Neural correlates of working memory development in adolescent primates

Zhou, Xin; Zhu, Dantong; Qi, Xue-Lian; Li, Sihai; King, Samson; Salinas, Emilio; Stanford, Terrence R.; Constantinidis, Christos

doi:10.1038/ncomms13423

Cited by 41 publications

(51 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The mean age of the subject in the pre-training stage was 6.7, 6.8, and 6.8 years, for the posterior-, mid-, and anterior-dorsal recordings, and 6.7 and 6.5 years for the posterior- and anterior-ventral recordings, respectively. Prefrontal responses are stable in monkeys after they reach this age range 26 . The mean age after training was 8.3, 8.5, and 8.2 years for recordings in the dorsal areas, and 8.6 and 8.9, for the ventral areas, respectively.…”

Section: Resultsmentioning

confidence: 98%

Anterior-posterior gradient of plasticity in primate prefrontal cortex

Riley

Zhou

et al. 2018

Nat Commun

Self Cite

View full text Add to dashboard Cite

The functional organization of the primate prefrontal cortex has been a matter of debate with some models speculating dorso-ventral and rostro-caudal specialization while others suggesting that information is represented dynamically by virtue of plasticity across the entire prefrontal cortex. To address functional properties and capacity for plasticity, we recorded from different prefrontal sub-regions and analyzed changes in responses following training in a spatial working memory task. This training induces more pronounced changes in anterior prefrontal regions, including increased firing rate during the delay period, selectivity, reliability, information for stimuli, representation of whether a test stimulus matched the remembered cue or not, and variability and correlation between neurons. Similar results are obtained for discrete subdivisions or when treating position along the anterior-posterior axis as a continuous variable. Our results reveal that anterior aspects of the lateral prefrontal cortex of non-human primates possess greater plasticity based on task demands.

show abstract

Section: Resultsmentioning

confidence: 98%

Anterior-posterior gradient of plasticity in primate prefrontal cortex

Riley

Zhou

et al. 2018

Nat Commun

Self Cite

View full text Add to dashboard Cite

show abstract

“…The rate of gamma bursts ramped up, and beta rates decreased, at the end of memory delay in anticipation of the comparison of the memories to the forthcoming test objects. This was accompanied by an increase in end-of-delay spiking that is often seen in WM tasks 13,14,15 . Here, we observed it in absence of, and unrelated to, any forthcoming motor response, as did Hussar and Pasternak (2010).…”

Section: Discussionmentioning

confidence: 82%

Gamma and beta bursts during working memory read-out suggest roles in its volitional control

Lundqvist

Herman

Warden

et al. 2017

Preprint

View full text Add to dashboard Cite

Working memory (WM) activity is not as stationary or sustained as previously thought. There are brief bursts of gamma (~55-120 Hz) and beta (~20-35 Hz) oscillations, the former linked to stimulus information in spiking. We examine these dynamics in relation to read-out from WM, which is still not well understood. Monkeys held a sequence of two objects and had to decide if they matched a subsequent sequence. Changes in the balance of beta/gamma suggested their role in WM control. In anticipation of having to use an object for the match decision, there was an increase in spiking information about that object along with an increase in gamma and a decrease in beta. When an object was no longer needed, beta increased and gamma as well as spiking information about that object decreased. Deviations from these dynamics predicted behavioral errors. Thus, turning up or down beta could regulate gamma and the information in working memory.

show abstract

“…The location of the cylinder was visualized with anatomical MRI imaging and stereotaxic coordinates post-surgery. Neurophysiological recordings were obtained as we have described before (Zhou et al, 2016b). Briefly, we used tungsten-coated electrodes with a 200 or 250 µm diameter and 4 MΩ impedance at 1 kHz (FHC, Bowdoinham, ME).…”

Section: Task and Stimulimentioning

confidence: 99%

Prefrontal and Parietal Attractor Networks Mediate Working Memory Judgments

Constantinidis

2020

Preprint

Self Cite

View full text Add to dashboard Cite

for helpful comments on the manuscript. ABSTRACTThe dorsolateral prefrontal cortex plays a critical role in spatial working memory and its activity predicts behavioral responses in delayed response tasks. Here we addressed whether this predictive ability extends to categorical judgments based on information retained in working memory, and is present in other brain areas. We trained monkeys in a novel, Match-Stay, Nonmatch-Go task, which required them to observe two stimuli presented in sequence with an intervening delay period between them. If the two stimuli were different, the monkeys had to saccade to the location of the second stimulus; if they were the same, they held fixation.Neurophysiological recordings were performed in areas 8a and 46 of the dlPFC and 7a and lateral intraparietal cortex (LIP) of the PPC. We hypothesized that random drifts causing the peak activity of the network to move away from the first stimulus location and towards the location of the second stimulus would result in categorical errors. Indeed, for both areas, when the first stimulus appeared in a neuron's preferred location, the neuron showed significantly higher firing rates in correct than in error trials. When the first stimulus appeared at a nonpreferred location and the second stimulus at a preferred, activity in error trials was higher than in correct. The results indicate that the activity of both dlPFC and PPC neurons is predictive of categorical judgments of information maintained in working memory, and the magnitude of neuronal firing rate deviations is revealing of the contents of working memory as it determines performance.

show abstract

Neural correlates of working memory development in adolescent primates

Cited by 41 publications

References 52 publications

Anterior-posterior gradient of plasticity in primate prefrontal cortex

Anterior-posterior gradient of plasticity in primate prefrontal cortex

Gamma and beta bursts during working memory read-out suggest roles in its volitional control

Prefrontal and Parietal Attractor Networks Mediate Working Memory Judgments

Contact Info

Product

Resources

About