Neural correlates of valence generalization in an affective conditioning paradigm

Schick, Anita; Adam, Ruth; Vollmayr, Barbara; Kuehner, Christine; Kanske, Philipp; Wessa, Michèle

doi:10.1016/j.bbr.2015.06.009

Cited by 10 publications

(14 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Taken together, these findings suggest that affective biases associated with different cognitive processes, as well as those induced by rapid versus delayed onset antidepressants, are likely to have different underlying neurobiology. The observation of positive judgement biases across timescales matching subjective changes in mood means that this task, which has been translated for use in humans ( Paul et al, 2011 , Anderson et al, 2012 , Schick et al, 2013 , Schick et al, 2015 ), may offer a valuable method to further investigate these differences.…”

Section: Discussionmentioning

confidence: 99%

Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats

Hales

Houghton

Robinson

2017

European Neuropsychopharmacology

View full text Add to dashboard Cite

Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders. Until the recent discovery of the rapid onset antidepressant action of ketamine, pharmacological treatments for MDD were limited to conventional antidepressant drugs with delayed clinical efficacy. Using a judgement bias task, this study has investigated whether the temporal differences observed in patients would be reflected in affective biases and decision making behaviour in rodents. The diffusion model was also used to investigate the underlying decision making processes. Positive biases were induced in this task over timeframes that mirror the rapid versus delayed antidepressant efficacy of the drugs in clinical populations. Diffusion modelling revealed that the antidepressants tested also have different effects on decision making processes, suggesting they may act through different neurobiological substrates. This combination of behaviour and computational modelling may provide a useful approach to further investigate the mechanisms underlying rapid antidepressant effect and assess potential new treatments.

show abstract

Section: Discussionmentioning

confidence: 99%

Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats

Hales

Houghton

Robinson

2017

European Neuropsychopharmacology

View full text Add to dashboard Cite

show abstract

“…Ruminative coping and anxiety have been found to be associated with bias score in the JBT 31 . To control for ruminative coping and anxiety, a 10-item subset of the Ruminative Responses Scale (RRS) 41 and the State-Trait Anxiety Inventory (STAI) 42 were administrated.…”

Section: Methodsmentioning

confidence: 97%

“…The pitches were selected according to the Bark Frequency Scale 60 so that any pair of two adjacent tones are perceived as acoustically equidistant. The same parameters have been used in previous JBT studies 30,31 . A pilot study confirmed the effectiveness of the acoustic parameters (data not presented).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Ambiguity Processing Bias Induced by Depressed Mood Is Associated with Diminished Pleasantness

Lin

Sun

Wang

et al. 2019

Sci Rep

View full text Add to dashboard Cite

Depressed individuals are biased to perceive, interpret, and judge ambiguous cues in a negative/pessimistic manner. Depressed mood can induce and exacerbate these biases, but the underlying mechanisms are not fully understood. We theorize that depressed mood can bias ambiguity processing by altering one’s subjective emotional feelings (e.g. pleasantness/unpleasantness) of the cues. This is because when there is limited objective information, individuals often rely on subjective feelings as a source of information for cognitive processing. To test this theory, three groups (induced depression vs. spontaneous depression vs. neutral) were tested in the Judgement Bias Task (JBT), a behavioral assay of ambiguity processing bias. Subjective pleasantness/unpleasantness of cues was measured by facial electromyography (EMG) from the zygomaticus major (ZM, “smiling”) and from the corrugator supercilii (CS, “frowning”) muscles. As predicted, induced sad mood (vs. neutral mood) yielded a negative bias with a magnitude comparable to that in a spontaneous depressed mood. The facial EMG data indicates that the negative judgement bias induced by depressed mood was associated with a decrease in ZM reactivity (i.e., diminished perceived pleasantness of cues). Our results suggest that depressed mood may bias ambiguity processing by affecting the reward system.

show abstract

“…rats [14], [15], [16], [17], [18], [19], [20]; mice [21], [22]; hamsters [23]; dogs [24], [25]; sheep [26], [27]; pigs [28], [29]; cattle [30], [31]; monkeys [32], [33]; peccary [34]), birds (e.g. starling [35], [36]; chicken [37], [38]), and insects [39], [40], [41], and it has also been back-translated to humans [42], [43], [44], [45]. A variety of affect manipulations has been employed.…”

Section: Introductionmentioning

confidence: 99%

Pavlovian influences on learning differ between rats and mice in a counter-balanced Go/NoGo judgement bias task

Jones

Paul

Dayan

et al. 2017

Behavioural Brain Research

View full text Add to dashboard Cite

HighlightsWe develop an automated counter-balanced Go/NoGo judgement bias task for rodents.Rats learn Go-for-reward/NoGo-to-avoid-punishment but not the reverse contingency.Mice do exactly the opposite; species may differ in Pavlovian control of decisions.Foraging, predator avoidance, and baseline activity may influence Pavlovian control.Both species show the predicted generalisation of responses in ambiguity tests.

show abstract

Neural correlates of valence generalization in an affective conditioning paradigm

Cited by 10 publications

References 47 publications

Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats

Behavioural and computational methods reveal differential effects for how delayed and rapid onset antidepressants effect decision making in rats

Ambiguity Processing Bias Induced by Depressed Mood Is Associated with Diminished Pleasantness

Pavlovian influences on learning differ between rats and mice in a counter-balanced Go/NoGo judgement bias task

Contact Info

Product

Resources

About