Neural function underlying reward expectancy and attainment in adolescents with diverse psychiatric symptoms

Liu, Qi; Stern, Emily; Xu, Junqian; Kim, Joo Won; Pick, Danielle; Alonso, Carmen; Gabbay, Vilma

doi:10.1016/j.nicl.2022.103258

Cited by 6 publications

(3 citation statements)

References 56 publications

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“…7). This aligns with previous resting-state studies showing disrupted functional connectivity within reward-related brain networks (including amygdala, hippocampus, and prefrontal cortex) in anxiety disorders [55][56][57][58] .…”

Section: Discussionsupporting

confidence: 91%

Reduced Reverse Replay in Anxious Individuals Impairs Reward Prediction

Luo

Dolan

et al. 2023

Preprint

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Anxiety traits can manifest as a tendency to overlook positive information, impacting memory and decision-making. Using EEG-based neural decoding, we examined future reward prediction in participants with varying levels of trait anxiety. In a resting period, following value learning, we found an increase in reverse replay for a task sequence that led to reward. This reward-related replay was significantly reduced within individuals exhibiting higher trait anxiety. Furthermore, this reduction correlated with a distorted neural representation of the reward-predictive sequence, an effect mirrored behaviorally in an attenuated preference for stimuli within the same sequence. These findings indicate that higher trait anxiety may impede formation of reward-predictive representations by reducing offline replay during rest. More broadly, our demonstration of sequential replay using EEG enables examination of offline learning and memory consolidation in wider populations, particularly those with psychopathology.

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Section: Discussionsupporting

confidence: 91%

Reduced Reverse Replay in Anxious Individuals Impairs Reward Prediction

Luo

Dolan

et al. 2023

Preprint

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“…However, adolescent depression varies considerably in course and severity wherein some depressed youth fully recover, while others will have a more severe and progressive illness into adulthood, despite treatment (Birmaher et al, 2000;Costello, Mustillo, Erkanli, Keeler, & Angold, 2003;Curry et al, 2011;Emslie et al, 2015;Emslie et al, 1998;McCauley et al, 1993). Our group and others have showed that anhedonia and reward dysfunction predict worse outcomes among depressed adolescents (Bennik, Nederhof, Ormel, & Oldehinkel, 2014;Gabbay et al, 2015;Liu et al, 2022;McMakin et al, 2012). However, there are no reliable biological predictors of illness trajectory for adolescent depression at present.…”

Section: Introductionmentioning

confidence: 86%

C-reactive protein does not predict future depression onset in adolescents: preliminary findings from a longitudinal study

Schwartz,

Roske,

Liu

et al. 2023

Preprint

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Introduction: Neuroinflammatory processes have been extensively implicated in the underlying neurobiology of numerous neuropsychiatric disorders. Elevated C-reactive protein (CRP), an indicator of non-specific inflammation commonly utilized in clinical practice, has been associated with depression in adults. In adolescents, our group previously found CRP to be associated with altered neural reward function but not with mood and anxiety symptoms assessed cross-sectionally. We hypothesized that the distinct CRP findings in adolescent vs. adult depression may be due to chronicity, with neuroinflammatory effects on psychiatric disorders gradually accumulating over time. Here, we conducted a longitudinal study to evaluate if CRP levels predicted future onset or progression of depression in adolescents.Methods: Participants were 53 adolescents (ages 14.74 ± 1.92, 35 female), 40 with psychiatric symptoms and 13 healthy controls. At baseline, participants completed semi-structured diagnostic evaluations; dimensional assessments for anxiety, depression, anhedonia, and suicidality severity; and bloodwork to quantify CRP levels. Clinical assessments were repeated at longitudinal follow-up after approximately 1.5 years. Spearman's correlation between CRP levels and follow-up symptom severity were controlled for BMI, age, sex, and follow-up interval and considered significant at the two-tailed, Bonferroni-adjustedp< 0.05 level.Results: After correction for multiple comparisons, no relationships were identified between baseline CRP levels and follow-up symptom severity.Conclusion: CRP levels were not significantly associated with future psychiatric symptoms in adolescents in this preliminary analysis. This may suggest that CRP is not a useful biomarker for adolescent depression and anxiety. However, future longitudinal studies with larger sample sizes and incorporating additional indicators of neuroinflammation are needed.Keywords: CRP, Depression, Anxiety, Anhedonia, Inflammation, Adolescent, Longitudinal

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“…Building and expanding upon the above observations, here we sought to examine the relationships between subconstructs of family dysfunction and symptomatology in a diverse sample of adolescents who presented predominantly with mood and anxiety symptoms. We speci cally assessed levels of anhedonia, depression, and anxiety as they often co-manifest clinically but likely represent distinct underlying mechanisms (25,(28)(29)(30)(31)(32)(33). We used the McMaster Family Assessment Device (FAD; (34)) to systemically evaluate family functioning by capturing seven complementary family domains.…”

Section: Introductionmentioning

confidence: 99%

Depression, Anxiety, and Anhedonia as Correlates of Distinct Family Functioning Domains among Adolescents

Nguyen,

Chance,

Chase

et al. 2023

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Background The bi-directional relationships between family dynamics and psychopathology have been documented, yet how aspects of family functioning relate to specific symptoms remains elusive. Such work is important in adolescence as it represents a vulnerable developmental period when psychiatric symptoms often emerge. Critically, most research on family functioning has focused on categorical clinical diagnoses and has not accounted for the inter-individual variability of symptom severity. Therefore, we aimed to study the associations between well-validated domains of family functioning and depression, anxiety, and anhedonia in youth using a dimensional approach. Methods We comprehensively evaluated 59 adolescents with diverse mood and anxiety symptoms and 17 controls with semi-structured diagnostic interviews and self-reported measures for depression, anxiety, and anticipatory and consummatory anhedonia. Adolescents’ perception of seven aspects of family life was assessed with the McMaster Family Assessment Device (FAD). Following bivariate assessments of associations between FAD subscales and symptom measures, linear regression models were employed to further investigate their relationships accounting for variations in age, sex, race, and ethnicity. Results were corrected for multiple comparisons. Results As hypothesized, more severe depression was implicated across most family domains, including Problem Solving, Communication, Roles, Affective Responsiveness, and General Functioning. Elevated anxiety was associated with worse family Problem Solving, Roles, and General Functioning. Interestingly, anhedonia showed no relationship with family domains following adjustment for multiple comparisons and depression severity, suggesting a different etiological pathway. Conclusions Our findings further support the intertwined relationships between family factors and adolescent mood processes and the need for specialized interventions addressing multiple family dimensions simultaneously.

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Neural function underlying reward expectancy and attainment in adolescents with diverse psychiatric symptoms

Cited by 6 publications

References 56 publications

Reduced Reverse Replay in Anxious Individuals Impairs Reward Prediction

Reduced Reverse Replay in Anxious Individuals Impairs Reward Prediction

C-reactive protein does not predict future depression onset in adolescents: preliminary findings from a longitudinal study

Depression, Anxiety, and Anhedonia as Correlates of Distinct Family Functioning Domains among Adolescents

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