenia (SZ) and obsessive-compulsive disorder (OCD) share many demographic characteristics and severity of clinical symptoms, genetic risk factors, pathophysiological underpinnings, and brain structure and function. However, the differences in the spontaneous brain activity patterns between the two diseases remain unclear. Here this study aimed to compare the features of intrinsic brain activity in treatment-naive participants with SZ and OCD and to explore the relationship between spontaneous brain activity and the severity of symptoms. Methods In this study, 22 treatment-naive participants with SZ, 27 treatment-naive participants with OCD, and sixty healthy controls (HC) underwent a resting-state functional magnetic resonance imaging (fMRI) scan. The amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo) and degree of centrality (DC) were performed to examine the intrinsic brain activity of participants. Additionally, the relationships among spontaneous brain activity, the severity of symptoms, and the duration of illness were explored in SZ and OCD groups. Results Compared with SZ group and HC group, participants with OCD had significantly higher ALFF in the right angular gyrus and the left middle frontal gyrus/precentral gyrus and significantly lower ALFF in the left superior temporal gyrus/insula/rolandic operculum and the left postcentral gyrus, while there was no significant difference in ALFF between SZ group and HC group. Compared with HC group, lower ALFF in the right supramarginal gyrus/inferior parietal lobule and lower DC in the right lingual gyrus/calcarine fissure and surrounding cortex of the two patient groups, higher ReHo in OCD group and lower ReHo in SZ group in the right angular gyrus/middle occipital gyrus brain region were documented in the present study. DC in SZ group was significantly higher than that in HC group in the right inferior parietal lobule/angular gyrus, while there were no significant DC differences between OCD group and HC group. In addition, ALFF in the left postcentral gyrus were positively correlated with positive subscale score (r = 0.588, P = 0.013) and general psychopathology subscale score (r = 0.488, P = 0.047) respectively on the Positive and Negative Syndrome Scale (PANSS) in SZ group. ALFF in the left superior temporal gyrus/insula/rolandic operculum of participants with OCD were positively correlated with compulsion subscale score (r = 0.463, P = 0.030) on the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). The longer the illness duration in SZ group, the smaller the ALFF of the left superior temporal gyrus/insula/rolandic operculum (Rho = 0.-492, P = 0.020). The longer the illness duration in OCD group, the higher the ALFF of the right supramarginal gyrus/inferior parietal lobule (Rho = 0.392, P = 0.043) and the left postcentral gyrus (Rho = 0.385, P = 0.048), and the lower the DC of the right inferior parietal lobule/angular gyrus (Rho = − 0.518, P = 0.006). Conclusion SZ and OCD show some similarities in spontaneous brain activity in parietal and occipital lobes, but exhibit different patterns of spontaneous brain activity in frontal, temporal, parietal, occipital, and insula brain regions, which might imply different underlying neurobiological mechanisms in the two diseases. Compared with OCD, SZ implicates more significant abnormalities in the functional connections among brain regions.

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“…First, all correlation analyses on the temporal correlation coefficients were repeated with patients’ daily doses of antidepressant (fluoxetine equivalents) as an additional covariate (using the partial Spearman’s correlations). Second, the relationships between temporal correlation coefficients and HAMD item 3 scores were investigated using an ordinal logistic regression model [ 46 ], to see whether the observed significant relationships would change in different statistical models.…”

Section: Methodsmentioning

confidence: 99%

Temporal Stability of Dynamic Default Mode Network Connectivity Negatively Correlates with Suicidality in Major Depressive Disorder

Ouyang

Long

et al. 2022

Brain Sciences

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Previous studies have demonstrated that the suicidality in patients with major depressive disorder (MDD) is related to abnormal brain functional connectivity (FC) patterns. However, little is known about its relationship with dynamic functional connectivity (dFC) based on the assumption that brain FCs fluctuate over time. Temporal stabilities of dFCs within the whole brain and nine key networks were compared between 52 MDD patients and 21 age, sex-matched healthy controls (HCs) using resting-state functional magnetic resonance imaging and temporal correlation coefficients. The alterations in MDD were further correlated with the scores of suicidality item in the Hamilton Rating Scale for Depression (HAMD). Compared with HCs, the MDD patients showed a decreased temporal stability of dFC as indicated by a significantly decreased temporal correlation coefficient at the global level, as well as within the default mode network (DMN) and subcortical network. In addition, temporal correlation coefficients of the DMN were found to be significantly negatively correlated with the HAMD suicidality item scores in MDD patients. These results suggest that MDD may be characterized by excessive temporal fluctuations of dFCs within the DMN and subcortical network, and that decreased stability of DMN connectivity may be particularly associated with the suicidality in MDD.

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Neural correlates of symptom provocation in pediatric obsessive-compulsive disorder

Abstract: HighlightsLargest controlled pediatric OCD symptom provocation study.Novel standardized symptom provocation picture set for pediatric OCD.Behavioral group differences strongest for ‘Just Right’ factor.Temporal pole recruited by OCD group.

Cited by 10 publications

References 48 publications

An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration

An overview of the first 5 years of the ENIGMA obsessive–compulsive disorder working group: The power of worldwide collaboration

Comparison of resting-state spontaneous brain activity between treatment-naive schizophrenia and obsessive-compulsive disorder

Temporal Stability of Dynamic Default Mode Network Connectivity Negatively Correlates with Suicidality in Major Depressive Disorder

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