Neural ECM in addiction, schizophrenia, and mood disorder

Lubbers, Bart R; Smit, August B.; Spijker, Sabine; Oever, Michel C. van den

doi:10.1016/b978-0-444-63486-3.00012-8

Cited by 54 publications

(44 citation statements)

References 119 publications

(192 reference statements)

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“…Genetic alterations or environmental stimuli that affect the composition of the ECM are thought to contribute to neurodegenerative and psychiatric disorders, including drug addiction (Lubbers et al, 2014a;Vegh et al, 2014). The ECM consists mainly of deposits of hyaluronic acid, glycoproteins and proteoglycans in the extracellular space (Dityatev and Schachner, 2003).…”

Section: Introductionmentioning

confidence: 99%

The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference

Lubbers

Matos

Horn

et al. 2015

Neuropsychopharmacol

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Cocaine-associated environmental cues sustain relapse vulnerability by reactivating long-lasting memories of cocaine reward. During periods of abstinence, responding to cocaine cues can time-dependently intensify a phenomenon referred to as 'incubation of cocaine craving'. Here, we investigated the role of the extracellular matrix protein brevican in recent (1 day after training) and remote (3 weeks after training) expression of cocaine conditioned place preference (CPP). Wild-type and Brevican heterozygous knock-out mice, which express brevican at~50% of wild-type levels, received three cocaine-context pairings using a relatively low dose of cocaine (5 mg/kg). In a drug-free CPP test, heterozygous mice showed enhanced preference for the cocaine-associated context at the remote time point compared with the recent time point. This progressive increase was not observed in wild-type mice and it did not generalize to contextualfear memory. Virally mediated overexpression of brevican levels in the hippocampus, but not medial prefrontal cortex, of heterozygous mice prevented the progressive increase in cocaine CPP, but only when overexpression was induced before conditioning. Postconditioning overexpression of brevican did not affect remote cocaine CPP, suggesting that brevican limited the increase in remote CPP by altering neuro-adaptive mechanisms during cocaine conditioning. We provide causal evidence that hippocampal brevican levels control time-dependent enhancement of cocaine CPP during abstinence, pointing to a novel substrate that regulates incubation of responding to cocaine-associated cues.

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Section: Introductionmentioning

confidence: 99%

The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference

Lubbers

Matos

Horn

et al. 2015

Neuropsychopharmacol

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“…This gene family, which encodes a number of secreted extracellular matrix-associated proteins expressed in the brain (Malik et al, 2015), represents an interesting candidate for effects on PP risk given: a) its known involvement in female reproductive function (Winterhager and Gellhaus, 2014), b) its dynamic brain expression throughout pregnancy and the puerperium (Ray et al, 2015), c) its modulation of Notch and Wnt signalling pathways (Winterhager and Gellhaus, 2014) that are disrupted in bipolar disorder (Pedroso et al, 2012) and cases of postpartum psychiatric disturbance (Pantoni et al, 2005) and d) the known role of extracellular-matrix dysfunction in the pathophysiology of mood disorders (Lubbers et al, 2014). Additionally, Ccn gene expression may be altered by the administration of psychotomimetic agents (Sakuma et al, 2015), by social stress (Stankiewicz et al, 2015), and by small molecules including cytokines and serotonin (Chen et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis

Humby

Cross

Messer

et al. 2016

Psychoneuroendocrinology

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“…The extracellular matrix (ECM) is a structural element that plays a prominent role in neurodevelopment and maturation of neural circuits (Lubbers et al 2014) as it can influence cell adhesion, survival, proliferation, migration, and differentiation (Tzu and Marinkovich 2008). Interactions between the ECM protein laminin and integrin receptors represent a specific ECM-cell interaction that regulates many key aspects of neurodevelopment (Belvindrah et al 2007; Graus-Porta et al 2001; Lubbers et al 2014; Warren et al 2012).…”

Section: Evaluation Of the Scientific Confidence Of The Existing Datamentioning

confidence: 99%

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

et al. 2017

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The Adverse Outcome Pathway (AOP) concept has recently been proposed to support a paradigm shift in regulatory toxicology testing and risk assessment. This concept is similar to the Mode of Action (MOA), in that it describes a sequence of measurable key events triggered by a molecular initiating event in which a stressor interacts with a biological target. The resulting cascade of key events includes molecular, cellular, structural and functional changes in biological systems, resulting in a measurable adverse outcome. Thereby, an AOP ideally provides information relevant to chemical structure-activity relationships as a basis for predicting effects of structurally similar compounds. AOPs could potentially also form the basis for qualitative and quantitative predictive modeling of the human adverse outcome resulting from molecular initiating or other key events for which higher-throughput testing methods are available or can be developed. A variety of cellular and molecular processes are known to be critical for normal function of the central (CNS) and peripheral nervous systems (PNS). Because of the biological and functional complexity of the CNS and PNS, it has been challenging to establish causative links and quantitative relationships between key events that comprise the pathways leading from chemical exposure to an adverse outcome in the nervous system. Following introduction of the principles of MOA and AOPs, examples of potential or putative adverse outcome pathways specific for developmental or adult neurotoxicity are summarized and aspects of their assessment considered. Their possible application in developing mechanistically informed Integrated Approaches to Testing and Assessment (IATA) is also discussed.

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Neural ECM in addiction, schizophrenia, and mood disorder

Cited by 54 publications

References 119 publications

The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference

The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference

A pharmacological mouse model suggests a novel risk pathway for postpartum psychosis

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

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