Neural differentiation of mesenchymal-like stem cells from cord blood is mediated by PKA

Migration of Neurotrophic Factors-Secreting Mesenchymal Stem Cells Toward a Quinolinic Acid Lesion as Viewed by Magnetic Resonance Imaging

“…Normally, mature stem cells are supposed to be committed to their lineage. However, several recent reports have shown the differentiation capabilities of MSCs toward the neural lineages under specific medium conditions [31][32][33][34][35][36][37]. Our group has previously shown [6], as have others [38,39], that MSCs basally express several neural markers and NTFs.…”

Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells

“…To support the clinical potential of BMSC transplantation, many attempts to differentiate BMSCs in vitro into neural cells have been made. In this connection, a few results showing the molecular pathways and gene expression patterns specific for in vitro neuronal differentiation of mesenchymal stem cells have been published (Jori et al, 2005;Wang et al, 2007). However, precise mechanism for neuronal differentiation or functional role of BMSCs in the brain still remains to be determined.…”

Neural Differentiation of Human Umbilical Cord Blood-derived Mesenchymal Stem Cells

“…The time-duration for the emergence of MSCNPCs and various types of neural markers depends on the culture system used. Tio and Wang's method showed the longest duration for which no basal medium was provided (27,28). In contrast, we found that if B-ME was used immediately from the start, MSC-NPCs failed to form.…”

“…Tio and Wang used the same culture protocol, with some differences (27,28). Woodbury used a culture protocol by adding in the first week of culture followed a simple medium with serum (16).…”