Neural input and neural control of the subcommissural organ

Jiménez, Antonio J.; Fernández-Llébrez, Pedro; Pérez-Fígares, J. M.

doi:10.1002/1097-0029(20010301)52:5<520::aid-jemt1037>3.0.co;2-6

Cited by 24 publications

(13 citation statements)

References 80 publications

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“…At variance with other non-neuronal cells, SCO cells are richly innervated (Bouchaud and Bosler 1986;Rodríguez et al 1992;Jiménez et al 2001) and are under the influence of various neurotransmitters Schöniger et al 2001Schöniger et al , 2002aSchöniger et al , 2002b. The serotonergic input to the SCO has been fully substantiated (Bouchaud and Bosler 1986;Rodríguez et al 1992;Jiménez et al 2001), and its inhibitory role on the secretion of RF-glycoproteins (Møllgard et al 1978;Bouchaud 1979;Léger et al 1983), in particular on the synthesis of SCO-spondin (H.G.…”

Section: Localization By Immunocytochemistrymentioning

confidence: 99%

“…The serotonergic input to the SCO has been fully substantiated (Bouchaud and Bosler 1986;Rodríguez et al 1992;Jiménez et al 2001), and its inhibitory role on the secretion of RF-glycoproteins (Møllgard et al 1978;Bouchaud 1979;Léger et al 1983), in particular on the synthesis of SCO-spondin (H.G. Richter, M. Tomé, C.R.…”

Section: Localization By Immunocytochemistrymentioning

confidence: 99%

“…Dopamine has been found to be present in the CSF of the sheep (Ruckebusch and Sutra 1984); the dopamine precursor L-DOPA is the most abundant monoamine in the rat CSF (Rodríguez et al 1999). Tyrosine-hydroxylase-immunoreactive fibers, most probably corresponding to dopamine fibers, have been observed to reach the secretory ependy- Balaban et al 1994;Jiménez et al 2001), suggesting the possibility that this brain gland may be under the influence of dopamine neurons.…”

Section: Introductionmentioning

confidence: 99%

“…The elucidation of the mechanisms controlling the secretory activity of the SCO may contribute to the further unfolding of the overall function of this brain gland. Although several neural systems are apparently involved in the control of the secretory activity of the SCO (Bouchaud and Bosler 1986;Jiménez et al 2001;Nürnberger and Schöniger 2001), the serotonergic input to the SCO originating in the raphe nuclei has been substantiated (Bouchaud and Bosler 1986;Rodríguez et al 1992;Jiménez et al 2001) and its role partially clarified. According to Møllgard et al (1978), Bouchaud (1979), andLéger et al (1983), serotonin plays an inhibitory control on the secretory activity of the SCO.…”

Section: Introductionmentioning

confidence: 99%

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The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors

Tomé¹,

Jiménez²,

Richter

et al. 2004

Cell Tissue Res

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Dopamine receptors have been found in certain populations of non-neuronal cells in the brain, viz., discrete areas of ciliated ependyma and the ependymal cells of the choroid plexus. We have studied the presence of both tyrosine-hydroxylase-immunoreactive nerve fibers and dopamine receptors in the subcommissural organ (SCO), an ependymal brain gland that is located in the roof of the third ventricle and that secretes, into the cerebrospinal fluid, glycoproteins that aggregate to form Reissner's fiber (RF). Antibodies against D2, D3, D4, and D5 dopamine receptors were used in immunoblots of bovine striatum, fresh SCO, and organ-cultured SCO, and in immunocytochemistry of the bovine, rat, and mouse SCO. Only a few tyrosine-hydroxylase fibers appeared to reach the SCO. However, virtually all the secretory ependymal and hypendymal cells of the SCO immunoreacted with antibodies against D2, D4, and D5 receptors, with the last-mentioned rendering the strongest reaction, especially at the ventricular cell pole of the secretory ependymocytes, suggesting that dopamine might reach the SCO via the cerebrospinal fluid. The antibodies against the four subtypes of receptors revealed corresponding bands in immunoblots of striatum and fresh SCO. Although the cultured SCO displayed dopamine receptors, dopamine had no apparent effect on the expression of the SCO-spondin gene/protein or on the release of RF-glycoproteins (SCO-spondin included) by SCO explants, suggesting that dopamine affects the function(s) of the SCO differently from the secretion of RF-glycoproteins.

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Section: Localization By Immunocytochemistrymentioning

confidence: 99%

Section: Localization By Immunocytochemistrymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors

Tomé¹,

Jiménez²,

Richter

et al. 2004

Cell Tissue Res

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“…In organ cultures, as in situ, the secretory cells remained joined by gap junctions and thus the organ works as a syncytium; so, relatively few signals can have important effects in the whole organ (Lehmann et al, 1993;González et al, 1999;Jimenez et al, 2001;Schöbitz et al, 2001;Schöniger et al, 2002b). At variance, in primary cultures, the secretory cells behave as individual entities and respond to stimuli according to their own receptor equipment.…”

Section: Primary Culture Of Bovine Sco Secretory Cells As a Model Sysmentioning

confidence: 99%

A sensitive method to analyse the effect of putative regulatory ligands on the release of glycoprotein from primary cultures of dispersed bovine subcommissural organ cells

Bermúdez‐Silva¹,

Pérez

Cifuentes

et al. 2010

Journal of Neuroscience Methods

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Endocannabinoid system in the adult rat circumventricular areas: An immunohistochemical study

Suárez¹,

Romero-Zerbo²,

Rivera³

et al. 2010

J of Comparative Neurology

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Endocannabinoids (ECs) are important neuromodulators involved in a plethora of physiological processes such as modulation of synaptic transmission, neuroprotection, immune function, and neurodevelopment, among others. However, still lacking is a detailed study on the presence of this system in the circumventricular areas, brain structures controlling the interaction between cerebrospinal fluid and brain parenchyma. The aim of this work was to provide the anatomical basis supporting a functional role of ECs in the activity of circumventricular areas. To this end, an immunohistochemical study of the EC system in rat brain was performed. Receptors and synthesizing and degrading enzymes for ECs were widely distributed in rat ependyma and subependyma, marginal glia, and circumventricular organs (CVOs) such as the choroid plexus, subfornical organ, subcommissural organ, median eminence, and area postrema. These zones constitute barrier systems between the brain parenchyma and the ventricular or subarachnoid cerebrospinal fluid (CSF) and between the extracellular hemal milieu of CVOs and the brain parenchyma or the CSF. By immunohistochemistry and real-time polymerase chain reaction we found DAGLalpha, DAGLbeta, NAPE-PLD, MAGL, and FAAH in the ependyma. These finding suggest that the ependyma can release and clear ECs from the ventricular CSF. Subependymal astrocytes and tanycytes displayed DAGLalpha immunoreactivity but parenchymal astrocytes did not express EC-synthesizing enzymes, thus establishing a sharp distinction between these two astrocyte populations. CB1 was located in fibers innervating discrete subventricular zones such as the neurogenic striatal subventricular zone and the fourth ventricle. CB1 fibers also innervated some CVOs.

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Neural input and neural control of the subcommissural organ

Cited by 24 publications

References 80 publications

The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors

The subcommissural organ expresses D2, D3, D4, and D5 dopamine receptors

A sensitive method to analyse the effect of putative regulatory ligands on the release of glycoprotein from primary cultures of dispersed bovine subcommissural organ cells

Endocannabinoid system in the adult rat circumventricular areas: An immunohistochemical study

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