Neural mechanisms of background and velocity effects in smooth pursuit eye movements

Schröder, Rebekka; Keidel, Kristof; Trautner, Peter; Radbruch, Alexander

doi:10.1002/hbm.26127

Cited by 6 publications

(5 citation statements)

References 93 publications

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“…This could also consider the wider brain network, such as the fronto-parietal network that controls eye-hand coordination 44 . Indeed, although there is some recent work on functional connectivity between visual, parietal and frontal areas during smooth pursuit 45 , 46 , the influence of higher cognitive control or the need to perform concurrent tasks remains to be determined. Tasks with competing demands are commonplace in normal daily settings, and are sensitive to changes in cognitive function associated with acute and chronic neurological conditions 47 .…”

Section: Discussionmentioning

confidence: 99%

Prefrontal cortex activity and functional organisation in dual-task ocular pursuit is affected by concurrent upper limb movement

Borot,

Ogden,

Bennett

2024

Sci Rep

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Tracking a moving object with the eyes seems like a simple task but involves areas of prefrontal cortex (PFC) associated with attention, working memory and prediction. Increasing the demand on these processes with secondary tasks can affect eye movements and/or perceptual judgments. This is particularly evident in chronic or acute neurological conditions such as Alzheimer’s disease or mild traumatic brain injury. Here, we combined near infrared spectroscopy and video-oculography to examine the effects of concurrent upper limb movement, which provides additional afference and efference that facilitates tracking of a moving object, in a novel dual-task pursuit protocol. We confirmed the expected effects on judgement accuracy in the primary and secondary tasks, as well as a reduction in eye velocity when the moving object was occluded. Although there was limited evidence of oculo-manual facilitation on behavioural measures, performing concurrent upper limb movement did result in lower activity in left medial PFC, as well as a change in PFC network organisation, which was shown by Graph analysis to be locally and globally more efficient. These findings extend upon previous work by showing how PFC is functionally organised to support eye-hand coordination when task demands more closely replicate daily activities.

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Section: Discussionmentioning

confidence: 99%

Prefrontal cortex activity and functional organisation in dual-task ocular pursuit is affected by concurrent upper limb movement

Borot,

Ogden,

Bennett

2024

Sci Rep

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“…Participants were once again informed about the fMRI procedures and criteria. Afterwards, they completed two different tasks in the fMRI scanner (the intertemporal choice task for this study as well as an eye movement task for a study published elsewhere [Schröder et al, 2023]). Afterwards, a structural T1 scan was obtained.…”

Section: Methodsmentioning

confidence: 99%

“…This included questions about the inclusion/exclusion criteria mentioned above as well as the MINI International Neuropsychiatric Interview (Sheehan et al, 1998;German translation by Ackenheil et al, 1999) to test for mental disorders and measurements of weight and height. Additionally, the UPPS-P Impulsive Behavior Scale (Lynam et al, 2006; Afterwards, they completed two different tasks in the fMRI scanner (the intertemporal choice task for this study as well as an eye movement task for a study published elsewhere [Schröder et al, 2023]).…”

Section: Study Proceduresmentioning

confidence: 99%

The date/delay effect in intertemporal choice: A combined fMRI and eye‐tracking study

Keidel,

Schröder,

Trautner

et al. 2024

Human Brain Mapping

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Temporal discounting, the tendency to devalue future rewards as a function of delay until receipt, is influenced by time framing. Specifically, discount rates are shallower when the time at which the reward is received is presented as a date (date condition; e.g., June 8, 2023) rather than in delay units (delay condition; e.g., 30 days), which is commonly referred to as the date/delay effect. However, the cognitive and neural mechanisms of this effect are not well understood. Here, we examined the date/delay effect by analysing combined fMRI and eye‐tracking data of N = 31 participants completing a temporal discounting task in both a delay and a date condition. The results confirmed the date/delay effect and revealed that the date condition led to higher fixation durations on time attributes and to higher activity in precuneus/PCC and angular gyrus, that is, areas previously associated with episodic thinking. Additionally, participants made more comparative eye movements in the date compared to the delay condition. A lower date/delay effect was associated with higher prefrontal activity in the date > delay contrast, suggesting that higher control or arithmetic operations may reduce the date/delay effect. Our findings are in line with hypotheses positing that the date condition is associated with differential time estimation and the use of more comparative as opposed to integrative choice strategies. Specifically, higher activity in memory‐related brain areas suggests that the date condition leads to higher perceived proximity of delayed rewards, while higher frontal activity (middle/superior frontal gyrus, posterior medial frontal cortex, cingulate) in participants with a lower date/delay effect suggests that the effect is particularly pronounced in participants avoiding complex arithmetic operations in the date condition.

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“…When presenting moving visual distractors, smooth pursuit eye movements typically follow the vector average of distractor and target motion (Lisberger & Ferrera, 1997;Spering, Gegenfurtner, & Kerzel, 2006). Similarly, tracking a target in front of a stationary textured background causes retinal motion in the opposite direction of smooth pursuit and results in decreased eye velocity (Keller & Khan, 1986, Kimmig, Miles, & Schwarz, 1992, Mormann & Thier, 1995Spering & Gegenfurtner, 2007;Kreyenmeier, Fooken, & Spering, 2017;Schröder, Keidel, Trautner, Radbruch, & Ettinger, 2022; for a review see Spering & Gegenfurtner, 2008). In our study, the visual distractor consisted of a stationary horizontally-oriented sinusoidal grating that does not cause any more retinal motion in the opposite direction of smooth pursuit than the frame of the computer monitor.…”

Section: Common Mechanism For Pursuit and Saccade Inhibition?mentioning

confidence: 99%

Smooth pursuit inhibition reveals audiovisual enhancement of fast movement control

Kreyenmeier,

Bhuiyan,

Gian

et al. 2024

Journal of Vision

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The sudden onset of a visual object or event elicits an inhibition of eye movements at latencies approaching the minimum delay of visuomotor conductance in the brain. Typically, information presented via multiple sensory modalities, such as sound and vision, evokes stronger and more robust responses than unisensory information. Whether and how multisensory information affects ultra-short latency oculomotor inhibition is unknown. In two experiments, we investigate smooth pursuit and saccadic inhibition in response to multisensory distractors. Observers tracked a horizontally moving dot and were interrupted by an unpredictable visual, auditory, or audiovisual distractor. Distractors elicited a transient inhibition of pursuit eye velocity and catch-up saccade rate within ∼100 ms of their onset. Audiovisual distractors evoked stronger oculomotor inhibition than visual-or auditory-only distractors, indicating multisensory response enhancement. Multisensory response enhancement magnitudes were equal to the linear sum of responses

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Neural mechanisms of background and velocity effects in smooth pursuit eye movements

Cited by 6 publications

References 93 publications

Prefrontal cortex activity and functional organisation in dual-task ocular pursuit is affected by concurrent upper limb movement

Prefrontal cortex activity and functional organisation in dual-task ocular pursuit is affected by concurrent upper limb movement

The date/delay effect in intertemporal choice: A combined fMRI and eye‐tracking study

Smooth pursuit inhibition reveals audiovisual enhancement of fast movement control

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