2017
DOI: 10.1038/srep45645
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Neural Crest Cells Contribute an Astrocyte-like Glial Population to the Spleen

Abstract: Neural crest cells (NCC) are multi-potent cells of ectodermal origin that colonize diverse organs, including the gastrointestinal tract to form the enteric nervous system (ENS) and hematopoietic organs (bone marrow, thymus) where they participate in lymphocyte trafficking. Recent studies have implicated the spleen as an anatomic site for integration of inflammatory signals from the intestine with efferent neural inputs. We have previously observed alterations in splenic lymphocyte subsets in animals with defec… Show more

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Cited by 18 publications
(13 citation statements)
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“…Non‐myelinating Schwann cells in the spleen (spleen glia) associate with axons and are derived from the neural crest (Barlow‐Anacker, Fu, Erickson, Bertocchini, & Gosain, 2017; Felten et al, 1987; Heusermann & Stutte, 1977). The spleen is the largest secondary lymphoid organ and plays a vital role in detecting bloodborne antigens and conferring immunologic memory.…”
Section: Introductionmentioning
confidence: 99%
“…Non‐myelinating Schwann cells in the spleen (spleen glia) associate with axons and are derived from the neural crest (Barlow‐Anacker, Fu, Erickson, Bertocchini, & Gosain, 2017; Felten et al, 1987; Heusermann & Stutte, 1977). The spleen is the largest secondary lymphoid organ and plays a vital role in detecting bloodborne antigens and conferring immunologic memory.…”
Section: Introductionmentioning
confidence: 99%
“…3A). Of note, EdnrB expression has also been described in NCC-derived perivascular cells that adopt an astrocyte-like, glial lineage in the spleen (19), indicating that multiple cell types express EdnrB in the spleen (Fig. 3B).…”
Section: Splenic B Lymphocytes Express Ednrbmentioning
confidence: 88%
“…In particular, by 6 WGA, the first parasympathetic ganglia can be detected (Müller and O'Rahilly, 1989 ) and, by 10 WGA, the sympathetic trunks have appeared throughout the vertebral column (Kruepunga et al, 2021 ) and, apart from the colonic loop, the extrinsic innervation of the enteric nervous system (ENS) is complete (Kruepunga et al, 2020 ). Neural crest cells also contribute to spleen development (Barlow-Anacker et al, 2017 ). The spleen begins to develop at 5 WGA as a lobulated organ, appears clearly around 8 WGA, and initially functions as a hematopoietic center; then, during fetal development, it gradually loses both this role and its lobules (Moore et al, 2016 ; Hill, 2021a ).…”
Section: The Fetal Ans Development: the Search Of “Critical Windows”mentioning
confidence: 99%