Neural dysfunction following respiratory viral infection as a cause of chronic cough hypersensitivity

Undem, Bradley J.; Zaccone, Eric J.; McGarvey, Lorcan; Mazzone, Stuart B.

doi:10.1016/j.pupt.2015.06.006

Cited by 37 publications

(27 citation statements)

References 60 publications

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“…The similarities between, somatic and airway afferent neurophysiology supports the notion that common mechanisms may underlie the development of pain and cough hypersensitivities (Mazzone et al, 2009, Ji, 2015, Undem et al, 2015, Ando et al, 2016. Indeed, chronic pain and cough are characterised by common phenotypes that relate to underlying inflammatory and/or neuropathic processes (Latremoliere and Woolf, 2009, Chung et al, 2013, Ji, 2015.…”

Section: Accepted Manuscriptmentioning

confidence: 79%

“…Such a framework can be laid down by looking at other nociceptive systems where the mechanisms of central neural plasticity have been extensively investigated. Perhaps the best example of this is in the chronic pain field where the inflammatory and neuropathic mechanisms leading to changes in central circuit connectivity, neuronal excitability and gene expression are well described (Latremoliere and Woolf, 2009, Undem et al, 2015, Bettini and Moore, 2016.…”

Section: Can Airway Afferent Circuits In the Brain Be Altered In Disementioning

confidence: 99%

“…This sensitisation is restricted to a localised area of damage and drives hypersensitivities at the injury site (Latremoliere andWoolf, 2009, Bettini andMoore, 2016). The evidence for peripheral sensitisation in chronic cough has been reviewed elsewhere and won't be repeated here (Undem et al, 2015;Zaccone and Undem, 2016;Mazzone and Undem, 2016). (Latremoliere andWoolf, 2009, Liang et al, 2016).…”

Section: Accepted Manuscriptmentioning

confidence: 99%

“…With respect to cough, studies have shown that airway afferent second order neurons in the brainstem can similarly become hyperexcitable (Mutoh et al, 2000, Mazzone and Canning, 2002, Mazzone et al, 2005, Kline et al, 2007, Sekizawa et al, 2008, Undem et al, 2015. More specifically, exposure of the airways to environmental pollutants,…”

Section: Accepted Manuscriptmentioning

confidence: 99%

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Central mechanisms of airway sensation and cough hypersensitivity

Driessen

McGovern

Narula

et al. 2017

Pulmonary Pharmacology & Therapeutics

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The airway sensory nervous system is composed of two anatomically distinct processing pathways that allow for the production of respiratory reflexes and voluntary evoked respiratory behaviours in response to sensing an airway irritation. Disordered sensory processing is a hallmark feature of many pulmonary disorders and results in the development of cough hypersensitivity syndrome, characterised by chronic cough and a persistent urge-to-cough in affected individuals. However, the mechanism underpinning how the airway sensory circuits become disordered, especially at the level of the central nervous system, is not well understood. In this mini-review we present well-defined mechanisms that lead to the development of chronic pain as a framework to explore the evidence that cough disorders may manifest due to neuroplasticity and sensitisation of important components of the airway sensory circuitry in the brain. We highlight recent discoveries of how airway sensory processing occurs in the brain in health and disease and additionally suggest areas where gaps exist in our current knowledge on the topic, with the goal of providing a better understanding of how airway circuits become dysfunctional in disease. This may in turn help identify novel therapeutic targets for restoring normal airway sensory processing and alleviating excessive cough.

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Section: Accepted Manuscriptmentioning

confidence: 79%

Section: Can Airway Afferent Circuits In the Brain Be Altered In Disementioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Accepted Manuscriptmentioning

confidence: 99%

See 2 more Smart Citations

Central mechanisms of airway sensation and cough hypersensitivity

Driessen

McGovern

Narula

et al. 2017

Pulmonary Pharmacology & Therapeutics

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“…Though infectious causes of cough generally remain unresolved, bacterial pathogens including Bordetella pertussis, Bordetella parapertussis, Mycoplasma pneumonia and Chlamydophila (Chlamydia) pneumoniae are most frequently identified [29]. Fungi are also implicated, triggering cough hypersensitivity via activation of allergic responses, while viral causes of neural dysfunction following respiratory infection have been linked to aberrant cough sensitisation that persists beyond initial infection [30,31]. The primary bacterial species identified in bronchiectasis include Haemophilus influenzae and Pseudomonas aeruginosa and their detection has a major bearing on antimicrobial treatment choices [32].…”

Section: The Inter-relationship Between Cough and Bronchiectasismentioning

confidence: 99%

Bronchiectasis and cough: An old relationship in need of renewed attention

Aogáin

Chotirmall

2019

Pulmonary Pharmacology & Therapeutics

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A B S T R A C TBronchiectasis is an increasingly recognised respiratory condition with limited therapeutic options and a complex spectrum of clinical manifestations that invariably includes chronic cough. As the primary presentation of bronchiectasis in most cases, chronic cough and its mechanistic underpinnings are of central importance but remain poorly understood in this setting. Bronchiectasis is also increasingly identified as an underlying cause of chronic cough highlighting the interrelationship between the two conditions that share overlapping clinical features. Several therapeutic approaches have illustrated positive effects on bronchiectasis-associated cough, however, more focused treatment of heterogeneous cough subtypes may yield better outcomes for patients. A current challenge is the identification of bronchiectasis and cough endophenotypes that may allow improved patient stratification and more targeted therapeutic matching of the right treatment to the right patient. Here we discuss the complex disease phenotypes of bronchiectasis and their interrelationship with cough while considering current and emerging treatment options. We discuss some key cough promoters in bronchiectasis including infection, allergy and immune dysfunction.

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Progress and treatment of “long COVID” in non‐hospitalized patients: A single‐center retrospective cohort study

Ono

Arita

Takayama

et al. 2023

Traditional & Kampo Medicine

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Background“Long COVID” or “post‐COVID conditions” describes prolonged symptoms after the acute phase of coronavirus disease 2019 (COVID‐19). However, there is a paucity of published reports on its treatment.MethodThis retrospective cohort study included adult, non‐hospitalized patients with COVID‐19 symptoms at least one month after the onset who had been examined at the isolation facility in Miyagi prefecture between October 2020 and September 2021.ResultsIn total, 70 patients with a median age of 46 (21–69) years were included, and 37 were women (52.9%). The median time from onset to the end of treatment was 46 (28–396) days. Thirty‐eight patients (53.5%) showed improvement in all symptoms, while four (5.7%) did not recover within the study period. The symptoms at six months with high residual rates were dizziness (33.3%), fatigue (14.3%), myalgia (14.3%), abdominal discomfort (14.3%), and taste dysfunction (11.8%). For treatment of prolonged symptoms, formulae of Kampo medicine (Japanese traditional medicine) were used alone or in combination with Western medications in 76%, 66%, 53%, and 66% of patients at 1–2 months, 2–3 months, 3–6 months, and over 6 months respectively. Kampo formulae with anti‐inflammatory effects were used in the early period; however, tonifying formulae and blood stasis‐resolving formulae were used in the late period.ConclusionNon‐hospitalized patients with COVID‐19 may suffer from persistent symptoms after the acute phase of infection. For the management of long COVID, a comprehensive and holistic approach is needed. Kampo medicine should be considered as a treatment option for long COVID.

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Neural dysfunction following respiratory viral infection as a cause of chronic cough hypersensitivity

Cited by 37 publications

References 60 publications

Central mechanisms of airway sensation and cough hypersensitivity

Central mechanisms of airway sensation and cough hypersensitivity

Bronchiectasis and cough: An old relationship in need of renewed attention

Progress and treatment of “long COVID” in non‐hospitalized patients: A single‐center retrospective cohort study

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