Neural differentiation in Wilms' Tumor

Magee, Fergall; Mah, Richard; Taylor, Glenn; Dimmick, James E.

doi:10.1016/s0046-8177(87)80190-9

Cited by 31 publications

(7 citation statements)

References 12 publications

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“…In reported cases of WT, neural differentiation has been well-described in focal areas of the tumors. [24][25][26] Ganglion cells were most commonly identified, followed by Schwannian stroma. Rosettes and astrocytes have rarely been observed.…”

Section: Discussionmentioning

confidence: 99%

Adult teratoid Wilms' tumor with prominent neuroepithelial differentiation

Seo¹,

Suh²,

Choi³

2008

Pathology International

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Teratoid Wilms' tumor is a rare variant of Wilms' tumor (WT) that has been reported exclusively in pediatric patients. The present paper describes a teratoid WT in a 50-year-old Korean man with a giant right renal mass. Radical nephrectomy was performed under the impression that the mass was a renal cell carcinoma. Grossly, the removed kidney contained a giant well-encapsulated mass measuring 24 x 18 x 10 cm with cystic changes, necrosis, and hemorrhage. On microscopy triphasic patterns of WT and prominent heterologous components were seen, including rhabdomyoblasts, neuroepithelial tissue, fat, cartilage, and various types of mature epithelium. This is the first reported case of a teratoid WT occurring in an adult kidney.

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Section: Discussionmentioning

confidence: 99%

Adult teratoid Wilms' tumor with prominent neuroepithelial differentiation

Seo¹,

Suh²,

Choi³

2008

Pathology International

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“…In three of the tumour children, the malignancy originated from neuroectodermal tissue. Tumour cells of neuroectodermal origin have stained positive for S‐100 in immunohistochemical investigations ( 17,18). Direct manipulation of this kind of tissue might explain the high S‐100 concentrations seen in these patients.…”

Section: Discussionmentioning

confidence: 99%

Increased levels of S‐100 protein after cardiac surgery with cardiopulmonary bypass and general surgery in children

Jensen

Sandström

Andréasson

et al. 2000

Pediatric Anesthesia

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The aim of this study was to evaluate changes in concentrations of the neurospecific protein S-100 in relation to cardiac surgery with cardiopulmonary bypass (CPB) and noncardiac general surgery in children below 3 years of age. Seventeen children underwent surgery for congenital heart disease and all survived without clinical signs of neurological complications. Samples for plasma concentrations of S-100 in these patients were taken on three occasions in connection with surgery: before the start of surgery, after CPB and finally 16-20 h after CPB. In the noncardiac group of 31 children, S-100 concentrations were measured on two occasions: before surgery and during surgery. In both groups, a significant increase in S-100 concentrations was observed during surgery, although the increase in the CPB group was significantly higher than in the noncardiac group. The CPB group included four children with Down's syndrome who had higher mean S-100 concentrations on all sampling occasions compared to the remaining patients. The peak S-100 concentrations after cardiac surgery were related to the duration of CPB, the time from the termination of CPB to the first post-CPB sample, as well as mean arterial pressure and cerebral arteriovenous lactate difference during rewarming. All the children studied (Down's patients excluded) had age-dependent plasma concentrations of S-100 measured before surgery. It can be concluded that CPB initiates a marked but transient release of S-100 into the systemic circulation during open heart surgery in children who are not developing clinical signs of neurological sequelae.

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“…Beckwith [12] listed neuroglial epithelium among the various tissues observed in WTs in the American National Wilms' Tumor Study Pathology Center. Magee et al [13] found that four out of 48 cases of WT were positive for glial fibrillary acidic protein.…”

Section: Discussionmentioning

confidence: 99%

Adult teratoid Wilms’ tumor: A case report of rare variant with predominant neuroepithelium

El-Hawary

Zalata

El‐Baz

et al. 2014

CRCP

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Teratoid Wilms' tumor (WT) is a rare variant of nephroblastoma which had been only reported in pediatric patients. Herein, we report a 32-years-old female patient with teratoid WT with predominant heterologous neuroepithelial component of the right kidney. Histologically, the tumor showed the typical histological features of a teratoid WT formed of triphasic pattern of blastema, epithelium and stroma with heterologous elements which comprised more than 50% of the tumor area. The heterologous elements were mainly composed of neuroepithelial tissue including ganglion cells, differentiating neuroblasts, true and pseudorosettes, ganglioneuromatous differentiation, schwannianstroma, abundant neuropils admixed with mature types of epithelium and rhabdomyoblasts. This was the second reported case of adult teratoid WT with extensive neuroepithelial differentiation.

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Neural differentiation in Wilms' Tumor

Cited by 31 publications

References 12 publications

Adult teratoid Wilms' tumor with prominent neuroepithelial differentiation

Adult teratoid Wilms' tumor with prominent neuroepithelial differentiation

Increased levels of S‐100 protein after cardiac surgery with cardiopulmonary bypass and general surgery in children

Adult teratoid Wilms’ tumor: A case report of rare variant with predominant neuroepithelium

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