Neural ECM mimetics

Estrada, Veronica; Tekinay, Ayşe B.; Müller, Hans

doi:10.1016/b978-0-444-63486-3.00016-5

Cited by 21 publications

(16 citation statements)

References 125 publications

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“…A collagen-based scaffold that incorporated the soluble Nogo receptor improved recovery in a model of penetrating brain injury (Elias & Spector, 2015). Based on these results, a promising area is the potential uses of ECM and ECM-derived peptides that improve neuronal regeneration and functional recovery (Estrada, Tekinay, & Muller, 2014).…”

Section: Ec M M Odu L a Ti On As A P Oten Ti A L Th Er A P Y F Or Tbimentioning

confidence: 99%

Extracellular matrix and traumatic brain injury

George

Geller

2018

J of Neuroscience Research

102

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The Brain Extracellular Matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following Traumatic Brain Injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment.

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Section: Ec M M Odu L a Ti On As A P Oten Ti A L Th Er A P Y F Or Tbimentioning

confidence: 99%

Extracellular matrix and traumatic brain injury

George

Geller

2018

J of Neuroscience Research

102

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“…In the stripe assay, the CSPG-positive stripes may remain the less preferred substrate even after Reelin application. Future studies might address this by using neural ECM scaffolds to more closely mimic the 3D extracellular environment (Estrada et al, 2014). Because reeler dendrites avoid the MZ, and the stripe assay data suggested a Reelin-CSPG interaction affecting dendrites, we examined dendritic growth ratios in wild-type (with Reelin) and reeler (without Reelin) cortical explants treated with and without chondroitinase.…”

Section: Discussionmentioning

confidence: 99%

Reelin Counteracts Chondroitin Sulfate Proteoglycan-Mediated Cortical Dendrite Growth Inhibition

Zluhan

Enck

Matthews

et al. 2020

eNeuro

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Disruptions in neuronal dendrite development alter brain circuitry and are associated with debilitating neurological disorders. Nascent apical dendrites of cortical excitatory neurons project into the marginal zone (MZ), a cell-sparse layer characterized by intense chondroitin sulfate proteoglycan (CSPG) expression. Paradoxically, CSPGs are known to broadly inhibit neurite growth and regeneration. This raises the possibility that the growing apical dendrite is Significance Statement Appropriate dendritic development is essential for normal neuronal function throughout life. The area where most cortical dendrites initially project (the marginal zone) is cell sparse but highly enriched in chondroitin sulfate proteoglycans (CSPGs). While CSPGs are known to inhibit axonal outgrowth, their impact on dendritic growth is unclear. This study demonstrates that the growth of the apical dendrite is also inhibited by CSPGs. However, this inhibitory effect can be reversed by chondroitinase treatment and by activation of the Reelin signaling pathway. Disruptions in Reelin signaling cause intellectual disability and have been linked to autism. Thus, these findings identify a context in which Reelin signaling operates and provide insight into the underlying mechanism of neurodevelopmental disorders.

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“…Rajesh et al thought the biological processes of glioma were closely correlated with the remolding of ECM and the proteolysis of ECM participated in the invasion. While Estrada et al hold that ECM served as a growth‐promoting substrate for the neuron in the central nervous system. Meanwhile, ECM can activate the growth factor, regulate proliferation, and promote invasion in brain tumors .…”

Section: Discussionmentioning

confidence: 99%

Identification of genes related to low‐grade glioma progression and prognosis based on integrated transcriptome analysis

Jiang

Guo

et al. 2019

J of Cellular Biochemistry

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Glioma is one of the most common types of human brain tumor, with high mortality in high-grade gliomas (HGG). Low-grade gliomas (LGG) can progress into HGG, leading to poor prognosis. However, it is unclear what factors affect the progression of LGG to HGG. This study aims to explore the function of the crosstalk genes on the progression and prognosis of LGG using bioinformatics analysis. Integrated transcriptome analysis was used to screen differentially expressed genes (DEGs). Then, gene ontology (GO) function enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were performed to investigate the association between DEGs and gene functions and pathways by ClusterProfiler package and ClueGO plug-in. Protein-protein interaction (PPI) network analysis was applied to explore the connection between genes and biological processes. Subsequently, the gene clusters were analyzed using the Centiscape and molecular complex detection (MCODE) plug-in in Cytoscape software, where the crosstalk genes were identified for further study. Ultimately, the UALCAN website and Gene Expression Profiling Interactive Analysis (GEPIA) website were performed to visualize the expression levels and survival curves of genes, respectively. There were 74DEGs identified in glioma, including 55 upregulated genes and 19 downregulated genes, which mainly were enriched in extracellular matrix (ECM)receptor interaction, focal adhesion, PI3K-Akt signaling pathway, and so on. Then, six crosstalk genes were selected, including COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, and COL5A2 genes. Overall survival (OS) analysis of crosstalk genes was conducted on the GEPIA website. High expression levels of crosstalk genes were closely related to the low survival rate of patients withLGG. The overexpressed crosstalk genes, such as COL1A1, COL1A2, COL3A1, COL4A1, COL4A2, and COL5A2 may participate in the progression and poor prognosis of LGG through the ECM-receptor interaction pathway. K E Y W O R D S bioinformatics, crosstalk genes, glioma, prognosis, progression Yongcan Guo and Hualin Tao contributed equally to this study.Glioma is the most common primary tumor of the central nervous system, 1 diagnosed based on pathological grade and molecular subtype. And gliomas are classified into grades I to IV by World Health Organization (WHO), including low-grade (WHO grades I-II) and high-grade (WHO grades III-IV) gliomas. 2 High-grade gliomas (HGG) have a high mortality rate and low five-year survival rate with less than 10%. 3 The effect of radiotherapy and chemotherapy is not obvious for HGG, leading to the median survival time of 14 to 17 months, 4 less than the low-grade glioma (LGG), of which the average survival time is approximately 10 years. By contrast, in case the LGG progress into HGG, the mortality rate will increase. 5 Therefore, it is necessary to explore the factors that have an influence on the progression of LGG to HGG, aiming at slowing down the progression and extending survival time of patients with LGG. In recent years, most ...

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Neural ECM mimetics

Cited by 21 publications

References 125 publications

Extracellular matrix and traumatic brain injury

Extracellular matrix and traumatic brain injury

Reelin Counteracts Chondroitin Sulfate Proteoglycan-Mediated Cortical Dendrite Growth Inhibition

Identification of genes related to low‐grade glioma progression and prognosis based on integrated transcriptome analysis

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