Neural dynamics during repetitive visual stimulation

Tsoneva, Tsvetomira; Garcia-Molina, Gary; Desain, Peter

doi:10.1088/1741-2560/12/6/066017

Cited by 20 publications

(21 citation statements)

References 47 publications

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“…Crevier and Meister reported subharmonic components for stimulus frequencies between 30-70 Hz [13]. Tsoneva et al have observed subharmonic generation in the 40-60 Hz stimulus frequency range [14]. In addition to these studies, in our previous work, our results showed subharmonic generation for the stimulus range of 15-42 Hz [15].…”

Section: Introductionsupporting

confidence: 79%

“…Period doubling in SSVEP experiments have been consistently observed across different studies [2,6,[13][14][15]. The occurrence of period doubling has been speculated to be by 'entrainment' of intrinsic brain oscillations to half of the external stimulation frequency [14,16,17,29]. Tsoneva et al define the term entrainment as the synchronization of naturally ongoing oscillations to an external force [14].…”

Section: Discussionmentioning

confidence: 98%

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A model based investigation of the period doubling behavior in human steady-state visual evoked potentials

Tuncel¹,

Başaklar²,

Ider³

2019

Biomed. Phys. Eng. Express

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Objective. This study aims at investigating the potential mechanism of period doubling (PD) (subharmonic generation) in human steady-state visual evoked potentials (SSVEPs) by using a mathematical model. Approach. Robinson's Corticothalamic Model, which includes three main neuronal populations (cortical, thalamic reticular, and thalamic relay neurons) was employed. SSVEP experiments were simulated using this model and dependence of PD behavior in relation to the values of model parameters was investigated. The feedback loop in the model that is responsible for the generation of subharmonic components was thus identified, and this loop was isolated from the rest of the model and analyzed with a describing function approach. Main Results. It has been found in general, for a wide range of parameter values, that if the excitation frequency or half of it is close to the native oscillation frequency of the system, the native oscillation ceases to exist and oscillations at either the excitation frequency or half of it are observed. This observation is in line with the experimental findings except for some discrepancies which are also discussed. The intrathalamic feedback loop is identified to be the potential source of subharmonic oscillations. When isolated from the rest of the model and simulated by itself, it has been found that this feedback loop can show a resonance phenomenon at the subharmonic frequency. By deriving a set of equations based on the necessary conditions for a resonance phenomenon, a semi-analytical method was developed by which one can predict the existence of subharmonic generation for a given set of parameters and stimulus frequency. Significance. This study is the first model-based investigation of the mechanism of subharmonic oscillations. The proposed semianalytical method can replace extensive time and memory consuming parameter sweep studies.

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Section: Introductionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 98%

A model based investigation of the period doubling behavior in human steady-state visual evoked potentials

Tuncel¹,

Başaklar²,

Ider³

2019

Biomed. Phys. Eng. Express

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“…They have used square wave light source with 2 Hz steps, excluding 50 Hz. They reported subharmonic responses throughout this stimulus frequency range along with valuable spatiotemporal information regarding SSVEPs [8].…”

Section: Introductionmentioning

confidence: 94%

“…SSVEPs have been widely used in engineering applications such as brain-computer interfaces (BCIs) [3] and cognitive and clinical research [4,5], however, there is not a precise explanation about their mechanism of generation. In particular, some nonlinear resonance phenomena of SSVEPs, which have been observed by several researchers [6][7][8][9], need to be better understood. These phenomena are characterized by brain responses at harmonic and subharmonic frequencies (period doubling (PD) behavior) as well as the response to the stimulus frequency.…”

Section: Introductionmentioning

confidence: 99%

Period doubling behavior in human steady state visual evoked potentials

Tuncel

Başaklar

Ider

2018

Biomed. Phys. Eng. Express

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Objective. Previous human steady state visual evoked potential (SSVEP) experiments have yielded different results regarding the range of stimulus frequencies in which period doubling (PD) behavior is observed. This study aims at obtaining experimental and statistical data regarding the frequency range of PD generation and also investigates other characteristics of PD. Approach. In two sets of experiments, seven subjects were presented a sinusoidal flickering light stimulus with frequencies varying from 15 to 42 Hz. To observe the short term variations in PD generation, another set of 5 successive experiments were performed on five subjects with 10 min breaks in between. To obtain the SSVEP responses, filtering, signal averaging and power spectral density (PSD) estimation were applied to the recorded electroencephalogram. From the PSD estimates, subharmonic occurrence rates were calculated for each experiment and were used along with ANOVA for interpreting the outcomes of the short term repeatability experiments. Main results. Although fundamental (excitation frequency) and second harmonic components appear in almost all SSVEP spectra, there is considerable inter-subject and intra-subject variability regarding PD occurrence. PD occurs for all stimulus frequencies from 15 to 42 Hz when all subjects are considered together. Furthermore, the statistical analyses of short term repeatability experiments suggest that in the short term, PD generation is consistent when all frequencies are considered together but for a single frequency significant short term differences occur. There also is considerable variation in the ratio of subharmonic amplitude to fundamental amplitude across different frequencies for a given subject. Significance. Important results and statistical data are obtained regarding PD generation. Our results indicate that modeling studies should attempt to generate PD for a broader range of stimulus frequencies. It is argued that SSVEP based braincomputer interface applications would likely benefit from the utilization of subharmonics in classification.

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“…This phenomenon was reasonable due to the relations between the right-handed driven motor task and the increased excitability over the left primary motor cortex. The locally decreased IAB was probably associated with the excitability enhancement of motor cortex [12] while the increased IAB could be caused by the excitability inhibition of other regions, which resembled the 'focal ERD/surround ERS' phenomenon [13,14]. It was interesting that HIAB and LIAB showed opposite change in all channels and the locally decreased IAB might result from obviously the decrease of HIAB and the increase of LIAB in all brain regions.…”

Section: Discussionmentioning

confidence: 95%

Time course of EEG activities in continuous tracking task: a pilot study

Yang¹,

Shen²,

Nan

et al. 2017

Computer Assisted Surgery

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Motor learning is crucial to surgical skills enhancement, but its neural mechanism has been investigated only using some simple tasks with limited motor involvement. This study aimed to gain more understanding of the neural dynamics during motor learning by investigating the time course of electroencephalogram (EEG) activities in the continuous tracking task that involves more motor components. One participant performed 16 trials of the continuous tracking task on Day1 and Day2 respectively. The 16-channel EEG signals were recorded and analyzed in both the resting and active states. Results showed that the tracking performance improved from Day1 to Day2. Regarding the EEG, it was found that the relative amplitude in the individual alpha band (IAB) decreased locally over primary motor cortex from the resting state to the active state on both days, and this reduction was more focused on the left primary motor cortex on Day2 compared to Day1. Moreover, in the active state the alpha coherence between central and frontal areas also significantly increased from Day1 to Day2. Time course of alpha activities may explain the tracking performance enhancement from Day1 to Day2. Future work will include more participants to extend the validity of current results.

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Neural dynamics during repetitive visual stimulation

Cited by 20 publications

References 47 publications

A model based investigation of the period doubling behavior in human steady-state visual evoked potentials

A model based investigation of the period doubling behavior in human steady-state visual evoked potentials

Period doubling behavior in human steady state visual evoked potentials

Time course of EEG activities in continuous tracking task: a pilot study

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