Neural generators of tibial nerve P30 somatosensory evoked potential studied in patients with a focal lesion of the cervicomedullary junction

Tinazzi, Michèle; Zanette, Giampietro; Bonato, Claudio; Manganotti, Paolo; Polo, A.; Fiaschi, Antonio; Mauguı̀ere, François

doi:10.1002/(sici)1097-4598(199612)19:12<1538::aid-mus3>3.0.co;2-b

Cited by 14 publications

(3 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data show a significant increase in amplitude of the vertex-ipsilateral central P37-N50 response in patients with dystonia. These SEP changes occurred despite the fact that the contralateral N37 potential did not differ from the control group and were probably unrelated to central dysfunction below the dorsal column nuclei, because the P30 far-field potential, which is thought to originate close to the nucleus gracilis, 25 was normal.…”

Section: Discussionmentioning

confidence: 79%

“…The rationale for choosing the ipsilateral earlobe reference is discussed in detail in our recent study. 24 In brief, it represents the most convenient electrode reference to separately record "genuine" vertex and pre-rolandic SEPs, because in this montage subcortical P30 and N33 components, originating in the brain stem, 25 are also picked up by the earlobe and thus partially eliminated; further, while the contralateral earlobe reference detects the lat- To ensure full muscle relaxation during SEP recording, voluntary muscular activity was monitored through surface EMG recordings from the tibialis anterior and gastrocnemius muscles ipsilateral to the stimulated side.…”

Section: Sep Recordingmentioning

confidence: 99%

See 1 more Smart Citation

Evidence for an abnormal cortical sensory processing in dystonia: Selective enhancement of lower limb P37-N50 somatosensory evoked potential

et al. 1999

View full text Add to dashboard Cite

We evaluated brain stem P30, contralateral frontal N37, and the vertex‐ipsilateral central P37, N50 somatosensory evoked potentials (SEPs) obtained in response to stimulation of the tibial nerve in 10 patients with idiopathic dystonia. Results were compared with those obtained in 10 healthy subjects matched for age and sex. The amplitude of the brain stem P30 potential and of the contralateral frontal N37 response in dystonic patients was not significantly different from that recorded in normal subjects. The vertex‐ipsilateral central P37‐N50 complex, which is thought to originate in the pre‐rolandic cortex, was significantly enhanced in patients compared with the control group. These results suggest the enhancement of the vertex‐ipsilateral central P37‐N50 complex might reflect an abnormal response to somatosensory inputs of a precentral cortex which is excessively activated because of a disorder of the basal ganglia. Such inefficient sensory processing in motor areas might contribute to motor impairment in dystonia.

show abstract

Section: Discussionmentioning

confidence: 79%

Section: Sep Recordingmentioning

confidence: 99%

Evidence for an abnormal cortical sensory processing in dystonia: Selective enhancement of lower limb P37-N50 somatosensory evoked potential

et al. 1999

View full text Add to dashboard Cite

show abstract

“…Third, we had hoped to reliably record brainstem SEPs arising from the cuneate nucleus (N14) (Suzuki & Mayanagi, 1984) and gracile nucleus (N30) (Tinazzi et al, 1996), as these are targets of the post-synaptic dorsal column pathways, i.e., direct recipients of output from the spinal cord. Brainstem SEPs are typically recorded as far-field potentials between a non-cephalic reference and Fz (Mauguière et al, 1999), but can be recorded between the brainstem and a frontal channel as well (Restuccia et al, 1995; Tinazzi et al, 1995, 1996). Despite using optimal signal extraction leads here, observing brainstem potentials was not possible in all conditions, mainly due to the limited SNR of SEPs to digit stimulation, where most participants did not show brainstem potentials.…”

Section: Discussionmentioning

confidence: 99%

A multi-channel electrophysiology approach to non-invasively and precisely record human spinal cord activity

Nierula

Stephani

Kaptan

et al. 2022

Preprint

View full text Add to dashboard Cite

The spinal cord is of fundamental importance for somatosensory processing and plays a significant role in various pathologies, such as chronic pain. However, knowledge on spinal cord processing in humans is limited due to the vast technical challenges involved in its investigation via non-invasive recording approaches. Here, we aim to address these challenges by developing an electrophysiological approach — based on a high-density electrode-montage — that allows for characterizing spinal cord somatosensory evoked potentials (SEPs) and combining this with concurrent recordings of the spinal cord's input (peripheral nerve action potentials) and output (SEPs in brainstem and cortex). In two separate experiments, we first methodologically validate the approach (including replication and robustness analyses) and then assess its application in the context of a neuroscientific question (integrative processes along the neural hierarchy). Critically, we demonstrate the benefits of multi-channel recordings in terms of enhancing sensitivity via spatial filtering, which also allows for obtaining spinal cord SEPs at the single-trial level. We make use of this approach to demonstrate the feasibility of recording spinal cord SEPs in low-signal scenarios (single-digit stimulation) and — most importantly — to provide evidence for bottom-up signal integration already at the level of the spinal cord. Taken together, our approach of concurrent multi-channel recordings of evoked responses along the neural hierarchy allows for a comprehensive assessment of the functional architecture of somatosensory processing at a millisecond timescale.

show abstract

Les explorations neurophysiologiques dans les tumeurs médullaires

Obadia

Mauguı̀ere

2017

Neurochirurgie

View full text Add to dashboard Cite

Neural generators of tibial nerve P30 somatosensory evoked potential studied in patients with a focal lesion of the cervicomedullary junction

Cited by 14 publications

References 41 publications

Evidence for an abnormal cortical sensory processing in dystonia: Selective enhancement of lower limb P37-N50 somatosensory evoked potential

Evidence for an abnormal cortical sensory processing in dystonia: Selective enhancement of lower limb P37-N50 somatosensory evoked potential

A multi-channel electrophysiology approach to non-invasively and precisely record human spinal cord activity

Les explorations neurophysiologiques dans les tumeurs médullaires

Contact Info

Product

Resources

About