Neural correlates of verbal working memory in children with epilepsy with centro-temporal spikes

Ciumas, Carolina; Montavont, Alexandra; Ilski, Faustine; Laurent, Agathe; Saignavongs, Mani; Lachaux, Jean-Philippe; Bellescize, Julitta de; Panagiotakaki, Eleni; Ostrowsky‐Coste, Karine; Herbillon, Vania; Ibarrola, Danielle; Hermier, M.; Arzimanoglou, Alexis; Ryvlin, Philippe

doi:10.1016/j.nicl.2020.102392

Cited by 6 publications

(3 citation statements)

References 103 publications

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“…It was previously reported that children with BECTS had early cognitive impairment, similar to the findings obtained [14]. Further studies also revealed that children with BECTS not only had a lower accuracy and response time in working memory tasks [39] but also performed poorly in reading comprehension and word reading [40]. Although there was no significant difference in test scores between the U-BECTS and B-BECTS groups, children in the B-BECTS group scored significantly lower in the Perceptual Reasoning Index (PRI) test than those in the control category.…”

Section: Clinical Characteristics and Neuropsychological Testssupporting

confidence: 85%

“…A previous magnetoencephalographic study reported that better cognitive performance was related to higher C and lower L values in certain frequency bands, which make the brain integrate and process information more effectively [61,62]. Moreover, differing from their healthy counterparts in how they controlled working memory processes, children with BECTS showed reduced activation in the frontal, temporal, and parietal regions as well as in behavioral performances [39]. To assess the impact of dominant hemisphere on cognitive profiles, we investigated separately the correlation between clinical characteristics, cognitive function, and FC network parameters in patients with U-BECTS with left or right spikes.…”

Section: Correlation Analysismentioning

confidence: 94%

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Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study

Wang

Sun

et al. 2021

Epilepsy & Behavior

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Objective: Rolandic epilepsy (RE) is one of the most common forms of epilepsy syndromes in children. The condition is usually accompanied with either unilateral or bilateral centrotemporal epileptic discharge. Despite the term ''benign", many studies have reported that children with benign epilepsy with centrotemporal spikes (BECTS) display a range of pervasive cognitive difficulties. In addition, existing research suggests that unilateral and bilateral centrotemporal spikes may affect cognition through different mechanisms. Consequently, the present study aimed to investigate cognitive impairment and the resting-state network topology of children with benign epilepsy with unilateral centrotemporal spikes (U-BECTS) and with bilateral centrotemporal spikes (B-BECTS). Methods: This study recruited 14 children with U-BECTS and 14 with B-BECTS. Thereafter, cognition was assessed in 28 children with BECTS and 14 healthy controls, using the fourth edition of the Wechsler Intelligence Scale (WISC-IV). Additionally, the functional network of the brain was constructed through magnetoencephalography (MEG) to record the resting-state brain magnetic signals of the brain and by computing virtual sensor waveforms at the source level. Moreover, graph theory (GT) analysis was used to assess the properties of the brain network. Results: Children in the B-BECTS group had an earlier onset of epilepsy compared to those in the U-BECTS category. In addition, both the B-BECTS and U-BECTS groups had lower Full Scale Intelligence Quotient (FSIQ), Verbal Comprehension Index (VCI), and Working Memory Index (WMI) scores, compared to the healthy controls although only children in the B-BECTS category had lower Perceptual Reasoning Index (PRI) scores. The results also showed that both BECTS groups had increased frontal cortex connectivity in specific frequency bands. Notably, children with B-BECTS showed a more disorderly and randomized network in the 1-4-Hz and 80-250-Hz frequency bands. Moreover, GT analysis showed that children with B-BECTS had lower clustering coefficient and characteristic path length in the 80-250-Hz frequency bands and higher connection strength in the 4-8-Hz frequency bands. On the other hand, the U-BECTS group had a higher clustering coefficient in the 8-12-Hz frequency bands, compared to the healthy controls. Correlation analysis revealed that there were negative correlations between network parameters, clinical characteristics, and neuropsychological data in the U-BECTS category. Conclusion:The findings revealed that children with BECTS display a diffuse early cognitive deficit. In addition, resting-state suboptimal network topology may be the mechanism of cognitive impairment in children with BECTS. The study also showed that and children with B-BECTS may be at a higher risk of cognitive impairment.

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Section: Clinical Characteristics and Neuropsychological Testssupporting

confidence: 85%

Section: Correlation Analysismentioning

confidence: 94%

Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study

Wang

Sun

et al. 2021

Epilepsy & Behavior

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“…There was also a significant positive correlation between abnormal EC and the number of seizures in the medicated group, which indicated that abnormal EC could be improved by effective antiseizure medications (ASMs) and reductions in the number of seizures. A previous study of fMRI and verbal working memory tasks in BECTS patients also found that the greater the number of seizures, the greater the abnormal activation of these regions [ 37 ]. It was also found that the association between altered EC strength and cognitive impairment (of verbal memory and language function) was affected by both seizure frequency and lateralization in patients with temporal lobe epilepsy (TLE) [ 21 ].…”

Section: Discussionmentioning

confidence: 99%

Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes

Yang

Tan

Huang

et al. 2023

Life

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Benign childhood epilepsy with centrotemporal spikes (BECTS) is one of the most common childhood epilepsy syndromes and may be associated with language deficits. Resting-state functional magnetic resonance imaging (fMRI) data were collected from a total of 78 children: 52 patients with BECTS (28 drug-naïve and 24 medicated) and 26 healthy controls (HC). Granger causality analysis (GCA) was used to investigate alterations in effective connectivity (EC) between the language network core node (Broca’s area) and the whole brain. EC from Broca’s area to the left Heschl’s gyrus (HG), right putamen, and anterior cingulate cortex (ACC) was significantly increased, while EC from the bilateral putamen and left ACC to Broca’s area was significantly decreased in BECTS. Moreover, altered EC of Broca’s area to the right putamen was significantly positively correlated with verbal IQ (VIQ), while altered EC of Broca’s area to the ACC showed significantly negative correlations with the frequency of seizures. Altered EC from the left putamen to Broca’s area was also significantly negatively correlated with performance IQ (PIQ) and full-scale IQ (FSIQ) in the drug-naïve group. In addition, there was a significant positive correlation between the EC of Broca’s area to the left HG and the number of seizures, as well as between the EC of Broca’s area to the right putamen and the age at onset in the medicated group. These findings suggest abnormal causal effects on the language network related to Broca’s area in children with BECTS. Longitudinal investigation of language network development and further follow-up may be needed to illuminate the changes in organization and rebalancing over time.

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Brain metabolic characteristics distinguishing typical and atypical benign epilepsy with centro-temporal spikes

Feng

Zhang

et al. 2021

Eur Radiol

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Neural correlates of verbal working memory in children with epilepsy with centro-temporal spikes

Cited by 6 publications

References 103 publications

Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study

Altered functional connectivity in newly diagnosed benign epilepsy with unilateral or bilateral centrotemporal spikes: A multi-frequency MEG study

Altered Language-Related Effective Connectivity in Patients with Benign Childhood Epilepsy with Centrotemporal Spikes

Brain metabolic characteristics distinguishing typical and atypical benign epilepsy with centro-temporal spikes

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