Neural distribution of the nuclear progesterone receptor in the túngara frog, Physalaemus pustulosus

O’Connell, Lauren A.; Ding, James; Ryan, Michael J.; Hofmann, Hans A.

doi:10.1016/j.jchemneu.2011.01.002

Cited by 16 publications

(11 citation statements)

References 86 publications

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“…The amphibian POA is similar to the mammalian POA in neurochemistry, hodology, and topography, as this hypothalamic region lies along the third ventricle and contains sex steroid hormone receptors (Kelley et al, 1975;Roy et al, 1986;di Meglio et al, 1987;Chakraborty and Burmeister, 2010;O'Connell et al, 2011a). The amphibian POA has several subregions based on cell size (Northcutt and Kicliter, 1980), although the homology of these subpopulations to the mammalian POA is uncertain.…”

Section: Amphibiansmentioning

confidence: 99%

“…It contains sex steroid hormone receptors (Davis and Moore, 1996;Chakraborty and Burmeister, 2010;O'Connell et al, 2011a) and has a hodological profile similar to the mammalian VMH (Allison and Wilczynski, 1991). Given how much research has focused on the neural basis of female mate choice in anurans, it is surprising that no functional studies have been done to describe its role in female receptivity.…”

Section: Amphibiansmentioning

confidence: 99%

“…The PAG in amphibians also resides in the midbrain and contains sex steroid hormone receptors (O'Connell et al, 2011a). Furthermore, this region has a connectivity profile similar to the mammalian PAG/CG (Sánchez-Camacho et al, 2001).…”

Section: Amphibiansmentioning

confidence: 99%

“…Lesions of the entire septal region in female gray tree frogs lead to a deficit in phonotaxis response (Walkowiak et al, 1999). However, steroid hormone receptors have been indentified in this region in frogs and newts (Davis and Moore, 1998;Chakraborty and Burmeister, 2010;O'Connell et al, 2011a), suggesting that sex steroid hormones could potentially modulate behavior through action in this nucleus.…”

Section: Amphibiansmentioning

confidence: 99%

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The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

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873

879

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All animals evaluate the salience of external stimuli and integrate them with internal physiological information into adaptive behavior. Natural and sexual selection impinge on these processes, yet our understanding of behavioral decision-making mechanisms and their evolution is still very limited. Insights from mammals indicate that two neural circuits are of crucial importance in this context: the social behavior network and the mesolimbic reward system. Here we review evidence from neurochemical, tract-tracing, developmental, and functional lesion/stimulation studies that delineates homology relationships for most of the nodes of these two circuits across the five major vertebrate lineages: mammals, birds, reptiles, amphibians, and teleost fish. We provide for the first time a comprehensive comparative analysis of the two neural circuits and conclude that they were already present in early vertebrates. We also propose that these circuits form a larger social decision-making (SDM) network that regulates adaptive behavior. Our synthesis thus provides an important foundation for understanding the evolution of the neural mechanisms underlying reward processing and behavioral regulation. J. Comp. Neurol. 519:3599-3639, 2011. INDEXING TERMS: social behavior; comparative neuroanatomy; amphibian; reptile; bird; teleost; reward system; social behavior network; limbic system; neural circuitsThroughout their lives, all animals constantly face situations that provide either challenges (e.g., aggression, predation) or opportunities (e.g., reproduction, foraging, habitat selection) (for a detailed review, see O'Connell and Hofmann, 2011). In all cases, environmental cues are processed by sensory systems into a meaningful biological signal while internal physiological cues (e.g., condition, maturity) and prior experience are integrated at the same time. This process usually results in behavioral actions that are adaptive, i.e., beneficial to the animal. To accomplish this, an animal's nervous system must evaluate the salience of a stimulus and elicit a context-appropriate behavioral response. Despite tremendous progress in understanding the ecology and evolution of social behavior (Lorenz, 1952;Tinbergen, 1963;Lehrman, 1965;von Frisch, 1967;Krebs and Davies, 1993;Stephens, 2008), it is less understood where in the brain these decisions (e.g., about mate choice or territory defense) are made and how these brain circuits have arisen over the course of vertebrate evolution.Recent research has begun to decipher the neural basis of social decision-making. In mammals in particular, the neural circuits that evaluate stimulus salience and/or regulate social behavior have been uncovered to some degree: the mesolimbic reward system and social behavior network (Fig. 1). It is becoming increasingly clear that the reward system (including but not limited to the midbrain dopaminergic system) is the neural circuit where the salience of an external stimulus is evaluated (Deco and Rolls, 2005;Wickens et al., 2007), as appetitive beh...

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Section: Amphibiansmentioning

confidence: 99%

Section: Amphibiansmentioning

confidence: 99%

Section: Amphibiansmentioning

confidence: 99%

Section: Amphibiansmentioning

confidence: 99%

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The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

O’Connell

Hofmann

2011

J of Comparative Neurology

Self Cite

873

879

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“…We followed the nomenclature of O'Connell et al (2011O'Connell et al ( , 2010. egr-1 was measured in brain regions that are known to receive significant auditory input as well as those that are part of the anuran social behavior network (Newman, 1999;O'Connell et al, 2010): the auditory midbrain ( principal and laminar nuclei of the torus semicircularis), parts of the thalamus that receive ascending auditory input ( posterior, central and anterior thalamic nuclei) and parts of the limbic forebrain that either receive auditory input and/or are directly implicated in modulating phonotaxis ( preoptic area, striatum, lateral septum, dorsal part of the medial pallium and nucleus accumbens).…”

Section: Quantification Of Egr-1 Expressionmentioning

confidence: 99%

Effects of estradiol on neural responses to social signals in female túngara frogs

Chakraborty

Burmeister

2015

Journal of Experimental Biology

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Estradiol plays an important role in mediating changes in female sexual behavior across reproductive cycles. In the tuńgara frog [Physalaemus (=Engystomops) pustulosus], the relationship between gonadal activity and female sexual behavior, as expressed by phonotaxis, is mediated primarily by estradiol. Estradiol receptors are expressed in auditory and motivational brain areas and the hormone could serve as an important modulator of neural responses to conspecific calls. To better understand how estradiol modifies neural responses to conspecific social signals, we manipulated estradiol levels and measured expression of the immediate early gene egr-1 in the auditory midbrain, thalamus and limbic forebrain in response to conspecific or heterospecific calls. We found that estradiol and conspecific calls increased egr-1 expression in the auditory midbrain and limbic forebrain, but in the thalamus, only conspecific calls were effective. In the preoptic area, estradiol enhanced the effect of the conspecific call on egr-1 expression, suggesting that the preoptic area could act as a hormonal gatekeeper to phonotaxis. Overall, the results suggest that estradiol has broad influences on the neural circuit involved in female reproduction, particularly those implicated in phonotaxis.

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Effects of Steroid Hormones on Hearing and Communication in Frogs

Wilczynski

Burmeister²

2016

Hearing and Hormones

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Neural distribution of the nuclear progesterone receptor in the túngara frog, Physalaemus pustulosus

Cited by 16 publications

References 86 publications

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

The Vertebrate mesolimbic reward system and social behavior network: A comparative synthesis

Effects of estradiol on neural responses to social signals in female túngara frogs

Effects of Steroid Hormones on Hearing and Communication in Frogs

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