Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke

Lam, Timothy K.; Dawson, Deirdre R.; Honjo, Kazuhito; Roß, Bernhard; Binns, Malcolm A.; Stuss, Donald T.; Black, Sandra E.; Chen, J. Jean; Levine, Brian; Fujioka, Takako; Chen, Joyce L.

doi:10.1016/j.jns.2017.11.007

Cited by 32 publications

(28 citation statements)

References 61 publications

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“…Contralesional M1 positively correlated with bilateral cerebellum and negatively with ipsilesional premotor, primary motor, and parietal cortices; contralesional SMA positively correlated with contralesional and ipsilateral cerebellum and contralesional premotor cortex, and negatively with ipsilesional sensorimotor regions. These results confirm previous observations of bilateral sensorimotor region recruitment and increased intrahemispheric coupling among contralesional motor network nodes [108]. In particular, they are in line with studies indicating that ipsilateral premotor cortex, in addition to M1, would support hand movement after stroke [88,109].…”

Section: Discussionsupporting

confidence: 92%

Brain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke

et al. 2020

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Brain-machine interfaces (BMI) permit bypass motor system disruption by coupling contingent neuroelectric signals related to motor activity with prosthetic devices that enhance afferent and proprioceptive feedback to the somatosensory cortex. In this study, we investigated neural plasticity in the motor network of severely impaired chronic stroke patients after an EEG-BMIbased treatment reinforcing sensorimotor contingency of ipsilesional motor commands. Our structural connectivity analysis revealed decreased fractional anisotropy in the splenium and body of the corpus callosum, and in the contralesional hemisphere in the posterior limb of the internal capsule, the posterior thalamic radiation, and the superior corona radiata. Functional connectivity analysis showed decreased negative interhemispheric coupling between contralesional and ipsilesional sensorimotor regions, and decreased positive intrahemispheric coupling among contralesional sensorimotor regions. These findings indicate that BMI reinforcing ipsilesional brain activity and enhancing proprioceptive function of the affected hand elicits reorganization of contralesional and ipsilesional somatosensory and motor-assemblies as well as afferent and efferent connection-related motor circuits that support the partial re-establishment of the original neurophysiology of the motor system even in severe chronic stroke.

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Section: Discussionsupporting

confidence: 92%

Brain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke

et al. 2020

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“…As we known, rTMS could regulate the magnitude of transcallosal inhibition and influence the information interaction of brain functional regions (14, 39). Studies have shown that the activation of the ipsilateral primary motor area (M1) is associated with motor function recovery and amelioration (40, 41). In Jin et al study (42), the effects of rTMS combined with motor training on brain neural activities were investigated based on the method of brain network.…”

Section: Discussionmentioning

confidence: 99%

The Effects of Combined Low Frequency Repetitive Transcranial Magnetic Stimulation and Motor Imagery on Upper Extremity Motor Recovery Following Stroke

et al. 2019

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Objective: To investigate the effects of low frequency transcranial magnetic stimulation (LF-rTMS) combined with motor imagery (MI) on upper limb motor function during stroke rehabilitation. Background: Hemiplegic upper extremity activity obstacle is a common movement disorder after stroke. Compared with a single intervention, sequential protocol or combination of several techniques has been proven to be better for alleviating motor function disorder. Non-invasive neuromodulation techniques such as repetitive transcranial magnetic stimulation (rTMS) and motor imagery (MI) have been verified to augment the efficacy of rehabilitation. Methods: Participants were randomly assigned to 2 intervention cohorts: (1) experimental group (rTMS+MI group) was applied at 1 Hz rTMS over the primary motor cortex of the contralesional hemisphere combined with audio-based MI; (2) control group (rTMS group) received the same therapeutic parameters of rTMS combined with audiotape-led relaxation. LF-rTMS protocol was conducted in 10 sessions over 2 weeks for 30 min. Functional measurements include Wolf Motor Function Test (WMFT), the Fugl-Meyer Assessment Upper Extremity (UE-FMA) subscore, the Box and Block Test (BBT), and the Modified Barthel index (MBI) were conducted at baseline, the second week (week 2) and the fourth week (week 4). Results: All assessments of upper limb function improved in both groups at weeks 2 and 4. In particular, significant differences were observed between two groups at end-intervention and after intervention ( p < 0.05). In these findings, we saw greater changes of WMFT ( p < 0.01), UE-FMA ( p < 0.01), BBT ( p < 0.01), and MBI ( p < 0.001) scores in the experimental group. Conclusions: LF-rTMS combined with MI had a positive effect on motor function of upper limb and can be used for the rehabilitation of upper extremity motor recovery in stroke patients.

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“…For example, Wang et al (2014) stated that subcortical stroke affects not only the intra-network connectivity but also the internetwork RSFC. Lam et al (2018) described the coupling between contra-lesional motor and FPNs correlated with the post-stroke motor outcome. To date, these studies reported the internetwork interactions between stroke patients and controls, yet evaluate the cross-network interactions along the neurorehabilitation process.…”

Section: Introductionmentioning

confidence: 99%

Synchrony Between Default-Mode and Sensorimotor Networks Facilitates Motor Function in Stroke Rehabilitation: A Pilot fMRI Study

Lin²,

Hsu

et al. 2020

Front. Neurosci.

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Stroke is the most common cause of complex disability in Taiwan. After stroke onset, persistent physical practice or exercise in the rehabilitation procedure reorganizes neural assembly for reducing motor deficits, known as neuroplasticity. Neuroimaging literature showed rehabilitative effects specific to the brain networks of the sensorimotor network (SMN) and default-mode network (DMN). However, whether between-network interactions facilitate the neuroplasticity after stroke rehabilitation remains a mystery. Therefore, we conducted the longitudinal assessment protocol of stroke rehabilitation, including three types of clinical evaluations and two types of functional magnetic resonance imaging (fMRI) techniques (resting state and grasp task). Twelve chronic stroke patients completed the rehabilitation protocol for at least 24 h and finished the three-time assessments: before, after rehabilitation, and 1 month after the cessation of rehabilitation. For comparison, age-matched normal controls (NC) underwent the same fMRI evaluation once without repeated measure. Increasing scores of the Fugl-Meyer assessment (FMA) and upper extremity performance test reflected the enhanced motor performances after the stroke rehabilitation process. Analysis of covariance (ANCOVA) results showed that the connections between posterior cingulate cortex (PCC) and iM1 were persistently enhanced in contrast to the pre-rehabilitation condition. The interactions between PCC and SMN were positively associated with motor performances. The enhanced cross-network connectivity facilitates the motor recovery after stroke rehabilitation, but the cross-network interaction was low before the rehabilitation process, similar to the level of NCs. Our findings suggested that crossnetwork connectivity plays a facilitatory role following the stroke rehabilitation, which can serve as a neurorehabilitative biomarker for future intervention evaluations.

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Neural coupling between contralesional motor and frontoparietal networks correlates with motor ability in individuals with chronic stroke

Cited by 32 publications

References 61 publications

Brain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke

Brain–Machine Interface Induced Morpho-Functional Remodeling of the Neural Motor System in Severe Chronic Stroke

The Effects of Combined Low Frequency Repetitive Transcranial Magnetic Stimulation and Motor Imagery on Upper Extremity Motor Recovery Following Stroke

Synchrony Between Default-Mode and Sensorimotor Networks Facilitates Motor Function in Stroke Rehabilitation: A Pilot fMRI Study

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